[1PS-03-06_2P-080] Knockout of Cdc7 or ASK (Dbf4) mice causes common and distinct phenotypes in a tissue-specific manner.

^○Tomohiro Iguchi¹, Karin Hori¹, Satoshi Yamazaki¹, Rie Ishii², Hiroyuki Sasanuma¹, Hisao Masai¹ (1.Dept. Basic Med. Sci., Genomic Dynamics Project, Tokyo Metropolitan Inst. Med. Sci., 2.Cent. For Basic Tech. Res., Lab. For Transgenic Tech., Tokyo Metropolitan Inst. Med. Sci.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 5:37 PM - 5:52 PM

[1PS-03-07] The CDC7 inhibitor-induced replication stress inflames the aneuploid cells to sensitize immune checkpoint inhibitors

^○Akihiro Ohashi (NCC, EPOC, Collab. Res. Dev.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 5:52 PM - 6:12 PM

[1PS-03-Conclusion] Conclusion

^○Shiotani Bunsho (National Cancer Center)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 6:12 PM - 6:15 PM

[1PS-04-01_2P-865] Single-cell transcriptomics for evaluating early clonal expansion in breast cancer

^○Jun Nakayama^1,2, Yusuke Yamamoto¹ (1.Lab. of Integr. Oncol., Natl. Cancer Ctr. Res. Inst., 2.Dept. of Oncogenesis Growth Regulation, Res. Inst., Osaka Intl. Cancer Inst.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 4:00 PM - 4:13 PM

[1PS-04-02] FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

^○Noriko Gotoh (Can. Res. Inst., Kanazawa Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 4:13 PM - 4:33 PM

[1PS-04-03] Targeting DHX9 triggers viral mimicry response and replication stress in Small Cell LungCancer

^○Takahiko Murayama, Israel Canadas (Fox Chase Cancer Center)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 4:33 PM - 4:48 PM

[1PS-04-04_2P-857] Down-regulation of tumor suppressor sST2 in hypoxic colorectal cancer cells and suppression of tumor growth and metastasis by its restoration

^○Miho Akimoto¹, Takao Susa¹, Noriyuki Okudaira¹, Nobuko Kosikawa², Harumi Hisaki¹, Masayoshi Iizuka^1,3, Keizo Takenaga², Mimi TamamoriAdachi¹ (1.Dept. of Biochem., Teikyo Univ. Sch. of Med., 2.Lab. Innov. Cancer Ther., Chiba Cancer Ctr. Res. Inst., 3.Med. Educ. Ctr., Teikyo Univ. Sch. of Med.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 4:48 PM - 5:01 PM

[1PS-04-05] Construction of an in vitro experimental model reproducing cancer-stromal cell interactions in colorectal cancer

^○Mie Naruse¹, Shigeki Sekine², Hiroe Nozaki³, Toshio Imai⁴, Hidetoshi Kassai¹ (1.Central. Anim. Div., Natl. Cancer Ctr. Res. Inst., 2.Dept. Clin. Path., Natl. Cancer Ctr. Res. Inst., 3.Mol. Toxico., Natl. Inst. Health Sci., 4.Central Inst. for Exp. Anim.)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 5:01 PM - 5:14 PM

[1PS-04-06_2P-872] Establishment of cholangiocarcinoma organoids and treatment targeting intratumoral neutrophils

^○Osamu Sugahara¹, Daisuke Koga³, Tsunaki Higa¹, Takeru Oka¹, Shigeaki Sugiyama¹, Reona Wada¹, Keiichi Nakayama^1,2 (1.Dept. of Mol. Cell. Biol., MIB, Univ. of Kyushu, 2.Adv. Res. Ins., TMDU, 3.AI Sys. Med., TMDU)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 5:24 PM - 5:40 PM

[1PS-04-07] Roles of EBAG9 in cancer

^○Satoshi Inoue^1,2, Kuniko Horie² (1.Tokyo Metropolitan Institute for Geriatrics and Gerontology, 2.Saitama Medical University)

The 46th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 6, 2023 5:27 PM - 5:51 PM