[1P-721] Evaluation of an FUS-linked ALS cellular model using the microfluidic cell culture system.

^○Asako Otomo^1,2, Keiko Nishijima¹, Yuta Murakami³, Mitsuru Ishikawa⁴, Hiroshi Kimura^2,3, Shinji Hadano^1,2 (1.Dept. of Physiol., Tokai Univ. Sch. Med., 2.MNTC., Tokai Univ., 3.Grad. Sch of Eng., Tokai Univ., 4.Dept. of Physiol. Keio Univ. Sch. Med.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-722] Investigation of the mechanism of aggregate formation and identification of aggregation factors to elucidate the pathological mechanism in neuronal intranuclear inclusion disease (NIID)

^○Keiichiro Asano (Dept. of Mol. Biol., Grad. Sch. of Med., Univ. of Yokohama City)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-723] DNA targeting therapy for CAG/CTG triplet repeat diseases through repeat-expanded allele-specific transcription inhibition

^○Kazuya Matsuo¹, Susumu Ikenoshita^1,2, Yasushi Yabuki^1,3, Hiroshi Sugiyama⁴, Norifumi Shioda^1,3 (1.Dept. Genomic Neurol., IMEG, Kumamoto Univ., 2.Dept. Neurol., Grad. Sch. Med. Sci., Kumamoto Univ., 3.Grad. Sch. Pharm. Sci., Kumamoto Univ., 4.Dept. Chem., Grad. Sch. Sci., Kyoto Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-724] EXPLORATION OF PATHOGENIC MOLECULES IN MOTOR NEURON DISEASE USING THE HUMAN IPSC-DERIVED NEUROMUSCULAR MODEL

^○Takuji Ito¹, Muhammad Irfanur Rashid¹, Kazunari Onodera^1,3, Rina Okada¹, Daisuke Shimojo^1,4, Satoshi Tanaka⁵, Masahisa Katsuno³, Gen Sobue⁶, Manabu Doyu², Hideyuki Okano⁴, Yohei Okada¹ (1.Department of Neural iPSC Research Institute for Medical Science of Aging, Aichi Medical University, 2.Department of Neurology, Aichi Medical University School of Medicine, 3.Department of Neurology, Nagoya University Graduate School of Medicine, 4.Department of Physiology, Keio University School of Medicine, 5.Department of Orthopedics, Nagoya University Graduate School of Medicine, 6.Aichi Medical University)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-725] Toward Elucidating the Mechanisms of Spinal Cord Injury-Induced Neurogenesis Decline in the Adult Hippocampus

^○Shu Kunoh, Yicheng Zhu, Shotaro Kai, Taito Matsuda, Kinichi Nakashima (Dept. of Stem Cell Biol. Med., Grad.Sch. of Med.,Univ. of Kyushu)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-726] Development of novel biomarkers for testing of psychiatric disorders

^○Masaki Fukuyama¹, Hiromasa Imaishi² (1.Dept. of Life Sci., Grad Sch. of Agri., Univ. of Kobe, 2.Biosig. Res. Cen., Univ. of Kobe)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-727] Validation of a method to control intracellular Tau aggregation by blue light irradiation

^○Yoshihiro Sakata¹, Shigeo Sakuragi⁴, Yoshiyuki Soeda³, Akihiko Takashima³, Hideaki Yoshimura², Hiroko Bannai⁴ (1.Dept. of Elec. Eng. Biosci., Grad. Sch. of Adv.Sci.Eng.,Waseda univ., 2.Dept. Chem., Grad. Sch. of Sci., Univ. of Tokyo, 3.Fac. of Sci., Gakusyuin univ., 4.Fac. of Sci. Eng., Waseda univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-728] Inhibition of microglial activation and protection to dopaminergic neurons by a novel COX-2 inhibitor

^○Hiromi Suzuki, Kenji Ono, Makoto Sawada (Dept. of BLS, RIEM, NAGOYA Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-729] Diversity in gene expression status and disease progression in patients with late-onset Alzheimer's disease

^○KOSEI HONDA, AKINORI AWAZU (Grad.Sch.Integrated Science for Life, Univ. Hiroshima)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[1P-730] Elucidation of mechanism of the aggregated tau clearance by photo-oxygenation

^○Hanako Nakagawa¹, takanobu suzuki¹, taka sawazaki^2,3, youhei sohma^2,3, motomu kanai², yukiko hori¹, taisuke tomita¹ (1.Lab. of Neuropathol. and Neurosci., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 2.Lab. of Synth. Org. Chem., Grad. Sch. of Pharm. Sci., Univ. of Tokyo, 3.Dept. of Med. Chem., Sch. of Pharm. Sci., Wakayama Medical Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan