[2P-726_2SP-09-04] The mechanism of neurodegeneration in phospholipid flippases ATP8A1/ATP8A2 double knock-out mice and the development of the therapeutic method

^○Shu Tokunaga¹, Yuta Umemura¹, Muneyuki Kawase¹, Tsuzumi Nakajima¹, Hisashi Oishi², Mitsuharu Hattori¹ (1.Dept. Biomed. Sci., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2.Dept. Comp. Exp. Med., Grad. Sch. Med. Sci., Nagoya City Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-727] Neat1 lncRNA is a key regulator of neuroinflammation in primary sensory neurons.

^○Motoyo Maruyama^1,2, Atsushi Sakai², Tsukasa Fukunaga^3,4, Yoshitaka Miyagawa⁵, Takashi Okada^5,6, Michiaki Hamada^7,8,9, Hidenori Suzuki² (1.Div. of Anim. Sci., Nippon Med. Sch, 2.Dept. of Pharmacol., Nippon Med. Sch., 3.Waseda Inst. for Adv. Study., Waseda Univ., 4.Dept. Comp. Sci., The Univ. of Tokyo, 5.Dept. Biochem. and Mol. Biol., Nippon Med. Sch., 6.The Inst. of Med. Sci., The Univ. of Tokyo, 7.Grad. Sch. of Adv. Sci. and Eng., Waseda Univ., 8.AIST-Waseda Univ. Comp. Bio Big-Data Open Innov. Lab. (CBBD-OIL), 9.Grad. Sch. of Med., Nippon Med. Sch.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-728_2SP-09-06] Effects of neuronal nuclear structural abnormalities and micronuclear propagation in aging

^○Chihiro Maeda¹, Takumi Taketomi², Fuminori Tsuruta³ (1.Grad. Sch. of LIfe and Env. Sci., Univ. of Tsukuba, 2.Ph.D. Program in Human Biology, University of Tsukuba, 3.Faculty of Life and Env. Sch., Univ. of Tsukuba)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-729] Analysis of extracellular long non-coding RNAs as a neuropathy marker using human iPS cell-derived primary sensory neurons

^○Atsushi Sakai¹, Takeshi Yamada², Motoyo Maruyama^1,3, Koji Ueda², Toshimitsu Miyasaka², Hiroshi Yoshida², Hidenori Suzuki¹ (1.Dept. of Pharmacol., Nippon Med. Sch., 2.Dept. of Gastrointestinal Hepato-Biliary-Pancreatic Surg., Nippon Med. Sch., 3.Div. of Lab. Anim. Sci., Nippon Med. Sch.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-730_2SP-10-01] Co-culture of Individually Differentiated Neurons and Astrocytes from iPSCs Elicited Alzheimer's Disease-like Phenotypes

^○Sopak Supakul¹, Rei Murakami¹, Chisato Oyama², Yuki Hatakeyama¹, Sumihiro Maeda¹, Hideyuki Okano¹ (1.Dept. of Physiol., Grad. Sch. of Med., Keio Univ., 2.ASE, Waseda Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-731_1PS-03-03] Causative actions of cell cycle re-entry-associated L1 retrotransposition for autonomous cell death in matured neurons.

^○Fumio Takahashi, Takashi Yamamura, Shinji Oki (Dept. of Immunol., Natl Inst Neurol. NCNP)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-732] Molecular mechanisms of synaptic dysfunction induced by amyloid-β

^○Minami Ryunosuke¹, YoungMi Lim², Tsuda Leo³ (1.Asahikawa Med. Univ., 2.NCGG, 3.Kankyo Eisei Yakuhin Co. Ltd)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-734] Analysis of oligodendrocyte lineage cell diversity in a mouse cerebral infarction model

^○Ryusei Abe, Mitsuhiro Awaya, Aurelien Kerever, Marika Aoki, Takahiro Tanaka, Eri ArikawaHirasawa (Research Institute for Diseases of Old Age, Juntendo Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-735] Mechanism of neurotoxic astroglial activation by mitochondrial reactive oxygen species

^○Masato Ogura, Junko Yamaki, Miwako Homma (Dept. of Biomol. Sci., Fukushima Med. Univ. Sch. of Med.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[2P-736] Establishment of two Gt(ROSA)26Sor-CAG-LF-AKT1 knock-in mouse lines (active form and wild-type form) induced by Cre and FLP recombinases.

^○Kiyo Sakagami^1,2, Riku Kurokawa¹, Hitoshi Miyachi³, Satsuki Kitano³, Hiromi Sano⁴, Kenta Kobayashi⁵, Atsushi Ogura^1,6 (1.Nagahama Inst. Bio-Sci. and Tech., Dept. Biol-Sci., 2.Ritsumeikan Univ., R-GIRO, 3.Inst. for Life and Med. Sci., Kyoto University, 4.Internat. Cent. for Brain Sci., Fujita Health University, 5.Section of Virus Vector Devel., National Insti. of Physiol. Sci., 6.Nagahama Inst. Bio-Sci. and Tech., Grad. School of Biol-Sci.)

The 46th Annual Meeting of the Molecular Biology Society of Japan