Symposium

[S69] Precise Chemical Control of Appropriate Biological Responses

Sun. Mar 31, 2024 3:30 PM - 5:30 PM [Room 502] Conference Center 502 (5F)

Organizer: Hiroyuki Miyachi (drug discovery initiative, Tokyo Univ.), Kazuo Nagasawa (Grad. Sch. Tec., Tokyo Noukou Univ.)

Conventionally, the synthesis of organic compounds aimed at analyzing and controlling biological functions, as well as creating pharmaceuticals, has traditionally focused on structural development of compounds using in-vivo ligands and natural products as starting points. Many results have been obtained. However, in today's post-genome era, there is a need for the creation of chemical and pharmacological tools that are more functional and highly active than ever before, and that exhibit appropriate effects and efficacy in vivo. We believe that the key is to accumulate and organize precise and multifaceted biological function information, and to come up with bold ideas and put them into practice based on this information.
In this symposium, we will propose a variety of highly functional chemical tools, pharmacological tools, and even drug discovery concepts based on our own logic, ideas, and concepts, and highlight the pioneering research that is being actively conducted on synthesis and evaluation. We will have a lecture by a person. I would like to think about the future creation of precision biological response modulators from each presentation.

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趣旨説明：宮地弘幸（東大院薬　創薬機構） (3:30 PM - 3:32 PM)

3:32 PM - 3:55 PM

[S69-1] Expanding the repertoire of pharmacological chaperones for lysosomal proteins

○Kenji Ohgane¹ (1. Grad. Sch. Adv. Sci., Ochanomizu Univ.)

3:55 PM - 4:18 PM

[S69-2] Development of helical template peptides and their application for DDS carrier.

○Takashi Misawa¹, Takahito Ito^1,2, Takuma Kato³, Nobumichi Ohoka¹, Takao Inoue¹, Mitsunobu Doi³, Yosuke Demizu^1,2 (1. Division of organic chemistry, National institute of health sciences, 2. Graduate of school of medical life science, Yokohama city university, 3. Faculty of pharmacy, Osaka medical and pharmaceutical university)

4:18 PM - 4:41 PM

[S69-3] Near-infrared light-activatable proximity histidine labeling

○Shinichi Sato¹, Taniyuki Furuyama² (1. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 2. Nanomaterials Research Institute, Kanazawa University)

4:41 PM - 5:05 PM

[S69-4] Anti-cancer drug development based on targeted protein degradation

○Mikihiko Naito¹ (1. Grad Sch Pharm Sci, Univ Tokyo)

5:05 PM - 5:29 PM

[S69-5] Precision Molecular Design of Nuclear Receptor Ligands

○Hiroyuki MiyachiHiroyuki¹ (1. Drug Discovery Initiative, Grad Sch Pharm Sci, Univ Tokyo)

まとめ：長澤和夫（農工大院工） (5:29 PM - 5:30 PM)

Session information