[3P-718_3SP-09-02] Whole-Brain Cellome-Wide Association Study (CWAS) reveals Microscale Neurodegenerative Trajectories in a 3D Cellular Landscape

^○Tomoki Mitani^1,2,3, Kosei Yamaura^1,3, Katsuhiko Matsumoto^3,4, Etsuo Susaki^5,3, Hiroki Ueda^1,3,4 (1.Dept. of Systems Biology Grad. Sch. Med., Osaka Univ., 2.Dept. of Neurology ,Grad. Sch. Med., Osaka Univ., 3.Laboratory for Synthetic Biology, RIKEN Ctr. for Biosystems Dynamics Res., 4.Dept. of Systems Pharmacology, Grad. Sch. Med., Univ. of Tokyo, 5.Dept. of Biochemistry and Systems. Biomedicine, Grad. Sch. Med., Juntendo Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-719] Molecular network analysis of multi-omics data.

^○Rie Taniguchi, Miki Shigetaka, Yoko Inoue, Nakako Iwasaki, Mieko Ohota, Kazuko Mashino, Shizuka Miyahara, Makoto Shigetaka (KM data.Inc)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-720] Analysis of the effect of amino acid D-isomerization on the process of tau fibrillation

^○Takuya Murata, Genta Ito, Naoko Tate (Facul. of Pharm. Sci., Teikyo Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-721] hnRNP L regulates cryptic splicing of UNC13A, the ALS/FTD risk gene, under TDP-43 depletion

^○Yuka Koike (Dept. of Mol. Neuro Sci., Univ. of Niigata)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-722] Mitochondrial dysfunction via calcium homeostasis disruption as as a cellular pathogenesis of Pelizaeus-Merzbacher Disease

^○Heng Li, Reiko Mishima, Yuichi Goto, Ken Inoue (Dept. of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-723] H. pylori infection increases immune related gene expression in the brain of a mouse model of Alzheimer's disease: involvement of H. pylori OMV-induced cytokine production.

^○AhMee Park^1,2, Seiichi Omura², Fumitaka Sato², Ikuo Tsunoda² (1.Dept. Arts & Sci., Facul. of Med., Kindai Univ., 2.Dept. Microbiol., Facul. of Med., Kindai Univ.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-724] Identification of mitigating factors of H. sapiens Aβ cytotoxicity in the embryonic development of C. elegans

^○Mao Onishi¹, Mitsuki Ohara¹, King Law¹, Yukihiko Kubota², Masahiro Ito^2,1 (1.Dept. of Life Sci., Grad. Sch. of Life Sci., Univ. of Ritsumeikan, 2.Dept. of Bioinfo., Col. of Life Sci., Univ. of Ritsumeikan)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-725_3AS-17-04] Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson’s disease caused by CHCHD2 gene mutations

^○Satoru Torii¹, Satoko Arakawa², Shigeto Sato³, Keiichi Ishikawa^3,4, Daisuke Taniguchi³, Hajime Sakurai⁵, Shinya Honda¹, Yuuichi Hiraoka^6,7, Masaya Ono⁸, Wado Akamatsu⁴, Nobutaka Hattori³, Shigeomi Shimizu¹ (1.Dept. of Pathol. Cell Biol., Med. Res. Inst., Tokyo Med. Dent. Univ., 2.Res. Core Cent., Tokyo Med. Dent. Univ., 3.Dept. of Neurol., Sch. of Med., Juntendo Univ., 4.Cent. for Gen. Reg. Med., Juntendo Univ., 5.Dept. of Mol. Biochem., Grad. Sch. of Life Sci., Univ. of Hyogo, 6.Lab. of Mol. Neuro., Med. Res. Inst., Tokyo Med. Dent. Univ., 7.Lab. of Gen. Edit. for Biomed. Res., Med. Res. Inst., Tokyo Med. Dent. Univ., 8.Dept. of Clin. Proteo., Nat. Can. Cent. Res. Inst.)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-726] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs

^○Zohora Khatun¹, Kazunari Onodera¹, Shinichi Yamaguchi¹, Rina Okada¹, Takuji Ito¹, Muhammad Irfanur Rashid¹, Haruhisa Inoue², Masashi Aoki³, Hideyuki Okano⁴, Manabu Doyu⁵, Yohei Okada¹ (1.1.Dept. of Neural iPSC Research,Institute for Medical Science of Aging, Aichi Medical University, 2.Center for iPS Cell Research and Application (CiRA), Kyoto University, 3.Department of Neurology, Tohoku University Graduate School of Medicine, 4.Department of Physiology, Keio University School of Medicine, 5.Department of Neurology, Aichi Medical University School of Medicine)

The 46th Annual Meeting of the Molecular Biology Society of Japan

[3P-727] Neuropeptide regulation of the prefrontal cortex development related to autism spectrum disorder

^○Yoki Tatsumi, Kaori Emoto, Daichi Kawaguchi, Yukiko Gotoh (Grad. Sch. of Ps.)

The 46th Annual Meeting of the Molecular Biology Society of Japan