[A22-2pm] 16. Natural Products Chemistry, Chemical Biology

[A22-2pm-12] Chemo-enzymatic synthesis of Saframycin-type scaffold and modification of DNA alkylating ability by changing substituent on N12

^○Hirohito Okuno¹, Ryo Tanifuji², Taro Shiraishi², Ryutaro Asano¹, Tomohisa Kuzuyama², Hiroki Oguri² (1. Tokyo University of Agriculture and Technology, 2. The University of Tokyo)

[Lang.] Japanese

Keywords:tetrahydroisoquinoline alkaloids, chemo-enzymatic synthesis, DNA alkylation, substituent effect, natural products