[A22-4pm] 16. Natural Products Chemistry, Chemical Biology

[A22-4pm-04] Synthesis of new saxitoxin derivatives bearing substituents at C11 and evaluation their voltage-gated sodium channel inhibitory activity

^○Yuka Takayanagi¹, Minami Hoshi¹, Kanna Adachi¹, Hayate Ishizuka¹, Osamu Chiba², Tomoshi Yamada², Takatsugu Hirokawa^3,4, Keiichi Konoki², Mari Yotsu Yamashita², Kazuo Nagasawa¹ (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2. Graduate School of Agricultural science, Tohoku University, 3. Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, 4. Division of Biomedical Science, University of Tsukuba)

[Lang.] Japanese

Keywords:voltage-gated sodium channel, saxitoxin, zetekitoxinAB, guanidine alkaloid