[3S-Bm] Homeostasis in Living Organisms and Its Dysregulation: Unraveling Life Processes and Diseases through Biological Signals

[3B05] Molecular mechanism of immunosuppressive tumor microenvironment formation by the ARF6-AMAP1 pathway in malignant pancreatic cancer

*Ari Hashimoto¹, Haruka Handa¹, Daisuke Okuzaki², Tsukasa Oikawa¹, Soichiro Hata¹, Yoshizuki Fumoto¹, Akio Tsutaho³, Yoshihiro Nishikawa⁴, Yuzo Kodama^4,5, Satoshi Hirano³, Shigeru Hashimoto^1,6, Hisataka Sabe^1,6 (1. Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, 2. Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, 3. Department of Gastroenterological Surgery II, Graduate School of Medicine, Hokkaido University, 4. Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 5. Department of Gastroenterology, Kobe University Graduate School of Medicine, 6. Institute for Genetic Medicine, Hokkaido University)

Keywords:ARF6, AMAP1, tumor microenvironment, immune evasion, pancreatic cancer