Symposium

[S11] Innovative Protein Research by Powerful Chemistry

Fri. Mar 29, 2024 1:15 PM - 3:15 PM [Room 301] Conference Center 301 (3F)

Organizer: Katsumi Matsuzaki (Grad. Sch. Pharm. Sci., Kyoto Univ.), Akira Otaka (Grad. Sch. Pharm. Sci., Tokushima Univ.)

Elucidation of the structures and functions of proteins is important not only for understanding biological phenomena but also for drug discovery research. Essential technologies for protein research involve mass production of target proteins by recombinant expression or chemical synthesis and their site-specific chemical modification. In addition, in the case of membrane proteins, their solubilization and stabilization are key techniques. A method for incorporating in vitro-modified membrane proteins back into living cells would be a powerful approach for their in-cell analysis.
In this symposium, cutting-edge chemical methods for protein research will be presented and discussed, including the low-cost and efficient protein purification systems using oligosaccharides (by Kato), the peptide modification methods for the generation of artificial proteins (by Otaka), the chemical synthesis of difficult membrane proteins (by Hojo), the delivery of membrane proteins to cell membranes utilizing nanosiscs (by Ikeda), and the development of novel detergents enabling the facile structural and functional analysis of membrane proteins (by Matsuzaki).

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はじめに：松崎勝巳（京大院薬） (1:15 PM - 1:20 PM)

1:20 PM - 1:42 PM

[S11-1] Stable and minimum-size solubilization of membrane proteins with cocktails of phospholipid analogs

○Katsumi Matsuzaki¹, Mai Takagi¹, Ayami Hata¹, Ayana Nagatani¹, Azusa Yokoyama¹, Koichi Hayashida¹, Haruka Hoshi¹, Daisuke Yamasaki¹, Tsuyoshi Oyama¹, Kenichi Kawano¹, Yusuke Kuroda¹, Yousuke Yamaoka², Masaru Hoshino¹, Yoshiaki Yano³, Kiyosei Takasu¹ (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. Sch. Pharm., Hyogo Univ. Med. Sci., 3. Sch. Pharm. Pharm. Sci., Mukogawa Women’s Univ.)

1:42 PM - 2:04 PM

[S11-2] Synthetic strategy for membrane protein and its application

○Hironobu Hojo¹ (1. Inst. Protein Res., Osaka Univ.)

2:04 PM - 2:26 PM

[S11-3] Development of lipid-peptide nanoparticles for membrane protein delivery

○Keisuke Ikeda¹, Kanako Ikadai¹, Chiharu Anada¹, Hiroyuki Nakao¹, Minoru Nakano¹ (1. Fac. Pharm. Sci., Univ. Toyama)

2:26 PM - 2:48 PM

[S11-4] Oligosaccharide-based protein purification systems for enzyme discovery with novel catalytic activity

○Shunsuke Kato¹ (1. Grad. Sch. Eng., Osaka Univ.)

2:48 PM - 3:10 PM

[S11-5] Development of residue-selective modification reactions

○Akira Otaka¹ (1. Grad. Sch. Pharm. Sci., Tokushima Univ.)

まとめ (3:10 PM - 3:15 PM)

Session information