[S14] Novel challenges in academic drug discovery to fight cancer disease

Fri. Mar 29, 2024 1:15 PM - 3:15 PM [Room 311] Conference Center 311+312 (3F)

Organizer: Yasuyuki Nagumo (Div. Cancer Pathophysiol., NCCRI.), Kanako Miyano (Dept. Pain Cont. Res., The Jikei Univ. Sch. Med.)

Nowadays, since the number of novel drugs created by pharmaceutical companies decreases, there is a need to activate drug discovery through academic basic research. In this sense, Japanese government has been promoting drug discovery in academia. Since then, candidate compounds in academia have increased significantly, with particularly great results in the cancer field. However, despite the facts that oncology drug discovery is an unmet medical need and a priority area for pharmaceutical companies, out-licensing from academia to companies has been halted or stagnated from the viewpoint of efficacy and other factors. On the other hand, academia has begun to develop modalities for drug species (drug discovery modalities) as peptides, nucleic acids, and antibodies, although small molecule drug still accounts for more than half of the total share of drug discovery seeds. In this symposium, we will introduce new animal models, drug discovery modalities, and drug discovery seeds, with the hope of revitalizing novel academic drug discovery to fight cancer.

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挨拶・趣旨説明：南雲康行（国立がん研セ） (1:15 PM - 1:16 PM)

1:16 PM - 1:45 PM

[S14-1] Drug development for new anticancer agents using Japanese cancer patient-derived xenograft (PDX) models

○Akinobu Hamada¹ (1. National Cancer Center Research Institutes, Division of Molecular Pharmacology)

1:45 PM - 2:16 PM

[S14-2] Evolution and prospects of chemical modalities

○Yosuke Demizu¹ (1. NIHS)

2:16 PM - 2:44 PM

[S14-3] The molecular basis for targeted protein degradation

○Fumiaki Ohtake¹, Yoshino Akizuki¹, Yuki Mori¹ (1. Hoshi University)

2:44 PM - 3:14 PM

[S14-4] Current status and future prospects of academia drug discovery targeting epigenome abnormality

○Naoko Hattori¹, Yoshimi Yasukawa¹, Toshikazu Ushijima¹ (1. Inst. Adv. Life Sci., Hoshi Univ.)

まとめ：宮野加奈子（東京慈恵会医大） (3:14 PM - 3:15 PM)