[29-413-pm] Drug design 2

Fri. Mar 29, 2024 2:15 PM - 3:15 PM [Room 413] Conference Center 413 (4F)

Chair: Fujii Shinya, Satoshi Obika

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2:15 PM - 2:27 PM

[29-413-pm06S] Optimization of the 4'-thiomodification patterns on siRNA for effective anti-SARS-CoV-2 activities

○Yuhei Nogi¹, Noriko Saito Tarashima¹, Takaaki Koma², Jun Tsukimoto¹, Masako Nomaguchi², Noriaki Minakawa¹ (1. Graduate School of Pharmaceutical Science, Tokushima University, 2. Graduate School of Medicine, Tokushima University)

2:27 PM - 2:39 PM

[29-413-pm07S] Preparation of a chemically modified mRNA using 4'-thio-NTP analogs

○Chihiro Kuroda¹, Yuta Kashiwabara¹, Jun Tsukimoto¹, Noriko Saito Tarashima¹, Noriaki Minakawa¹ (1. Grad. Sch. Pharm. Sci., Tokushima Univ.)

2:39 PM - 2:51 PM

[29-413-pm08S] 3-Deazaguanosine showed anti SARS-CoV-2 activities via unexpected inhibition mechanism

○Keigo Yoshida¹, Naoto Hinotani¹, Moka Ogasa¹, Noriko Saito Tarashima¹, Takaaki Koma², Masako Nomaguchi², Noriaki Minakawa¹ (1. Graduate School of Pharmaceutical Science, Tokushima University, 2. Graduate School of Medicine, Tokushima University)

2:51 PM - 3:03 PM

[29-413-pm09S] Evaluation of RNAi activity of siRNA in Gryllus bimaculatus.

○Taketo Inoue¹, Noriko Saito Tarashima¹, Shintaro Inoue², Sumihare Noji², Taro Mito², Noriaki Minakawa¹ (1. Grad. School of Pharm. Sci., Tokushima Univ., 2. BIRC, Tokushima Univ.)

3:03 PM - 3:15 PM

[29-413-pm10S] Inducing the photo-responsible aggregation of the antibody-oligonucleotide conjugate via G-quadruplex formation.

○Mizuki Oba¹, Akiho Murai¹, Noriko Saito Tarashima¹, Jun Tsukimoto¹, Noriaki Minakawa¹ (1. Grad. Sch. Pharm. Sci., Tokushima Univ.)

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