[29P-am253] Effects of the formulation containing Bezoar Bovis and Ginseng Radix on heat shock proteins expression.

○Tomoe Tsubonoya¹, Eiji Inoue¹, Yasuharu Shimizu¹ (1. Tokyo Res. Ctr., Kyushin Pharm. Co., Ltd.)

[29P-am254] Effects of a combination crude drug product containing antler velvet and red ginseng on reproductive and courtship behavior in aged drosophila

○Eiji Inoue^1,2, Takahiro Suzuki^2,3,4, Yasuharu Shimizu¹, Yoshikazu Iwaki⁵, Haruhisa Kawasaki², Norio Ishida^2,6 (1. Tokyo Res. Ctr., Kyushin Pharm. Co., Ltd., 2. Institute for Chronobiology, Foundation for Advancement of International Science, 3. Graduate School of Agricultural and Life Sciences, Tokyo Univ., 4. SHIGRAY Inc, 5. Taise Co., Ltd., 6. Faculty of Nutrition, Tokyo Kasei Univ.)

[29P-am255S] Evaluation of the immunomodulating properties of cyanobacteria RNA for the application in vaccine adjuvants

○Otoya Aoyama¹, Akiko Inujima², Keiichi Koizumi³ (1. Pharm. Sci., TOYAMA Univ., 2. Research Center for Pre-Disease Science, Toyama Univ., 3. Inst. Nat. Med., Toyama Univ.)

[29P-am256S] Immune activity of nanoparticles prepared from Chlorella water decoction

○Aki Hiraishi¹, Otoya Aoyama², Akiko Inujima³, Shota Esaki⁴, Naoto Noguchi⁴, Toshihiro Kanno⁴, Keiichi Koizumi⁵ (1. Grad. Sch. of Med. and Pharm. Sci., Toyama Univ., 2. Pharm. Sci., Toyama Univ., 3. Research Center for Pre-Disease Science, Toyama Univ., 4. R&D, Chlorella Ind., 5. Inst. Nat. Med., Toyama Univ.)

[29P-am257] Exploration and effect analysis of activator of antioxidant stress response transcription factor Nrf2

○Yasuhiko Izumi¹, Norihiko Takeda¹, Kouya Yamaki¹, Toshiaki Kume², Masafumi Ueda¹, Yutaka Koyama¹ (1. Kobe Pharm Univ., 2. Grad. Sch. Med. & Pharm. Sci., Univ. of Toyama)

[29P-am258] Study of the inhibitory effect of FAD041 on H₂O₂-induced necrosis-like death in Neuro-2a cells

○Bien Gen¹, Kouichi Shikama¹, Haruka Shimasaki¹, Jun Takayama¹, Hirokazu Matsuzaki¹, Bo Yuan¹, Takeshi Sakamoto¹, Mari Okazaki¹ (1. Fac. Pharm. Sci., Josai Univ.)

[29P-am259S] Mechanisms by which cigarette smoke extracts derived from heated tobacco products injured brain endothelial cells

○Hisataka Aridome¹, Fuyuko Takata¹, Takuro Iwao¹, Tanaka Yasuyoshi¹, Miki Yokoya¹, Miho Yasunaga¹, Junko Mizoguchi¹, Takahiro Horinouchi², Shinya Dohgu¹ (1. Fac.Pharm.Sci.,Fukuoka Univ., 2. Grad.Sch.Med.,Hokkaido Univ.)

[29P-am260] Cigarette smoke extracts derived from heated tobacco products altered mRNA expression in brain endothelial cells and human iPSC-derived brain organoids.

○Shinya Dohgu¹, Yasuyoshi Tanaka¹, Satomi Tamura¹, Hisataka Aridome¹, Fuyuko Takata¹, Takuro Iwao¹, Miho Yasunaga¹, Miki Yokoya¹, Junko Mizoguchi¹, Takahiro Horinouchi² (1. Fac. Pharmaceut. Sci., Fukuoka Univ., 2. Grad.Sch.Med., Hokkaido Univ.)

[29P-am261S] Development of analysis system for presented peptides on HLA-A*11:01, an allele associated with sulfonamide-induced severe cutaneous adverse reactions

○Aoi Ito^1,2, Ryosuke Nakamura^1,2, Noriaki Arakawa², Yuya Hashimoto², Yuya Fukui², Ruri Hanajiri², Yoshiro Saito^1,2 (1. Grad. Sch. Med., Dent., and Pharm. Sci., Okayama Univ., 2. Natl. Inst. Health Sci.)

[29P-am262] Pharmacogenomic biomarkers for chemotherapy responsiveness
identified by integrated transcriptomic analyses

○Varalee Yodsurang¹, Wathunya Hawhan¹, Krittin Pitinanon¹, Chotiphuk Kusalasaiyanon¹, Pasrawin Taechawattananant² (1. Dept. Pharmaco. and Physio., Fac. Pharm. Sci., Chulalongkorn Univ, 2. Dept. Biochem. and Micro., Fac. Pharm. Sci., Chulalongkorn Univ)

[29P-am263] The epidermal growth factor receptor inhibitor epertinib reverses P-glycoprotein-mediated multidrug resistance in cancer cell lines

Yen-Ching Li¹, Bing-Huan Lin¹, Megumi Murakami², Suresh V Ambudkar², ○Chung-Pu Wu^1,3,4,5 (1. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan, 2. Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA., 3. Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., 4. Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan., 5. Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.)

[29P-am264] Expression analysis of transporter gene in the brain of PPE-induced pulmonary emphysema mouse.

○Junichi Matsumoto¹, Shinya Dohgu¹, Kentaro Aono¹, Shinsuke Nakagawa¹, Koshun Inada¹, Atsushi Yamauchi¹ (1. Pharm. Sci., Fukuoka Univ.)

[29P-am265] The colony-stimulating factor 1 receptor inhibitor edicotinib improves the efficacy of cytotoxic drugs in ABCG2-overexpressing multidrug-resistant cancer cells

○Yen Ching Li¹, Yun Chieh Lee¹, Chung Pu Wu^1,2,3,4 (1. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., 2. Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., 3. Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan., 4. Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.)

[29P-am266S] Functional analyses of CLC-3 chloride channels in human hepatic stellate LX-2 cells

○Rena Mori¹, Rubii Kondo¹, Naoki Kawata¹, Yoshiaki Suzuki¹, Hisao Yamamura¹ (1. Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.)

[29P-am267] Role of P2X4-mediated Ca²⁺ influx in regulating osteoblast differentiation

○Hiroaki Kito¹, Takusei Ryu¹, Rina Yamaguchi¹, Junko Kajikuri¹, Susumu Ohya¹ (1. Grad. Sch. Med. Sci., Nagoya City Univ. )

[29P-am268S] Elucidation of inhibitory mechanism on cancer cell proliferation by butyric acid focusing on MCT transporters

○Marina Takahashi¹, Mone Yasukawa¹, So Masaki¹, Noriko Takahashi^2,3, Kenji Suzuki¹ (1. Ritsumeikan Univ., 2. Res. Inst. Prod. Dev., 3. Hoshi Univ.)

[29P-am269] The contribution of OATP2A1 to the disposition of prostaglandin in liver

○Hiroaki Shimada¹, Yuske Yabuuchi¹, Atsushi Kawase¹ (1. Dept. Pharm., Kindai Univ.)

[29P-am270S] The expression levels of Histamine H1 receptor define sensitivity to loratadine.

○Kaori Ueki¹, Junichiro Kawasaki¹, Keisei Yoshimatsu¹, Rei Matsumoto¹, Keijo Fukushima¹, Hiromichi Fujino¹ (1. Grad. Sch. Pharm. Sci., Tokushima Univ.)

[29P-am271S] Exploring the factors interacting with the intracellular loop 3 of the EP4 receptor

○Akiko Higashiyama¹, Akito Ohnishi¹, Syunya Yanagawa¹, Naofumi Seira², John W Regan³, Kento Ohkawachi¹, Masaya Denda¹, Keijo Fukushima¹, Kohei Nishino⁴, Akira Ohtaka¹, Hidetaka Kosako⁴, Hiromichi Fujino¹ (1. Grad. Sch. Pharm. Sci., Tokushima Univ., 2. Grad. Sch. Phar. Sci., Chiba Univ., 3. Coll. of Pharm., The Univ. of Arizona, 4. Inst. of Adv. Med. Sci., Tokushima Univ.)

[29P-am272S] Inhibitor of mitochondrial NCLX attenuates vasoconstriction and smooth muscle cell migration

○Nana Kunimi¹, Wakana Tani¹, Takuya Matsubara¹, Takayuki Nemoto², Tomo Kita², Takahiro Iwamoto², Satomi Kita^1,2 (1. Dept. Pharmacol., Facul. Pharmaceu. Sci., Tokushima Bunri Univ., 2. Dept. Pharmacol., Facul. Med., Fukuoka Univ. )

[29P-am273] Investigating the expression of different G protein-coupled receptors co-transfected in cultured cells

○Hinako Suga^1,2, Yuji Kamikubo¹, Hakushun Sakairi¹, Takashi Sakurai¹ (1. Grad. Sch. Med., Juntendo Univ., 2. Sch. Health Sci. Odawara, Intl. Univ. Health Welfare)

[29P-am274] Proliferative effects of thyroid hormones on primary cultured of adult rat hepatic parenchymal cells

○hajime moteki¹, Miho Akimoto¹, Satori Inai¹, Masahiko Ogihara¹, Mitsutoshi Kimura¹ (1. Josai Univ.)

[29P-am275] Proliferative effects of erythropoietin in primary cultures of adult rat hepatocytes.

○Yuka Kano¹, Rina Ueki¹, Harua Nonaka¹, Hikaru Ohno¹, Hajime Moteki¹, Masahiko Ogihara¹, Mitsutoshi Kimura¹ (1. Josai Univ.)

[29P-am276S] Activation of EGFR-ERK signaling by 1,2-naphthoquinone

○Yuexuan Pan¹, Atsushi Morimoto¹, Sho Kubota¹, Nobumasa Takasugi¹, Yoshito Kumagai², Takashi Uehara¹ (1. Grad. Sch. Med. Dent. & Pharm. Sci., 2. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[29P-am277S] Elucidation of the mechanism of chlorpromazine-induced obesity -possible involvement of leptin resistance-.

○Kyosuke Kotani¹, Tadashi Nakagawa^1,2, Toru Hosoi¹ (1. Fac. Pharm. Sci., Sanyo-Onoda City Univ., 2. Grad. Sch. Med., Tohoku Univ.)

[29P-am278S] Relationship between HDAC and leptin signaling -elucidation of the intracellular mechanisms of anti-obesity factor-

○Nanako Matsuo¹, Tadashi Nakagawa^1,2, Toru Hosoi¹ (1. Fac. Pharm. Sci., Sanyo-Onoda City Univ., 2. Grad. Sch. Med., Tohoku Univ.)

[29P-am279S] Study of morphological and pharmacological evaluation for lactoferrin on PC12 cells

○Nana Ogawa¹, Daichi Nagashima^1,2, Noa Mizukami³, Megumi Ohno⁴, Nobuo Izumo^1,2 (1. Yokohama University of Pharmacy, 2. General Health Medical Research Center,Yokohama University of Pharmacy , 3. Tokyo Medical University , 4. NRL Pharma,Inc.)

[29P-am280S] Effects of raloxifene on LPS-induced bone density reduction model mice and involvement of macrophages

○Momoko Shimosato¹, Daichi Nagashima^1,2, Kai Suzuki¹, Nobuo Izumo^1,2 (1. Laboratory of Pharmacotherapy,Yokohama University of Pharmacy, 2. General Health Medical Research Center,Yokohama University of Pharmacy)

[29P-am281S] Plasmalogen decreases BACE1 protein expression

○Miki Yasuda¹, Chinatsu Nii¹, Ryo Sugishita¹, Keijo Fukushima¹, Koki Yuasa², Satoshi Kotoura², Hiromichi Fujino¹ (1. Grad. Sch. Pharm. Sci., Tokushima Univ., 2. Cent. Res. Inst., Marudai Food Co., Ltd)

[29P-am282] Effect of growth hormone receptor deficiency on androgen-associated gene expression of drug metabolizing enzymes and drug transporters in the pig liver

○Misaki Kojima^1,2, Daiichiro Fuchimoto³, Shiro Yamashita⁴, Akira Onishi⁵, Masakuni Degawa⁶, Kiyomitsu Nemoto² (1. Inst. Livestock and Grassland Sci., Natl. Agric. Food Res. Org. (NARO), 2. Fac. Pharm. Sci., Toho Univ., 3. Inst. Agrobiol. Sci., Natl. Agric. Food Res. Org. (NARO), 4. Cent. Res. Inst. Feed and Livestock, Zen-noh, 5. Col. Biores. Sci., Nihon Univ., 6. Sch. Pharm. Sci., Univ. Shizuoka)

[29P-am283] Modeled hepatic and plasma exposures of fluvastatin prescribed alone in subjects with cytochrome P450 2C93* likely associated with reported adverse drug events

Koichiro Adachi¹, Katsuhiro Ohyama², Yoichi Tanaka³, Norie Murayama¹, Makiko Shimizu¹, Yoshiro Saito³, ○Hiroshi Yamazaki¹ (1. Showa Pharma Univ, 2. Tokyo Univ Pharm and Life Sci, 3. NIHS)

[29P-am284] Modeled hepatic exposures of omeprazole prescribed alone in subjects with auto-inducible cytochrome P450 2C19 poor ecpressors likely associated with reported adverse drug events

○Norie Murayama¹, Shotaro Uehara^1,2, Katsuhiro Ohyama³, Koichro Adachi¹, Yoichi Tanaka⁴, Makiko Shimizu¹, Yoshirou Saito⁴, Hiroshi Yamazaki¹ (1. Showa Pharm. Univ., 2. CIEA, 3. Tokyo Pharm. Univ., 4. NIHS)

[29P-am285S] Different regulation of cytochrome P450 3a in liver and small intestine by cholesterol and cholic acid feeding in mice

○Chisato Shinagawa¹, Genki Minegishi¹, Yuichi Yamazaki², Satoru Kakizaki³, Atsushi Miyajima¹, Kaoru Kobayashi¹ (1. Meiji Pharmaceutical University, 2. Gunma University, 3. Takasaki General Medical Center)

[29P-am286] Functional analysis of rare but impaired flavin-containing monooxygenase 3 variants from updated database in Tohoku Medical Megabank Organization

○Makiko Shimizu¹, Eiji Hishinuma^2,3, Miaki Makiguchi¹, Sakae Saito^2,3, Masahiro Hiratsuka^2,3,4, Hiroshi Yamazaki¹ (1. Showa Pharma Univ, 2. INGEM, Tohoku Univ, 3. ToMMo, Tohoku Univ, 4. Grad Sch Pharm Sci, Tohoku Univ)

[29P-am287] Role of CYP2E1 in isoniazid-induced idiosyncratic liver injury

○Yasuhiro Masubuchi¹, Kyohei Miyauchi¹ (1. Fac. Pharm. Sci., Chiba Inst. Sci.)

[29P-am288S] Expression sites of thyroid hormone-metabolizing enzymes and pharmacological considerations

○Mei Yokoyama¹, Mana Mitsutani¹, Midori Matsushita¹, Aoi Morita¹, Hiromi Hano¹, Asuka Hamamoto¹, Tomomi Fujikawa¹, Kumi Futawaka¹, Ichirou Yamauchi², Tetsuya Tagami³, Kenji Moriyama^1,3 (1. Graduate School Pharmaceutical Sciences,Mukogawa Women's University., 2. Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, 3. National Hospital Organization Kyoto Medical Center)

[29P-am289S] Evaluation of non-transcriptional drug-metabolizing enzyme induction using the human hepatocyte cell line HepaRG.

○Yuto Fujita¹, Takahito Miyake¹, Masao Doi¹ (1. Grad. Sch. Pharm. Sci., Kyoto Univ.)

[29P-am290S] Analysis of functional interaction between peripheral µ-opioid receptors and immune checkpoint receptors under the tumor-bearing condition

○Natsumi Iwakiri¹, Yusuke Hamada^1,2, Satomi Ushiki^1,2, Yukari Suda^1,2, Takayasu Yamauchi¹, Naoko Kuzumaki^1,2, Minoru Narita^1,2 (1. Hoshi Univ., 2. Natl. Cancer Ctr. Res. Inst.)

[29P-am291] A novel MRGPRA3 agonist discovered by chemical screening induces non-histaminergic itching

○Tomohiro Yamashita¹, Mayu Ito¹, Yuka Kawanami¹, Keisuke Koga¹, Kensho Kanehisa¹, Shiori Fujii¹, Makoto Tsuda¹ (1. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[29P-am292S] Effect of cisplatin on changing in the gene expression of collagen and elastin in dermal fibroblast

○Miho Kiyama¹, Yu Miyauchi¹, Fumiaki Sato¹, Risako Kon¹, Nobutomo Ikarashi¹, Yoshihiko Chiba¹, Tomoo Hosoe¹, Hiroyasu Sakai¹ (1. Hoshi Univ.)

[29P-am293S] Downregulation of Fndc5/Irisin in skeletal muscle during cisplatin-induced muscle atrophy

○Takayuki Ogiwara¹, Yu Miyauchi¹, Shinki Soga¹, Hayato Nanri¹, Miho Kiyama¹, Ken Sato¹, Risako Kon¹, Nobutomo Ikarashi¹, Yoshihiko Chiba¹, Tomoo Hosoe¹, Hiroyasu Sakai¹ (1. Hoshi Univ.)

[29P-am294S] Investigation of E3 ubiquitin ligase with altered gene expression during cisplatin-induced muscle atrophy

○Yuan Someya¹, Yuya Chigasa¹, Shinki Soga¹, Hayato Nanri¹, Miho Kiyama¹, Takayuki Ogiwara¹, Yu Miyauchi¹, Yoshihiko Chiba¹, Risako Kon¹, Nobutomo Ikarashi¹, Tomoo Hosoe¹, Hiroyasu Sakai¹ (1. Hoshi Univ.)

[29P-am295] Functional Analysis of the Nucleolar Stress Response in Treatment Sensitivity of Pediatric Tumors

○KOHICHI KAWAHARA¹, SHUNSUKE NAKAGAWA¹, KEITA YAMASHITA², YUKICHIKA YASUKI², KAZUNARI ARIMA², YASUHIRO OKAMOTO¹ (1. Grad. Sch. Med. Dent. Sci. Kagoshima Univ., 2. Grad. Sch. Sci. and Eng. Kagoshima Univ.)

[29P-am296] Effect of Nattokinase on the pathological conditions in streptozotocin induced diabetic rats

○Moe Yamaguchi¹, Ryo Fukuyama¹, Mitsugu Fujita¹ (1. Grad. Sch. Pharm. Sci., Hiroshima Int. Univ. Grad. Sch.)

[29P-am297S] Bacterial translocation in mice treated with clarithromycin in juvenile
-Investigation of abnormalities involved in developmental disorders-

○Taisuke Hirakawa¹, Momoka Ishihara¹, Nana Niimi¹, Ayami Kita¹, Ryota Araki¹, Takeshi Yabe¹ (1. Fac. Pharmaceut. Sci., Setsunan Univ.)

[29P-am298S] Effects of Hochuekkito on clarithromycin-induced social and ileal immuno deficits

○Momoka Ishihara¹, Taisuke Hirakawa¹, Niimi Nana¹, Ayami Kita¹, Ryota Araki¹, Takeshi Yabe¹ (1. Fac. Pharmaceut. Sci., Setsunan Univ.)

[29P-am299] Influence of mTOR signaling on periodic gene expression analysis in cultured cancer cells.

○Hiroyuki Okazaki¹, Yasutaka Suga¹, Ayaka Ueda¹, Keijiro Midorikawa¹, Mariko Takenokuchi¹ (1. Daiichi Univ. Pharm.)

[29P-am300S] Radiosensitization effect of BACEI after γ-irradiation in cancer cells

○ZONGXIANG ZHANG¹, KEITARO NAKAMOTO¹, BARKHA SARASWAT¹, ZHONGMING GAO¹, ANKITHA VADI VELU¹, YING TONG¹, MITSUKO MASUTANI¹ (1. Dept. Molecular & Genomic Biomed., CBMM, GSBS, Nagasaki Univ.)

[29P-am301] The Role of mitochondria dynamics in oligodendrocyte differentiation

○Keiko Iwata^1,2, Hideo Matsuzaki², Masafumi Noguchi¹, Norihito Shintani¹ (1. Grad. Sch. Pharm. Sci., Wakayama Med. Univ., 2. RCCMD, Fukui Univ.)

[29P-am302S] Blindness induced reduction in the expression levels of the clock gene Bmal1 in the suprachiasmatic nucleus may cause depression-like symptoms.

○Shiho Makino¹, Hideko Sone¹, Kohsuke Hayamizu¹, Akihide Sumino¹ (1. Yokohama University of Pharmacy)

[29P-am303S] Functional analysis of iPS cell-derived neural cells from autism spectrum disorder patients with 2p16.3 deletion

○Sayaka Katayama¹, Shotaro Kawano¹, Yukiko Ayusawa¹, Manaka Otomo¹, Hotaka Fukushima¹, Daiki Miura¹, Ryota Hashimoto², Hitoshi Hashimoto^2,3,4,5,6,7, Takanobu Nakazawa^1,2 (1. Grad. Sch. of Life Sci., Tokyo Univ. Agr., 2. Dept. Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, 3. Grad. Sch. Pharmaceut. Sci., Osaka Univ., 4. United Grad. Sch. Child Dev., Osaka Univ. , 5. Div. Biosci., Inst. Datability Sci., Osaka Univ., 6. Transdimensional Life Imaging Div., Inst. Open Transdiscip. Res. Initiatives, Osaka Univ., 7. Grad. Sch. Med., Osaka Univ.)

[29P-am304S] Analgesic effects of Disulfiram on a novel cancer pain model mouse developing allodynia

○Ryoji Fujizuka^1,2, Kota Matsuura^1,2, Tasuku Hayashi^1,2, Arisa Ohta^1,2, Kosei Nagai^1,2, Daisuke Yamada², Koji Matsushima¹, Akiyoshi Saitoh², Yuya Terashima¹ (1. Grad. Sch. Biol. Sci., Tokyo Univ. of Sci., 2. Fac. Pharm. Sci., Tokyo Univ. of Sci.)

[29P-am305] Aging suppression in fibroblasts by using VIOLA MANDSHURICA FLOWER EXTRACT and LACTOCOCCUS FERMENT (derived from cherry blossom) - Stop the aging of the dermis with working on epidermis.

○Keita Shigeyama¹, Tatsuki Mikane¹, Ikuyo Sakaguchi¹, Sho Iguchi², Natsuka Uedo², Hideki Iwano², Shigetoyo Sawaki² (1. Club Cosmetics Co., Ltd., 2. Technoble Co., Ltd. )

Session information

[29P-am] Pharmacology 1

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