[29P-pm444] Risk analysis of postoperative venous thromboembolism by measurement of protein S specific activity.

○Amin Hirakawa¹, Sayaka Munemoto¹, Hinako Hatae¹, Yasuyuki Abe², Hiroyuki Kuma¹ (1. Dept. Pharm. Sci., Nagasaki International Univ., 2. Kumamoto Chuo Hosp.)

[29P-pm445] Development of new quantitative assay system for protein C, a blood coagulation regulation factor.

○Ayana Asahi¹, Ruri Someya¹, Ryo Matsuda¹, Hinako Hatae¹, Hiroyuki Kuma¹ (1. Dept. Pharm. Sci., Nagasaki International Univ.)

[29P-pm446] Genetic analysis of venous thromboembolism patient with protein C deficiency in a Japanese family.

○Mana Hadano¹, Hinako Hatae¹, Hiroyuki Kuma¹ (1. Dept. Pharm. Sci., Nagasaki International Univ.)

[29P-pm447] Examination of expression condition of normal and mutant protein C molecules

○Yuka Nakata¹, Rina Shiraki¹, Hinako Hatae¹, Hiroyuki Kuma¹ (1. Dept. Pharm. Sci., Nagasaki International Univ.)

[29P-pm448] Development of a method for measuring the blood concentration of dabigatran using peptide substrate

○MIN SUN PARK¹, Yukino Suda¹, Hinako Hatae¹, Hiroyuki Kuma¹ (1. Dept. Pharm. Sci., Nagasaki International Univ.)

[29P-pm449S] Evaluation of blood endocan level for detecting breast cancer recurrence after tumor resection

○Kentaro Daiki¹, Yoko Kanada², Aya Nagata³, Kanae Taruno⁴, Katsuhide Igarashi¹, Toshiko Yamochi⁵, Hirotaka Ota⁵, Fumiaki Sato¹, Seigo Nakamura⁴, Yoshinori Kato¹ (1. Hoshi Univ., 2. Tokyo Rosai Hospital, 3. Showa Univ. Fujigaoka Hospital, 4. Showa Univ. Hospital, 5. Showa Univ. Sch. of Med.)

[29P-pm450S] Identification of candidates for human specific adipogenesis-related factors

○Shota Watanabe¹, Ryou Koike¹, Asuka Takahashi², Kikuji Yamashita³, Takeo Iwata¹ (1. Pharm. Sci., Niigata Univ. of Pharm, 2. Grad. Sch. Pharm. Sci., Niigata Univ. of Pharm, 3. Med. Tech., Niigata Univ. of Pharm.)

[29P-pm451] Correlation of treatment response to Japanese cedar pollen SLIT and EC50 of EXiLE response

○Chisato Kurisaka¹, Takeru Sugawara², Rion Ebina¹, Miyuu Saito¹, Ryosuke Nakamura³, Katsuyo Ohashi-Doi², Haruyo Akiyama¹ (1. Fac. Pharm. Sci., 2. Torii Pharmaceutical Co., Ltd, 3. Natl. Inst. Health Sci.)

[29P-pm452] Development of in vitro allergy testing method using saliva

○Haruyo Akiyama¹, Chisato Kurisaka¹, Yuko Ogawa¹, Tomoko Ohashi¹, Noriaki Minagawa¹, Kae Harada¹, Asuka Watabe¹, Mamoru Ikemoto¹, Ryosuke Nakamura², Ryohei Yanoshita¹ (1. Fac. Pharm. Sci., Teikyo Heisei Univ., 2. Natl. Inst. Health Sci.)

[29P-pm453] Effects of ergothioneine on the early stages of wound formation in mice with skin ischemia-reperfusion injury

○Nonno Toda¹, Moeka Takahashi¹, Nanami Arao¹, Chihiro Hashimoto¹, Mao Ishida¹, Ayano Iwasaki¹, Masayuki Tanaka¹, Kentaro Nishida¹ (1. Fac. Pharm. Sci., Setsunan Univ.)

[29P-pm454] Effects of ferrostatin-1 on wound formation in mice with skin ischemia-reperfusion injury

○Nanami Arao¹, Haruka Tsuyama¹, Nonno Toda¹, Rina Mizuno¹, Takahisa Kuga¹, Kazuyuki Kitatani¹, Kentaro Nishida¹ (1. Fac. Pharm. Sci., Setsunan Univ.)

[29P-pm455] Evaluation of the effects of dexamethasone, palonosetron monotherapy and combination therapy on cisplatin-induced nausea, vomiting and anorexia using a rat evaluation system

○Sota Misumi¹, Yuka Yamamoto¹, Nanaka Miyazono¹, Kosuke Kanda¹ (1. Sch.Pharm.Sci.,Nagasaki International Univ)

[29P-pm456] Effect of anamorelin administration on cisplatin-induced nausea and vomiting, anorexia and associated weight loss in the rat evaluation system

○Nanaka Miyazono¹, Yuka Yamamoto¹, Sota Misumi¹, Kosuke Kanda¹ (1. Sch. Pharm. Sci., Nagasaki international Univ.)

[29P-pm457S] Effect of GLP-1 Receptor Agonists on Gastrointestinal Epithelial Cells

○Aoi Kato¹, Yusuke Takizawa¹, Ami Onsui¹, Shiori Kanatani¹, Atsushi Ishimura¹, Takuro Kurita¹, Takanori Nakajima¹ (1. Nihon Pharm. Univ.)

[29P-pm458S] Effect of daprodustat on the expression of metal cation-related gene in human intestinal LS-180 cell lines

○Mao Kotani¹, Masayuki Tsujimoto¹, Chihiro Matsumoto¹, Misaki Morita¹, Kohshi Nishiguchi¹ (1. Kyoto Pharm. Univ.,)

[29P-pm459] Variation of dissolution lag time of delayed-release products in dissolution test

○Hiroyuki Yoshida¹, Tokio Morita¹, Naomi Tomita¹, Aoi Inagaki¹, Yoji Sato¹ (1. National Institute of Health Sciences)

[29P-pm460S] Influence of gastrointestinal pH against oral formulation using experimental animals

○Yuhei Shimano¹, Ikumi Sugiyama¹ (1. Sch.Pharm. Iwate Med. Univ.)

[29P-pm461S] A novel evaluation model for drug-induced intestinal toxicity with crypt-derived differentiated intestinal epithelial cells as the decrease in mucin secretion

○Shota Fukada¹, Ryuto Tomabechi¹, Kazuya Maeda¹ (1. Grad. Sch. Pharm. Sci., Kitasato Univ.)

[29P-pm462S] Effect of beverage containing indigestible dextrin on intestinal absorption of poorly water-soluble drugs

○Yuka Kuba¹, Keisuke Oda¹, Aki Kato¹, Hideki Takakura¹, Nobuhiro Mori¹ (1. Fac. Pharm. Sci. hiroshima international Univ.)

[29P-pm463] Predicting oral absorption potential in human from compound information available in early stages of drug discovery

○Katsumasa Otake¹, Yuki Katagiri¹, Shiori Kuraoka¹, Asami Saito¹, Makiko Yamada¹, Kimio Tohyama¹, Toshiyuki Takanohash¹, Ryota Shigemi¹, Mutsumi Suzuki¹ (1. JPMA)

[29P-pm464] PXR antagonists decrease the MRP2 protein expression in cisplatin resistance cells

○Takanobu Nadai¹, Kana Iwagami¹, Chiharu Katayama¹, Shuichi Kishimoto¹, Shoji Fukushima¹ (1. Fac. Pharm. Sci., Kobe Gakuin Univ.)

[29P-pm465S] Functional evaluation of hepatic Mrp3 by using adeno-associated virus mediated gene delivery

○Seima Satake¹, Yusuke Masuo¹, Shotaro Yoshino¹, Yukio Kato¹ (1. Grad. Sch. Pharm. Sci., Kanazawa Univ.)

[29P-pm466] Alteration of substance transport function in the multicellular inner blood-retinal barrier spheroids under diabetic conditions

Misa Yoshisaki¹, ○Shin-ichi Akanuma¹, Yuma Tega¹, Ken-ichi Hosoya¹ (1. Grad. Sch. Med. Pharm. Sci., Univ. of Toyama)

[29P-pm467] Characteristics of taurine transport in human brain capillary endothelial cell line

Yusuke Kawauchi¹, ○Yuma Tega¹, Shin-ichi Akanuma¹, Mai Inagaki², Masanori Tachikawa², Ken-ichi Hosoya¹ (1. Grad. Sch. Med. Pharm. Sci., Univ. of Toyama, 2. Grad. Sch. Pharm. Sci., Tokushima Univ.)

[29P-pm468] Taurine transport mechanism at the rat outer blood-retinal barrier

Moegi Kimura¹, Yuma Tega¹, Shin-ichi Akanuma¹, ○Ken-ichi Hosoya¹ (1. Grad. Sch. Med. Pharm. Sci., Univ. of Toyama)

[29P-pm469] A rapid uptake assay for Organic cation transporter OCT3

○Tatsuya Kawasaki¹, Yoshiki Aikawa¹, Mina Onaga¹, Miyu Shibata¹ (1. Sch. Pharm. Pharm. Sci., Nagasaki Int. Univ.)

[29P-pm470] Effect of Rubus suavissimus S. Lee extract on OATP2B1-mediated transport of estrone-3-sulfate.

○Shuhei Takano¹, Akane Shimizu¹, Kazuya Maeda¹ (1. Kitasato Univ.)

[29P-pm471] Impact of OAT4-mediated transport on transcellular transport of angiotensin II receptor blockers

○Saki Shimizu Noguchi¹, Saori Sakakibara¹, Yu Hirahara¹, Kazuki Funahashi¹, Takeshi Masuda², Sumio Ohtsuki³, Tomohiro Nishimura¹, Masatoshi Tomi¹ (1. Facult. Pharm., Keio Univ., 2. Grad. Sch. Media and Gov., Keio Univ., 3. Facult. Life Sci., Kumamoto Univ.)

[29P-pm472S] The effects of temperature on the transport kinetics of OATP2B1 genetic variants.

○Sakura Kawai¹, Naoya Araki², Hiroki Kataoka², Ayuko Imaoka¹, Takeshi Akiyoshi^1,2,3, Hisakazu Ohtani^1,2,3,4 (1. Fac Pharm, Keio Univ, 2. Grad Sch Pharm, Keio Univ, 3. Sch Med, Keio Univ, 4. Dept Pharm, Keio Univ Hosp)

[29P-pm473S] Comparison of the transport kinetics of 4’,5’-dibromofluorescein by OATP1A2 and OATP2B1

○Naoki Sugimura¹, Nozomi Sasaki¹, Tsujii Kazunari², Ayuko Imaoka^1,2, Takeshi Akiyoshi^1,2,3, Hisakazu Ohtani^1,2,3,4 (1. Fac. Pharm. Sci., Keio Univ., 2. Grad. Sch. Pharm. Sci., Keio Univ., 3. Sch. Med., Keio Univ., 4. Dept. pharm., Keio Univ. hosp)

[29P-pm474S] Functional analysis of folate transport by OAT2

○Yuka Ogawa¹, tomoya yasujima¹, takahiro yamashiro¹, hiroaki yuasa¹ (1. Grad. Sch. Pharm. Sci., NagoyaCity Univ.)

[29P-pm475S] Analysis of bile acid-drug interaction on organic anion transporting polypeptide 2B1

○Tomoyuki Miura¹, Toshihiro Sato², Masamitsu Maekawa^1,2, Nariyasu Mano^1,2 (1. Grad. Pharm. Sci., Tohoku Univ., 2. Dept. Pharm. Sci., Tohoku Univ. Hosp.)

[29P-pm476] Basic Study of Dacarbazine Pharmacokinetics in Mice

○Miki Ushiro¹, Azusa Imanishi¹, Akiko Kiriyama¹, Shunsuke Kimura¹, Shugo Yamashita¹ (1. Doshisha Women's Univ)

[29P-pm477] Study on biodistribution of FcRn affinity-modulated antibodies.

○Takuo Suzuki¹, Noritaka Hashii¹, Akiko Ishii-Watabe¹ (1. Natl. Inst. Health Sci.)

[29P-pm478S] Effect of urate-lowering drugs on intestinal excretion of urate in rats

○Miki Kawashima¹, Minami Adachi¹, Mai Okamura¹, Kaho Kawamura¹, Yuki Yahagi¹, Hana Tsugita¹, Wataru Yoshioka², Kimiyoshi Ichida¹, Hiroshi Hasegawa¹ (1. Tokyo Univ Pharm and Life Sci, 2. Azabu Univ)

[29P-pm479S] Production of anti-human brain microvessel endothelial cells antibodies in bubble-eye goldfish

○Miku Inai¹, Mai Inagaki², Yutaka Tamaru³, Masanori Tachikawa² (1. Grad. Sch. Pharm. Sci., Tokushima Univ., 2. Grad. Sch. Biomed. Sci., DDS research center, Tokushima Univ., 3. Grad. Sch. Bioresources, Mie Univ.)

[29P-pm480S] Evaluation of drug induced kidney injury by primary culture of rat kidney slices using oxygen-permeable InnoCell^TM plate

○Risa Uno¹, Hiroshi Arakawa¹, Moeno Kadoguchi¹, Katsuhiro Esashika², Kohei Matsushita³, Jingjing Yang², Jun Takahashi², Ikumi Tamai¹ (1. Grad. Sch. Pharm. Sci., Kanazawa Univ., 2. Mitsui Chemicals, 3. National Institute of Health Sciences )

[29P-pm481] Change of plasma levels of cimetidine in rats with drug-induced kidney injury

○Yuichi Ichimura¹, Ryoko Ogawa¹, Yui Fujiyama¹, Masako Oda¹, Hiroshi Saitoh¹ (1. Health Sci. Univ. of Hokkaido)

[29P-pm482] Survey and Consideration for Tissue Distribution of Globally-Approved Oligonucleotide Therapeutics

○Mika Miyoshi^1,2, Kei Fukuhara^1,3, Naomi Tamura^1,4, Yutaka Niwayama^1,5, Yasufumi Fukano^1,6, Shunji Imai^1,7 (1. Japan Pharmaceutical Manufacturers Association, 2. Sanwa Kagaku Kenkyusho, 3. Pfizer R&D, 4. Shionogi, 5. Kyorin Pharmaceutical, 6. Nippon Boehringer Ingelheim, 7. Nippon Shinyaku)

[29P-pm483S] Significance of the ADAR-mediated regulation of human AKR1C3 expression on drug efficacy of doxorubicin

○Yutaka Tanigawa¹, Koki Morita¹, Seiya Takemoto¹, Masataka Nakano^1,2, Tatsuki Fukami^1,2, Miki Nakajima^1,2 (1. Faculty of Pharmaceutical Sciences, Kanazawa University, 2. WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University)

[29P-pm484S] Impact of miR-223p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation

○Yoshiyuki Sakai¹, Tatsuki Fukami^1,2, Shinsaku Tokumitsu¹, Shimon Nakashima¹, Masataka Nakano^1,2, Yuichiro Higuchi³, Shotaro Uehara³, Nao Yoneda³, Hiroshi Suemizu³, Miki Nakajima^1,2 (1. Faculty of Pharmaceutical Sciences, Kanazawa University, 2. WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, 3. Liver Engineering Laboratory, Department of Applied Research for Laboratory Animals, Center Institute for Experimental Animals, Kanagawa)

[29P-pm485] Octanol/water partition coefficients determined in a reverse-phase liquid chromatography as a determinant factor for pharmacokinetic parameter estimations of chemical substances

○Koichiro Adachi¹, Makiko Shimizu¹, Fumiaki Shono², Kimito Funatsu², Hiroshi Yamazaki¹ (1. Showa Pharma Univ, 2. Nara Inst Sci Tech)

[29P-pm486S] Synthesis and evaluation of water-soluble astaxanthin prodrugs

○Kohei Takahashi¹, Masato Takahashi¹, Masakiyo Hosokawa¹ (1. Graduate School of Pharmaceutical Sciences., Chiba Institute of Science)

[29P-pm487] Inflammatory cytokine-independent down-regulation of cytochrome P450 in NAFLD/NASH model mice

○Takashi Ashino^1,2, Risako Chiba³, Monami Murata³, Keita Shibata^1,2, Koji Nobe^1,2, Yoichiro Iwakura⁴, Satoshi Numazawa^1,2 (1. Showa Univ. Grad. Sch. Pharm., 2. Pharmacol. Res. Cent., Showa Univ., 3. Showa Univ. Sch. Pharm., 4. Res. Inst. Biomed. Sci., Tokyo Univ. Sci.)

[29P-pm488] Effects of glycogen synthase kinase-3 inhibitors on the expression of human UGT1As

○Miki Katoh¹, Masayuki Nadai¹ (1. Faculty of Pharmacy, Meijo University)

Session information

[29P-pm] Pathophysiology

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