Symposium

[S30] Approaches to improving human extrapolation of drug evaluation methods

Sat. Mar 30, 2024 9:45 AM - 11:45 AM [Room 304] Conference Center 304 (3F)

Organizer: Daiju Yamazaki (Div. Pharmacol., NIHS), Seiichi Ishida (Div. Appl. Life Sci., Grad. Sch. Engineer., Sojo Univ.)

In drug discovery, one of the important issues in pharmacokinetic and safety pharmacology studies at the non-clinical stage is to predict the in vivo performance of drugs with a high degree of accuracy. In order to consider the pharmacokinetics, toxicity, and safety of drugs, quantitative prediction of drug effects in vivo, especially in humans, has been attempted based on the results of in vitro experiments using cells, etc. The use of human-derived cells and the development of in silico prediction methods are improving human predictability. In order to further improve the accuracy and reliability of prediction, it is necessary to develop advanced evaluation systems using in vitro to in vivo extrapolation (IVIVE) models and microphysiological systems (MPS) that mimic the biological environment. In this symposium, researchers who are working on approaches to improve human extrapolation of drug evaluation methods will give an overview of the latest methods from their unique perspectives.

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趣旨説明：石田誠一（崇城大） (9:45 AM - 9:50 AM)

9:50 AM - 10:12 AM

[S30-1] In vitro-based pharmacokinetic predictions of food-related compounds

○Takashi Kitaguchi¹ (1. Global Food Safety Institute, Nissin Foods Holdings Co., Ltd.)

10:12 AM - 10:34 AM

[S30-2] Generation of organoids from cryopreserved human hepatocytes applicable for ADME/Tox studies

○Ryo Okada¹ (1. JSR)

10:34 AM - 10:56 AM

[S30-3] Novel screening system for biliary excretion of drugs using human cholangiocyte organoid monolayers with directional drug transport

○Takuo Ogihara¹ (1. Laboratory of Clinical Pharmacokinetics Graduate School of Pharmaceutical Sciences Takasaki University of Health and Welfare)

10:56 AM - 11:18 AM

[S30-4] Possible improvement of the increase in non-clinical evaluation predictability by in vivo imaging and MPS

○Kaoru Sato¹, Yuhji Takahashi², Ikuro Suzuki³ (1. Laboratory of Neuropharmacology, Division of Pharmacology, NIHS, 2. NIHS Animal Care Section, Division of Cellular & Molecular Toxicology, 3. Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology)

11:18 AM - 11:40 AM

[S30-5] The challenge of cardiotoxicity prediction using in vitro assay method

○Daiju Yamazaki¹ (1. Div. Pharmacol., NIHS)

総括：山崎大樹（国立医薬品食品衛生研） (11:40 AM - 11:45 AM)

Session information