[S39] Development of in vitro gut and liver models for drug discovery research -Frontiers of biomimetic systems and organoids research-

Sat. Mar 30, 2024 1:15 PM - 3:15 PM [Room 311] Conference Center 311+312 (3F)

Organizer: Ryosuke Negoro (Courage Pharm. Rits. Univ.), Sayaka Deguchi (CiRA, Kyoto Univ.)

The in vitro models that can predict a drug candidate's efficacy, pharmacokinetics, and toxicity in non-clinical studies are extremely useful tools. However, the low predictivity of conventional cell lines has been a problem.
Recently, breakthroughs in human induced pluripotent stem cells (iPS cells), organoids and genome editing technologies have led to tremendous progress in developing highly functional in vitro human cell models. Furthermore, the advent of micro-physiological system (MPS) has enabled multiple cell cultures in the physiologically relevant 3D environment (organ-on-a-chip technology) and shear stress stimulation by perfusion culture, which was difficult to achieve with conventional plastic plates. Therefore, MPS seeded with cells differentiated from human iPS cells or organoids derived from adult stem cells is attracting considerable attention as a new non-clinical in vitro model in the future. In this symposium, focusing on the intestine and liver, essential target organs in drug discovery research, young researchers will introduce the latest results on research using organoid, MPS and other engineered cells. This symposium would provide an opportunity to discuss potential application and future prospects of these models for accelerating drug discovery research.

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オーガナイザー挨拶：根来亮介（立命館大薬） (1:15 PM - 1:20 PM)

1:20 PM - 1:42 PM

[S39-1] Development of gut-on-a-chip with mucus and intestinal bacteria

○Masahiro Tsuda^1,2 (1. Grad. Sch. of Pharm. Sci., Kyoto Univ., 2. Dept. of Clin. Pharmacol. and Ther., Kyoto Univ. Hosp.)

1:42 PM - 2:04 PM

[S39-2] Generation of the small intestine tissue model using human iPS cells and microfluidic devices for pharmaceutical research

○Sayaka Deguchi¹, Kazuo Takayama^1,2 (1. CiRA, Kyoto Univ., 2. AMED-CREST)

2:04 PM - 2:26 PM

[S39-3] Construction of in vitro pharmacokinetic models using 3D-RPTEC and icHep systems

○Hiroshi Arakawa¹, Ikumi Tamai¹ (1. Faculty of Pharmaceutical Sciences, Kanazawa University)

2:26 PM - 2:48 PM

[S39-4] Human organoid redesign with the organ-specific vessels for complex disease model and DDTs

○Norikazu Saiki^1,2 (1. Tokyo Medical and Dental Univ., Institute of Research, 2. T-CiRA)

2:48 PM - 3:10 PM

[S39-5] Generation of high functional intestinal epithelial cells and hepatocytes using genome editing technology and developing the intestine-liver chip

○Ryosuke Negoro¹ (1. Courage Pharm. Rits. Univ.)

総括：出口清香（京大iPS研） (3:10 PM - 3:15 PM)