[S41] Opening new frontier in development of RNA-based medicine by elucidation of defense mechanisms against exogenous RNAs

Sat. Mar 30, 2024 1:15 PM - 3:15 PM [Room 315] Conference Center 315 (3F)

Organizer: Shin-ich Hoshino (Grad. Sch. Pharm., Nagoya City Univ.), Nobuyoshi Akimitsu (ISC, Univ. Tokyo)

Since the 130th Annual Meeting of the Pharmaceutical Society of Japan held in Okayama in 2009, we have held a total of four RNA symposia. Over the course of the conference, we have transitioned to a focus on RNA drug discovery. Initially, the symposium mainly introduced basic research, over the course of the conference, we have transitioned to a strong focus on the development of RNA-based medicine. With the success of the mRNA vaccine against SARS-CoV-2, RNA-based medicine is now attracting a great deal of attention. Therefore, this year's RNA Symposium will introduce the latest research on RNA dynamics after viral and foreign RNAs introduced into cells. In addition, the latest findings on RNA modification and liquid-liquid phase separation, which play an important role in understanding the defense against foreign and viral RNAs, will be presented. In addition, RNA bioinformatics, which is now indispensable for RNA research, will be introduced to the members. The audience will understand various methodologies required for the development of RNA-based medicine.

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オーガナイザー挨拶とオーバービュー：秋光信佳（東大アイソトープ） (1:15 PM - 1:17 PM)

1:17 PM - 1:40 PM

[S41-1] Regulation of biological responses by RNA granules containing long noncoding RNA

○Nobuyoshi Akimitsu¹ (1. Univ Tokyo, ISC)

1:40 PM - 2:03 PM

[S41-2] Epitransriptomic regulation of gene expression mediated by RNA modifications in health and disease

○Tsutomu Suzuki¹ (1. Grad. Eng., Univ. Tokyo)

2:03 PM - 2:26 PM

[S41-3] Regulation of antiviral innate immune responses by intracellular viral RNA sensors

○Mitsutoshi Yoneyama^1,2 (1. MMRC, Chiba Univ., 2. Res.Ins.Dis.Med. Chiba Univ.)

2:26 PM - 2:49 PM

[S41-4] The biological defense mechanism that suppresses exogenous mRNA expression

○Shin-ichi Hoshino¹ (1. Grad. Sch. Pharm. Sci., Nagoya City Univ.)

2:49 PM - 3:12 PM

[S41-5] Information technology to accelerate RNA drug discovery

○Michiaki Hamada^1,2,3 (1. Waseda Univ., 2. AIST, 3. Nippon Med Univ.)

総括：星野真一（名市大院薬） (3:12 PM - 3:15 PM)