[S43] Life-oriented Chemistry in Pharmaceutical Sciences (Control of Life Phenomenon with Molecular Optomanipulation)

Sat. Mar 30, 2024 1:15 PM - 3:15 PM [Room 502] Conference Center 502 (5F)

Organizer: Naoya Ieda (Grad. Sch. Pharm., Hokkaido Univ.), Taniyuki Furuyama (Nanomaterials Res. Inst. Kanazawa Univ.)

Due to recent development of optical instruments, it has become possible to control the time and space to be irradiated with a high degree of precision. Therefore, molecules that show desired bioactivity by light are expected to be used not only as life science tools, such as optogenetics, but also for new drug therapies with fewer side effects, as exemplified by photodynamic therapy and photoimmunotherapy. This year's "Life-oriented Chemistry in Pharmaceutical Sciences" will bring together as symposiasts young researchers who are trying to develop "molecular optomanipulation", the manipulation of specific molecular functions by light, for the control and treatment of various physiological activities, and we would like to provide an opportunity to introduce their cutting-edge technologies and to discuss their prospects. Specifically, the symposium will introduce technologies for manipulating biological phenomena using small molecules such as caged compounds (Ieda) and photoswitching compounds (Matsuo), manipulating apoptosis using rhodopsin (Kojima), in vivo gene modification using PA-Cre (Morikawa), and light manipulation of intracellular temperature using non-radiation inactivation (Arai). (Arai), and Furuyama and Ieda will facilitate the discussion as organizers.

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趣旨説明：家田直弥（北大院薬） (1:15 PM - 1:20 PM)

1:20 PM - 1:42 PM

[S43-1] In vivo photomanipulation of vasodilation with a caged NO

○Naoya Ieda¹ (1. Grad. Sch. Pharm. Hokkaido Univ.)

1:42 PM - 2:04 PM

[S43-2] Photoswitchable chemical tools for the regulation and control of mitotic cell division

○Kazuya Matsuo¹ (1. Kyoto Inst. of Tech.)

2:04 PM - 2:26 PM

[S43-3] Development of optogenetic techniques using photoreceptive protein rhodopsins

○Keiichi Kojima¹ (1. Grad. Sch. of Med. Dent. Pharm. Sci., Okayama Univ.)

2:26 PM - 2:48 PM

[S43-4] Utilizing PA-Cre3.0 for in vivo spatial-temporal recombination and its application in developmental biology

○Kumi Morikawa¹ (1. AIST CMB)

2:48 PM - 3:10 PM

[S43-5] Manipulation of cell functions using photothermal effect of near-infrared absorbing dyes

○Satoshi Arai¹, Takeru Yamazaki¹, Kayoko Nomura¹ (1. NanoLSI, Kanazawa Univ.)

まとめ：古山渓行（金沢大ナノマテリアル研） (3:10 PM - 3:15 PM)