[30P-am121S] Physiological role of newly found copper binding motif in cholecystokinin-8

○Yumi Nakayama¹, Ryota Kawachi¹, Nanami Kudo¹, Moe Nohara¹, Tomoaki Kumada¹, Takashi Miura¹ (1. Dept. Pharm. Sci., Int. Univ. Health and Welfare)

[30P-am122] The analysis of the seeding effects of D-isomerization of amino acids in amyloid β on fibril formation

○Takuya Murata¹, Naoko Tate¹ (1. Fac. Pharm. Sci., Teikyo Univ.)

[30P-am123S] Amyloidogenic peptide S192 from SARS-CoV-2 and its interaction with Aβ42

○Manami Yamaguchi¹, Natsuko Goda¹, Takeshi Tenno^1,2, Emi Hibino¹, Hidekazu Hiroaki^1,2,3 (1. Grad. Sch. Pharm. Sci., Nagoya Univ., 2. BeCellBar, LLC, 3. COMIT)

[30P-am124] Slight structural changes and aggregation by asparagine deamidation in γS-crystallin

○koichi kato^1,2, Tomoki Nakayoshi^3,2, Eiji Kurimoto², Akifumi Oda^2,4, Yoshinobu Ishikawa¹ (1. Facul. of Pharm. Sci., Shonan Univ. of Med. Sci., 2. Facul. of Pharm., Meijo Univ., 3. Grad. Inf. Sci., Hiroshima City Univ., 4. Inst. Prot. Res., Osaka Univ.)

[30P-am125S] Concentration quantification of ALS-causing proteins in phase-separated droplets using Raman imaging

○Mio Mizutome¹, Kohei Yokosawa¹, Shinya Tahara¹, Shinji Kajimoto^1,2, Nobuo Maita³, Masato Kato³, Takakazu Nakabayashi¹ (1. Grad. Sch. Pharm. Sci., Tohoku Univ., 2. JST PRESTO, 3. QST)

[30P-am126] LLPS and liquid-solid phase transition of RNA-binding protein fused in sarcoma variant R495X : pressure-temperature phase diagram and pressure-jump experiments

○Yutaro Shiramasa¹, Ryu Yamamoto¹, Soichiro Kitazawa², Ryo Kitahara^1,2 (1. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2. Col. Pharm., Ritsumeikan Univ.)

[30P-am127] LLPS and liquid-solid phase transition of RNA-binding protein fused in sarcoma variant R495X : fluorescence microscope observation

○Ryu Yamamoto¹, Yutaro Shiramasa¹, Soichiro Kitazawa², Ryo Kitahara^1,2 (1. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2. Col. Pharm., Ritsumeikan Univ.)

[30P-am128S] Effects of small molecules on liquid-liquid phase separation of fused in sarcoma

○Fuka Sasaki¹, Souichiro Kitazawa², Ryo Kitahara^1,2 (1. Grad. Sch. Pharm. Sci., Ritumeikan Univ., 2. Col. Pharm. Sci., Ritsumeikan Univ.)

[30P-am129] Urea suppresses and trimethylamine N-oxide enhances liquid-liquid phase separation of fused in sarcoma, a pathogenic protein of familial amyotrophic lateral sclerosis.

○Keiji Kitamura¹, Fuka Sasaki¹, Yutaro Shiramasa¹, Ryo Kitahara^1,2 (1. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2. Col. Pharm., Ritsumeikan Univ.)

[30P-am130S] Effect of spatial arrangement of cation cluster structure on DNA aggregation morphology

○Io Tsuji¹, Megumi Yabuta¹, Momona Yamane¹, Yuka Nakagawa², Kenichi Yoshikawa³, Yuko Yoshikawa³ (1. Faculty of Pharm. Sci., DWCLA Univ., 2. Institute for Chemical Research, Kyoto Univ., 3. Faculty of Life and Medical Sci., Doshisha Univ.)

[30P-am131S] Protein aggregation induced by combination of thermal and agitation

○Zekun Wang¹, Tetsuo Torisu¹, Susumu Uchiyama¹ (1. Grad. Sch. Eng., Osaka Univ.)

[30P-am132] The effects of replacement of Tyr171 with phenylalanine on photochemical properties in Halobacterium salinarum sensory rhodopsin II

○Jun Tamogami¹, Risa Matsunami-Nakamura¹, Miki Nishio¹, Takashi Kikukawa², Naoki Kamo^1,2, Toshifumi Nara¹ (1. College Pharm. Sci., Matsuyama Univ., 2. Fac. Adv. Life Sci., Hokkaido Univ.)

[30P-am133] An analysis of the secondary structure and thermal stability of Rab3A, a protein implicated in Parkinson's disease

○GENTA ITO¹, TAISUKE TOMITA², NAOKO TATE¹ (1. Faculty Pharm. Sci., Teikyo Univ., 2. Grad. Sch. Pharm. Sci., Univ. Tokyo)

[30P-am134S] Effect of membrane lipid composition on aggregation and fibril formation of Parkinson’s disease-related α-synuclein

○Hiroki Kono¹, Namba Norihiro¹, Takashi Ohgita¹, Nagao Kohjiro¹, Saito Hiroyuki¹ (1. Kyoto Pharm. Univ)

[30P-am135S] Design of novel heterorings by modifying the human 20S proteasome subunits and its application to protein integration

○Shiori Kajita¹, Fuka Ikami¹, Kana Kamiya¹, Eri Kawasaki¹, Shiori Kakiya¹, Masaki Fuijita¹, Akifumi Oda^1,2, Eiji Kurimoto¹ (1. Facl. Pharm. Meijo Univ., 2. Inst. Protein Res. Osaka Univ.)

[30P-am136S] Novel protein oligomer formation by applying domain swapping of human proteasome assembly chaperon PAC4

○Mizuki Tsubouchi¹, Yota Suzuki¹, Yuka Akiyama¹, Akifumi Oda^1,2, Eiji Kurimoto¹ (1. Facl. Pharm. Meijo Univ., 2. Inst. Protein Res. Osaka Univ.)

[30P-am137S] In vitro reconstitution of human 20S proteasome alpha ring using mutated subunits

○Kiwako Minei¹, Morihiro Kiriya¹, Chikano Souda¹, Akifumi Oda^1,2, Eiji Kurimoto¹ (1. Facl. Pharm. Meijo Univ., 2. Inst. Protein Res. Osaka Univ.)

[30P-am138] Relationship between instability in VL-VH interaction and molecular recognition in rheumatoid factor RF-TS1

Rina Takashima¹, Enami Nishizaki¹, Maruto Yamamoto¹, Makiko Kikuchi², Nobutaka Shimizu², ○Mitsunori Shiroishi¹ (1. Dept. of Biol. Sci. and Technol., Tokyo Univ. of Sci., 2. IMSS, KEK)

[30P-am139S] Effects of arginine counterions on IgG aggregation

○Kenshiro Ariki¹, Masakazu Fukuda¹, Toru Takarada¹, Kanako Takahashi², Shunsuke Saito², Masafumi Tanaka¹ (1. Kobe Pharm. Univ., 2. Synplogen Co., Ltd.)

[30P-am140S] Analyses of the interactions between liposomes and soluble colonization factor secreted from enterotoxigenic Escherichia coli

○Shinya Ichioka¹, Minato Iimori¹, Hiroya Oki², Tomoya Imai³, Shigeaki Matsuda², Tetsuya Iida^2,4, Takuya Yoshida¹, Tadayasu Ohkubo^1,4, Shota Nakamura^2,4, Kazuki Kawahara^1,4 (1. Grad. Sch. Pharm. Sci., Osaka Univ., 2. RIMD, Osaka Univ., 3. RISH, Kyoto Univ., 4. CiDER, Osaka Univ.)

[30P-am141S] Evaluation of Ligand Binding Ability of GPCRs Sollubilized with Novel Phospholipid Derivatives

○Haruka Hoshi¹, Kenichi Kawano¹, Takahiro Fujiwara², Yousuke Yamaoka^1,3, Yusuke Kuroda¹, Kiyosei Takasu¹, Katsumi Matsuzaki¹ (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. WPI-iCeMS, Kyoto Univ., 3. Fac. Pharm. Sci., Hyogo Med. Univ.)

[30P-am142S] Evaluation of phospholipid composition control mechanism focusing on the localization of biosynthetic enzymes

○Yurika Hiraoka¹, Tomoka Miyata¹, Kohjiro Nagao¹, Hiroyuki Saito¹ (1. Kyoto Pharm. Univ.)

[30P-am143] Correlation between cell membrane damage and photoinactivation on Candida by photosensitizers

○Hisato Kato¹, Rio Toshimori¹, Kazufumi Masuda¹ (1. Sch. Pharm., Shujitsu Univ.)

[30P-am144] Effect of conformational constraints on apolipoprotein E-derived amphipathic peptide: insight into cell membrane penetration

○YUKI TAKECHI-HARAYA¹, Takashi Ohgita², Akiko Usui¹, Kazuchika Nishitsuji^3,4, Kenji Uchimura⁴, Yasuhiro Abe¹, Ryuji Kawano⁵, Monika I Konaklieva⁶, Mart Reimund⁷, Alan T Remaley⁷, Yoji Sato¹, Ken-ichi Izutsu⁸, Hiroyuki Saito² (1. Division of Drugs, National Institute of Health Sciences, 2. Kyoto Pharmaceutical University, 3. Wakayama Medical University, 4. UMR 8576 CNRS, Université de Lille, 5. Tokyo University of Agriculture and Technology, 6. American University, 7. National Institutes of Health, 8. International University of Health and Welfare)

[30P-am145S] Effect of monounsaturated fatty acid-containing phospholipids on high-density lipoprotein formation by ABCA1

○Mayu Matsuo¹, Norihiro Namba¹, Kohjiro Nagao¹, Hiroyuki Saito¹ (1. Kyoto Pharm.Univ.)

[30P-am146S] Development of Lipid Scrambling Peptides with Different Phosphatidylserine Exposure Activities

○Sota Shibasaki¹, Hiroyuki Nakao¹, Keisuke Ikeda¹, Minoru Nakano¹ (1. Toyama Univ.)

[30P-am147S] Selective anticancer activities of low pH-responsive anticancer peptides and a peptide−anticancer drug conjugate

○Aoi Taniguchi¹, Kenichi Kawano¹, Katsumi Matsuzaki¹ (1. Grad. Sch. Pharm. Sci., Kyoto Univ.)

[30P-am148] Investigation of lipid peroxidation by cold atmospheric pressure plasma irradiation.

○Tokuko Takajo¹, Aya Yokozeki¹, Kazunori Tsuchida¹, Kazunori Anzai¹ (1. Nihon Pharm. Univ.)

[30P-am149S] Regulation of phospholipid fatty acid composition by carbonic anhydrase

○Kana Matsumoto¹, Kohjiro Nagao¹, Hiroyuki Saito¹ (1. Kyoto Pharm. Univ.)

[30P-am150S] Label-free evaluation of supersulfides in living cells using Raman microscopy

○Keisuke Koga¹, Shinji Kajimoto^1,2, Shinya Tahara¹, Takakazu Nakabayashi¹ (1. Grad. Sch. Pharm. Sci., Tohoku Univ., 2. JST PRESTO)

[30P-am151S] Development of a lipid radical probe applicable to click chemistry

○Sota Kawano¹, Moe Tanaka², Kota Saito², Yuta Matsuoka³, Kazushi Morimoto², Mirinthorn Jutanom², Ken-ichi Yamada² (1. Fac. Pharm. Sci., Kyushu-u Univ., 2. Grad. Sch. Pharm. Sci., Kyushu-u Univ., 3. Grad. Sch. Med. Kyoto Univ.)

[30P-am152S] Para-Substituent Effects on Reactivity Toward Ascorbate of 4-Oxo-TEMPO Derivatives Containing Phenyl Group at the C-2 Substituent

○Karin Nagahama¹, Toshihide Yamasaki¹, Kohei Sano¹, Takahiro Mukai¹ (1. Kobe Pharm. Univ.)

[30P-am153] Role of acidic amino acid residues in the pH-dependent conversion mechanism of substrate binding energy in the multidrug efflux transporter EmrE from Escherichia coli.

○Kazumi Shimono¹, Shuichi Miyamoto¹, Seiji Miyauchi² (1. Fac. Pharm. Sci., Sojo University, 2. Fac. Pharm. Sci., Toho University)

[30P-am154S] Development of pH-sensitive fusogenic peptides for cytosolic delivery of therapeutic molecules

○Yuki Shibahara¹, Ikuhiko Nakase² (1. Sch. Sci., Coll. Life, Env. Adv. Sci., Osaka Prefecture Univ., 2. Grad. Sch. Sci., Osaka Metropolitan University.)

[30P-am155S] Exosomal membrane modification of arginine-richpeptides using curvature-recognition peptides forenhanced intracellular delivery

○Miho Nakabo¹, Kenichi Kawano², Daisuke Fujiwara^1,3, Masataka Michigami^1,3, Katsumi Matsuzaki², Ikuo Fujii^1,3, Ikuhiko Nakase^1,3 (1. Sch. Sci., Coll. Life, Env. Adv. Sci., Osaka Prefecture Univ., 2. Grad. Sch. Pharm. Sci., Kyoto Univ., 3. Grad. Sch. Sci., Osaka Metropolitan University)

[30P-am156] Evaluation of an inkjet-based technology for cytosolic delivery of therapeutic molecules using cell-penetrating peptides

Mika Omura¹, ○Sohei Ninomiya², Yoshimasa Kawaguchi³, Daisuke Fujiwara^1,2, Masataka Michigami^1,2, Tomoka Takatani-Nakase⁴, Ikuo Fujii^1,2, Shiroh Futaki³, Ikuhiko Nakase^1,2 (1. Grad. Sch. Sci., Osaka Metropolitan University, 2. Coll. Life Env. Adv. Sci., Osaka Prefecture University, 3. Inst. Chem. Res., Kyoto Univ., 4. Dep. Pharm. Mukogawa Women's Univ.)

[30P-am157S] Degradation of organic dyes by TiO₂ photocatalyst with metal nanoparticles and their electrochemical evaluation

○Taichi Yuri¹, Yuto Takenaka¹, Akira Kawashima¹, Shigeru Kohtani¹ (1. Hyogo Medical Univ.)

[30P-am158S] Investigation of surface condition of mesoporous silica-coated TiO₂ for efficient adsorption and photocatalytic degradation of organic molecules

○Sayaka Ikeda¹, Honoka Yuasa¹, Yukiko Kajimoto¹, Akira Kawashima¹, Shigeru Kohtani¹ (1. Hyogo Medical Univ.)

[30P-am159S] Improvement of Volatile Organic Compound Degradation Activity by Calcination of Mesoporous Silica-Coated Titanium Dioxide

○Tomoya Murata¹, Rina Aoki¹, Akira Kawashima¹, Shigeru Kohtani¹ (1. Hyogo Medical Univ.)

[30P-am160S] Relationship between Chiral Co-Adsorbents and Titanium Oxide Crystals in the Photocatalytic Hydrogenation of Aromatic Ketones

○Mikako Tatsuta¹, Yuta Uchiyama¹, Genki Negoro¹, Akira Kawashima¹, Hideto Miyabe¹, Shigeru Kohtani¹ (1. Hyogo Medical Univ.)

[30P-am161S] Photocatalytic Reduction of Cyclohexenone by Titanium Dioxide

○Yusuke Oka¹, Akira Kawashima¹, Shigeru Kohtani¹ (1. Hyogo Medical Univ.)

[30P-am162S] Composite of different rare earth fluoride nanocrystals and their photocatalytic activity

○Akito Tonosaki¹, Naoki Nogami¹, Makoto Kitayama¹, Akira Kawashima¹, Shigeru Kohtani¹ (1. Hyogo Medical Univ.)

[30P-am163S] Synthesis of rare-earth fluoride nanocomposites doped with luminescent species and enhancement of their luminescent properties.

○Reo Tokunaga¹, Makoto Kitayama¹, Akira Kawashima¹, Shigeru Kohtani¹ (1. Hyogo Medical Univ.)

[30P-am164] Photodegradation of environmental mutagens and photoscission of DNA by xanthene dyes as photosensitizers through LED-light irradiation

Hideki Miyagi¹, Nobumitsu Ura¹, Mami Maita¹, Naoki Mitarai¹, Masahiko Inoguchi¹, Hisato Kato², Kazufumi Masuda², ○Junichi Odo^1,2 (1. Fac. SCI., Okayama Uni. Sci., 2. Sch. Pharm., Shujitsu Univ.)

[30P-am165] Photoinduced cytotoxicity caused by photochromic diarylethene

Yuma Nakagawa¹, Kimio Sumaru², Kana Morishita², Keita Kirito³, ○Satoshi Yokojima⁴, Yuki Sakamoto⁵, Shinichiro Nakamura⁶, Kingo Uchida⁷ (1. Mol. Eng. Inst., Shiga Univ. Med. Sci., 2. AIST, 3. Faculty of Med., Univ. of Yamanashi, 4. Sch. Pharm., Tokyo Univ. Pharm. & Life Sci., 5. RIKEN, 6. Kumamoto Univ., 7. Faculty of Sci. & Tech., Ryukoku Univ.)

[30P-am166] Preparation of colon-targeting drug delivered polymeric prodrug of Diclofenac synthesized by mechanochemical solid-state polymerization.

○Yukinori Yamauchi¹, Naoki Doi², Shin-ichi Kondo², Yasushi Sasai³, Masayuki Kuzuya⁴ (1. Department of Pharmaceutical Physical Chemistry, College of Pharmaceutical Sciences, Matsuyama University, 2. Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, 3. Gifu University of Medical Science, 4. Department of Health & Welfare, Chubu Gakuin University)

[30P-am167] Development of aggregation-induced emission organic molecules for application in photodynamic therapy

○Masayori Hagimori¹, Tatsusada Yoshida², Fumiko Hara¹, Shinya Takada¹, Yukiko Ogawa², Keitaro Tanaka³ (1. Sch. Pharm., Mukogawa Women’s Univ., 2. Fac. Pharm. Sci., Nagasaki Int. Univ., 3. Shimonoseki Med. Ctr)

[30P-am168] Discovery of novel DPP8 inhibitors by fragment-based approach

○Shin-ichiro Ozawa¹, Momoka Yada¹, Ruri Sasaki¹, Nobutada Tanaka¹ (1. Sch. Pharm., Kitasato Univ.)

[30P-am169S] Improvement of the method for 3D image creation of crude drug specimens by photogrammetry

○Ryo Morishima¹, Isamu Aizawa¹, Tadahiro Yahagi¹, Tomoko Takamiya¹, Keichi Matsuzaki¹, Koji Kobayashi¹ (1. NIHON Univ.)

[30P-am170S] Introduction of the comparison scale in 3D image of crude drug specimens by photogrammetry

○Isamu Aizawa¹, Ryou Morishima¹, Tadahiro Yahagi¹, Tomoko Takamiya¹, Keiichi Matsuzaki¹, Koji Kobayashi¹ (1. School of Pharmacy, Nihon university)

[30P-am171] Signaling mechanisms regulating actin dynamics in mast cell activation

○Ruriko Suzuki¹, Yoshikazu Inoh², Satoru Yokawa², Tadahide Furuno², Naohide Hirashima¹ (1. Grad. Sch. Pharm. Sci., Nagoya City Univ., 2. Sch. Pharm., Aichi Gakuin Univ.)

[30P-am172] A formulation using an insulin prodrug for avoiding hypoglycemia

○Satoshi Kitaoka¹, Ryusei Ando¹, Kaede Kobayashi¹, Mako Okabe¹, Chisato Mori¹, Miho Koita¹, Minori Kojima¹, Hiroki Koyama¹, Yuya Egawa¹ (1. Faculty of Pharmacy and Pharmaceutical Sciences, Josai University)

[30P-am173] Investigation of a potentiation mechanism of a spin probe, TEMPOL, on the cytotoxicity of vitamin K₃

○Shoko Okazaki¹, Kanako Kobayashi¹, Risako Tashiro¹, Mai Kaieda¹, Maiko Noshita¹, Yuhei Ohta¹, Keizo Takeshita¹ (1. Fac. of Pharm. Sci., Sojo Univ.)

[30P-am174] Development of novel DNA methyltransferase assay using FRET

○Misato Ikeshita¹, Seitaro Kamiya¹, Tsutomu Kabashima¹ (1. Nagasaki International Univ.)

[30P-am175] Preparation of Ketoprofen-Containing Nanoparticle Formulations Using a Combination of Roll Mill and Ultrasonic Homogenizer

○Momo Itokazu¹, Tsutomu Kabashima¹, Haruka Ide¹, Seitaro Kamiya¹ (1. Nagasaki international Univ.)

Session information

[30P-am] Structure, physical property, and reactivity of biological materials/Biopolymers/Biological membrane and artificial model membrane/Physical measurement /Membrane transport/Photochemistry, plasma chemistry

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