[30P-am213] PVHD303, a quinazoline derivative, suppresses pathological retinal angiogenesis.

○Akane Morita¹, Ryota Ito², Chinatsu Negishi¹, Yui Tanaka¹, Yumiko Suzuki², Tsutomu Nakahara¹ (1. Kitasato Univ. Sch. Pharm. Sci., 2. Fac. Sci. Technol., Sophia Univ.)

[30P-am214] Mechanism of inhibitory effects of eicosapentaenoic acid (EPA) on coronary and basilar artery contractions: Potential antagonism on prostanoid TP receptors

○kento yoshioka¹, Keisuke Obara ¹, Shunya Oikawa ¹, Kohei Uemura ¹, Akina Yamaguchi ¹, Kazuki Fujisawa ¹, Hitomi Hanazawa ¹, Miki Fujiwara ¹, Taison Endoh ¹, Taichi Suzuki ¹, Montserrat De Dios Regadera¹, Daichi Ito¹, Noboru Saitoh ¹, Yutaka Nakagome¹, Toma Yamashita¹, Mayu Kiguchi¹, Yuka Saito¹, Yuri Nakao¹, Hinako Miyaji ¹, Guanghan Ou ¹, Keyue Xu¹, Yoshio Tanaka ¹ (1. Grad. Sch. Phar. Sci., Toho Univ.)

[30P-am215S] Positive chronotropic and tracheal relaxant effects of the β₃-adrenoceptor agonist mirabegron.

○Nana Kashimoto¹, Koto Furuyama¹, Kazuha Okawa¹, Sayaka Etani¹, Rikako Kobayashi¹, Haruna Kanae¹, Kazuo Noguchi¹ (1. Sch. Pharm. Sci., Mukogawa Women's Univ.)

[30P-am216S] Chronotropic and inotropic effects of sudachitin, a polymethoxyflavone from the peel of Citrus sudachi on isolated rat atria.

○Saki Umeda¹, Misaki Goma¹, Chinami Ueda¹, Sawako Tabira¹, Koto Furuyama¹, Mirai Taniguchi¹, Aino Nagai¹, Haruna Kanae¹, Kazuo Noguchi¹ (1. Sch. Pharm. Sci., Mukogawa Women's Univ.)

[30P-am217] Effects of the uremic toxin kynurenine on vascular function

○keisuke nakagawa¹, fumika kobayashi¹, yoshiki kamei¹, masashi tawa¹, mamoru ohkita¹ (1. Fac. Pharm., Osaka Medical and Pharmaceutical Univ.)

[30P-am218] Varenicline, a smoking cessation drug, inhibits formation of abdominal aortic aneurysm via α7 nicotinic acetylcholine receptors.

○Koshun Inada¹, Mitsuhisa Koga², Ayano Yamada², Atsushi Yamauchi¹ (1. Dept. Pharmaceut. Care and Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2. Dept. Drug Delivery, Fac. Pharmaceut. Sci., Fukuoka Univ.)

[30P-am219] Menaquinone-4 inhibits oxLDL uptake in macrophages by expression of decreasing scavenger receptor and attenuates the atherosclerotic plaque formation in ApoE KO mice

○Ayano Yamada¹, Mitsuhisa Koga¹, Daisuke Watase¹, Shotaro Goto¹, Syuichi Setoguchi¹, Kazuhisa Matsunaga¹, Jiro Takata¹ (1. Fac. Pharmaceut. Sci., Fukuoka Univ.)

[30P-am220S] Effects of purine receptor blockade on myocardial ischemia symptoms developed during anaphylaxis induction in rats.

○Haruto Funaki¹, Hiroki Nagai¹, Hina Matsukawa¹, Seiichiro Kano¹ (1. Hokkaido University of Science)

[30P-am221S] Effects of suramin administration on H-FABP levels in left ventricular myocardium during symptomatic myocardial ischemia induced by anaphylaxis in rats

○Hiroki Nagai¹, Hina Matsukawa¹, Haruto Funaki¹, Seiichiro Kano¹ (1. Hokkaido university of science)

[30P-am222] Nalmefene, a reducing alcohol consumption drug, progresses vascular calcification in smooth muscle cells

○Miyu Kinoshita¹, Ayano Yamada¹, Koshun Inada¹, Mitsuhisa Koga¹ (1. Fac. Pharmaceut. Sci., Fukuoka Univ.)

[30P-am223] Delivery of menahydroquinone-4 to smooth muscle cells inhibits vascular calcification.

○Ririka Tomita¹, Mitsuhisa Koga¹, Ayano Yamada¹, Daisuke Watase¹, Shotaro Goto¹, Shuichi Setoguchi¹, Kazuhisa Matsunaga¹, Jiro Takata¹ (1. Fac. Pharmaceut. Sci., Fukuoka Univ.)

[30P-am224] Effects of Menahydroquinone-4 Prodrug on inflammation in macrophage

○Sora Emura¹, Mitsuhisa Koga¹, Ayano Yamada¹, Daisuke Watase¹, Shotaro Goto¹, Shuichi Setoguchi¹, Kazuhisa Matsunaga¹, Jiro Takata¹ (1. Fac. Pharmaceut. Sci., Fukuoka Univ.)

[30P-am225] Menaquinone-4 inhibits the formation of abdominal aortic aneurysm in model mice.

○Sakura Kadomatsu¹, Mitsuhisa Koga¹, Ayano Yamada¹, Daisuke Watase¹, Jiro Takata¹ (1. Fac. Pharmaceut. Sci., Fukuoka Univ.)

[30P-am226S] TRPM2 contributes to the progression of TNBS-induced colitis via Th1/Th2-mediated immune responses

○Mao Kinoshita¹, Tomohiro Nakamoto¹, Kenjiro Matsumoto^1,2, Yasuo Mori³, Hiroyuki Yasuda¹, Shinichi Kato¹ (1. Kyoto Pharmaceutical University, 2. Doshisha Women’s College of Liberal Arts, 3. Kyoto University)

[30P-am227S] Effect of ginger-derived polyphenols on intestinal motility in mice

○Koki Dohi¹, Ryo Takenaka², Naoki Nakamura², Hiroyuki Yasuda¹, Kenjiro Matsumoto¹, Shinichi Kato¹ (1. Kyoto Pharmaceutical University, 2. Food Technology Laboratory, Ikeda Food Research Co., Ltd.)

[30P-am228S] Peptidylarginine deiminase 2 contributes to TNBS-induced colitis in mice

○Yu Fujiwara¹, Reiko Hara¹, Natsuki Kitamura ¹, Michiko Saito², Hiroyuki Yasuda¹, Kenjiro Matsumoto^1,3, Shinichi Kato¹ (1. Kyoto Pharmaceutical University, 2. Bioscience Research Center, Kyoto Pharmaceutical University, 3. Doshisha Women’s College of Liberal Arts)

[30P-am229] Development of an in vitro evaluation system for the effect of a co-culture between lactic acid bacteria and human iPS cell-derived intestinal cells on intestinal barrier function.

○Yuka Shimizu¹, Yuri Imai¹, Kyosuke Kobayashi², Isamu Ogawa^1,3, Takahiro Iwao^1,3, Toshihiro Sashihara², Tamihide Matsunaga^1,3 (1. Fac. Pharm. Sci., Nagoya City Univ., 2. Food Microbiology and Function Research Laboratories, R&D Division, Meiji Co., Ltd., 3. Grad. Sch. Pharm. Sci., Nagoya City Univ.)

[30P-am230S] Thermosensitive TRPM8 plays a protective role in the pathogenesis of DSS-induced colitis in mice

○Akari Sato¹, Kenjiro Matsumoto^1,2, Tomohiro Nakamoto¹, Hiroyuki Yasuda¹, Shinichi Kato¹ (1. Kyoto Pharmaceutical University, 2. Doshisha Women’s College of Liberal Arts)

[30P-am231S] Relationship between allyl isothiocyanate-induced mucosal vascular permeability and gastric motility impairment in rodents -the effect of aprepitant-

○Nanami Ishida¹, Shoki Kawasaki¹, Ryohei Mochizuki¹, Horie Syunji¹, Kimihito Tashima¹ (1. Fac Pharm Sci, Josai International Univ)

[30P-am232S] Gene and protein expressions of molecular chaperone Osp94 exposed to hyperosmotic stress in gastrointestinal cell, STC-1cells

○Ru Kojima¹, Honomi Shirasuna¹, Ryoji Kojima¹ (1. Lab. Anal. Pharmacol. Pharm. Meijo Univ.)

[30P-am233] Effect of habitual chewing on the colon and masseter muscle functions in mice

○Fukie Yaoita¹, Hiroki Ijima¹, Moe Komatsuda¹, Yuki Hariu¹, Koichi Tan-No¹ (1. Fac. of Pharm. Sci., Tohoku Med. & Pharm. Sci. Univ.)

[30P-am234] Lawsone can suppress liver fibrosis by attenuating YAP signals.

○Tsutomu Matsubara¹, Atsuko Daikoku¹, Misako Sato-Matsubara², Hideto Yuasa¹, Hayato Urushima¹, Norifumi Kawada¹, Kazuo Ikeda¹ (1. Grad. Sch. Med., Osaka Metropolitan Univ., 2. Grad. Sch. Vet. Sci., Osaka Metropolitan Univ.)

[30P-am235S] Roles of IVA-type phospholipase A₂in sinusoidal endothelial cells and hepatic stellate cells in the development of NASH.

○Taichi Nishizaki¹, Eri Kawashita¹, Keiichi Ishihara¹, Saki Kishinaka¹, Ayumi Mizota¹, Satoshi Akiba¹ (1. Kyoto Pharm. Univ.)

[30P-am236] Identification of herbal medicines contributing to the anti-obesity effect of Hachimijiogan

○Syota Kagawa¹, Yusuke Touyama¹, Taiki Fujimori¹, Hana Akashi¹, Mako Yokoyama¹, Kakuyou Ogawa¹, Fumihiro Nagashima¹ (1. Daiichi University of Pharmacy)

[30P-am237] Investigation of electrophysiological assay for evaluating drug responsiveness of MIN6 cells and islets to insulin secretion using micro electrode array.

○Hitomi Hirose¹, Hideo Saotome¹, Katsuharu Tsuchida¹, Keishiro Nishimura¹, Izumi Yamashita¹, Hideki Endo¹, Yoichi Yasunami¹, Masahito Matsumoto¹, Keiichi Shirakawa^2,3, Kanako Sakaeda⁴, Yasuhiro Irino⁴, Yasushi Okazaki¹ (1. Grad. Sch. Med., Juntendo Univ., 2. SCREEN Holdings Co., Ltd., 3. Alpha MED Scientific Inc., 4. SYSMEX CORPORATION)

[30P-am238S] Increase in litter size and augmented expression of receptor tyrosine kinase in the ovaries of obesity-resistant ddY-L mice.

○Minaho Takahashi¹, Mizuki Fuchi¹, Aoi Miwa¹, Haruka Kanbara¹, Mahiro Yoshida ¹, Yu Fujita ¹, Jyunya Fujimori ¹, Toshio Maeda ², Yoshiyuki Kagawa ², Yoshiyuki Tanabe ¹ (1. Yokohama Univ. Pharm., 2. Univ. Shizuoka Sch. Pharm. Sci.)

[30P-am239] Omics data-based analysis of non-alcoholic fatty liver disease pathogenesis

○Kazuma Hamada¹ (1. Fac. Pharm. Sci., Teikyo Heisei Univ.)

[30P-am240S] Study of elevated blood glucose levels and glucose uptake in ovariectomized mice.

○Momoka Urayama¹, Satoru Mitazaki¹, Mamoru Fukuchi¹ (1. Fac. of Pharm., Takasaki Univ. of Health and Welfare)

[30P-am241] Does prostaglandin E₂ facilitate NAFLD/NASH development?

○Takeo Nakanishi¹, Rattiporn Boonnop¹, Saaya Hirata¹, Yoshinobu Nakamura¹ (1. Faculty of Pharmacy, Takasaki University of Health and Welfare)

[30P-am242S] Identification of cell autonomous oscillators in adrenal zona glomerulosa cells

○Tomohiro Otani¹, Takahito Miyake¹, Masao Doi¹ (1. Grad. Sch. of Pharm. Sci., Kyoto Univ.)

[30P-am243S] IRBIT is a regulator of browning of white adipose tissue.

○Yurika Ito¹, Koichi Hamada¹, Hiromi Takamura¹, Ayano Ohashi¹, Nanami Sugaya¹, Iori Yamamoto¹, Yasuaki Goto², Katsuhiko Mikoshiba³, Hiroyuki Kojima⁴, Akihiro Mizutani¹ (1. Showa Pharmaceutical Univ., 2. Grad. Sch. Pharm. Sci., Showa Pharm. Univ., 3. ShanghaiTech Univ., 4. Rockefeller Univ.)

[30P-am244] Regulation of energy metabolism via Growth hormone signaling

○Mana Mitsutani¹, Mei Yokoyama¹, Hiromi Hano¹, Tomomi Fujikawa¹, Midori Matsushita¹, Aoi Morita¹, Asuka Hamamoto¹, Kumi Futawaka², Tetsuya Tagami², Kenji Moriyama^1,2 (1. Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 2. Clinical Research Institute for Endocrine and Metabolic Diseases, National Hospital Organization Kyoto Medical Center)

[30P-am245S] Examination of upper factors of GATA1,2 in blood cells.

○Tomomi Fujikawa¹, Mana Mitsutani¹, Midori Matsushita¹, Mei Yokoyama¹, Aoi Morita¹, Hiromi Hano¹, Asuka Hamamoto¹, Kumi Futawaka¹, Tetsuya Tagami², Kenji Moriyama^1,2 (1. Pharm., Mukogawa Women’s University, 2. National Hospital Organization Kyoto Medical Center)

Session information

[30P-am] Pharmacology 3