[31-304-pm] ADME, PK/PD

Sun. Mar 31, 2024 1:15 PM - 2:15 PM [Room 304] Conference Center 304 (3F)

Chair: Kiyomi Ito, Kaoru Kobayashi

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1:15 PM - 1:27 PM

[31-304-pm01] Transfer of the biological barriers of anti-COVID-19 drugs molnupiravir, Paxlovid, and the gender effect in rats

○Tung-Hu Tsai¹, Wan-Hsin Lee¹, Chun-Hao Chang¹ (1. National Yang Ming Chiao Tung University, Taipei, Taiwan)

1:27 PM - 1:39 PM

[31-304-pm02] Physiologically-based pharmacokinetic model analysis of coproporphyrin I/III disposition in rats

○Yukana Tomoda¹, Takashi Yoshikado¹, Kanna Nagata¹, Kenji Okada¹, Mikako Oka¹, Koji Chiba¹ (1. Yokohama Univ. Pharm.)

1:39 PM - 1:51 PM

[31-304-pm03S] PBPK model analysis of sitagliptin nonlinear pharmacokinetics focusing on DPP-4 expression and DPP-4-mediated reabsorption mechanism

○Yui Suzuki¹, Takashi Yoshikado¹, Ryo Nakamura¹, Kenji Okada¹, Mikako Oka¹, Koji Chiba¹ (1. Yokohama Univ. Pharm.)

1:51 PM - 2:03 PM

[31-304-pm04] Cilazapril physiologically based pharmacokinetic model with binding to target proteins to predict the occupancy

○Jun Chimura^1,2, Ryuhei Seta¹, Takeyuki Magome¹, Takashi Yoshikado¹, Kenji Okada¹, Mikako Oka¹, Koji Chiba¹ (1. Yokohama Univ. Pharm., 2. Certara G.K.)

2:03 PM - 2:15 PM

[31-304-pm05S] Development of lisinopril physiologically based pharmacokinetic model with nonlinear binding to target proteins: Exploring factors of nonlinearity

○Ryuhei Seta¹, Takeyuki Magome¹, Takashi Yoshikado¹, Kenji Okada¹, Mikako Oka¹, Koji Chiba¹ (1. Yokohama Univ. Pharm.)

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