[31-311-am] Genetic drug delivery system 1

Sun. Mar 31, 2024 8:30 AM - 9:30 AM [Room 311] Conference Center 311+312 (3F)

Chair: Makiya Nishikawa, Hidemasa Katsumi

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8:30 AM - 8:42 AM

[31-311-am01S] Impact of pre-existing antibody against PEG on the efficacy of spike mRNA-loaded LNP following i.m. injection

○Haruka Takata^1,2, Shunji Abe¹, Taro Shimizu³, Hidenori Ando^1,2, Tatsuhiro Ishida^1,2 (1. Grad. Sch.Pharm. Sci., Tokushima Univ., 2. Institute of innovative DDS, Tokushima Univ., 3. RIMD, Osaka Univ.)

8:42 AM - 8:54 AM

[31-311-am02S] Efficient knock-down of target genes by using a CRISPR-Cas13 system-expressing adenovirus vector.

○Yuki Osakada¹, Tomohito Tsukamoto¹, Eiko Sakai¹, Akira Asayama¹, Fuminori Sakurai¹, Hiroyuki Mizuguchi^1,2,3,4,5 (1. Graduate School of Pharmaceutical Sciences, Osaka University., 2. National Institute of Biomedical Innovation, Health and Nutrition., 3. Global Center for Medical Engineering and Informatics, Osaka University., 4. Institute for Open and Transdisciplinary Research Initiatives, Osaka University., 5. Center for Infectious Disease Education and Research, Osaka University.)

8:54 AM - 9:06 AM

[31-311-am03] Systemic applicable Cas9-sgRNP RNP delivery systems based on polymeric ternary complexes for Cancer therapy.

○Yuto Honda^1,2,3, Takumi Matsuo^1,2, Nomoto Takahiro^1,4, Nishiyama Nobuhiro^1,2,3 (1. Lab. for Chem. and Life Sci., Tokyo Tech., 2. Dept. of Life Sci. and Tech., Tokyo Tech., 3. Innovation Center of NanoMedicine, 4. Grad. Sch. Arts Sci., Univ. Tokyo)

9:06 AM - 9:18 AM

[31-311-am04S] Amelioration of fibrosis in hepatic stellate cells by virus genome-mimicking nucleic acid medicines

○Kanako Nakagawa¹, Ikuho Ishigami², Hiroyuki Mizuguchi^1,2,3,4,5,6, Fuminori Sakurai^1,2 (1. Sch. of Pharm. Sci., Osaka Univ., 2. Grad. Sch. Pharm. Sci., Osaka Univ., 3. NIBIOHN, 4. MEI center, Osaka Univ., 5. OTRI, Osaka Univ., 6. CiDER, Osaka Univ.)

9:18 AM - 9:30 AM

[31-311-am05] Evaluation of a novel functional lipid library for highly efficient mRNA delivery

○Seigo Kimura^1,2,3, Kana Okada¹, Naoko Abe¹, Hiroshi Abe^1,4 (1. Grad. Sch. Sci., Nagoya Univ., 2. IRCCS., Nagoya Univ., 3. Gard. Sch. Pharm. Sci., Kyoto Univ., 4. iGCORE)

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