[31P-am212] Neurite outgrowth promotion in PC12 cells by 24(R)-ethyllophenol from Morus alba

○Shigeyoshi Honma¹, Kanako Handa¹, Gaku Tanaka¹, Ritsuko Mitsumata¹, Daiki Shimada¹, Shunsuke Takei¹, Kazuki Watanabe¹, Makoto Yoshida¹ (1. Fac. Pharmacy, Takasaki University of Health and Welfare)

[31P-am213] Characterization of the local field potentials in mice with visceral pain

○Tasuku Kayama¹, Atsushi Tamura¹, Xiaoying Tuo¹, Takuya Sasaki^1,2 (1. Grad. Sch. Pharm. Sci., Tohoku Univ., 2. Grad. Sch. Med., Tohoku Univ.)

[31P-am214] Analysis of ATP-responsible calcium oscillation in human iPSC-derived midbrain astrocytes

○Kaneyasu Nishimura¹, Hironobu Osaki¹, Yoshito Masamizu¹ (1. Grad. Sch. Brain Sci., Doshisha Univ.)

[31P-am215S] Visual analysis of mice escape behavior in response to looming visual stimulus ~Consider conditions and effectiveness of environmental enrichment~

○Aki Hashio¹, Shunya Nakamura², Hironobu Shuto^2,3, Toshiki Maeda², Yuki Higashitani⁴, Chieko Koike^2,4,5 (1. Col. Life Sci., Ritsumeikan Univ., 2. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 3. vision care, 4. Col. Pharm. Sci., Ritsumeikan Univ., 5. CSVS)

[31P-am216S] Generating mechanism of oscillation in the TRPM1-deficient mouse retina

○Taketo Nishimoto^1,3, Sho Horie^2,3, Konan Sakuta^1,3, Chieko Koike^1,2,3,5, Masao Tachibana^4,5 (1. Col. Pharm. Sci., Ritsumeikan Univ., 2. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 3. Laboratory for Systems Neuroscience and Developmental Biology, 4. Res. Organization of Sci. and Technology, Ctr. for Systems Vision Sci. (CSVS), 5. Center for Systems Vision Science)

[31P-am217S] Effect of maternal obesity on anxiety and social behavior in offsprings

○Nanako Asaumi¹, Tomohiro Kamata¹, Naomi Yonemochi¹, Hiroko Ikeda¹ (1. Hoshi Univ.)

[31P-am218S] Effect of nalfurafine on feeding behavior and on anorexia by anticancer drugs

○Manato Kikuta¹, Rikuo Utsugi¹, Hiroto Furuya¹, Yusuke Matsuyama¹, Naomi Yonemochi¹, Nagase Hiroshi², Hiroko Ikeda¹ (1. Hoshi Univ. , 2. WPI-IIIS, Univ. Tsukuba)

[31P-am219S] Contributions of synaptic protein functions to the mammalian sleep-wake cycle revealed by in vivo gene expression analysis

○Keita Yamamoto^1,2, Yilin Jiang², Daisuke Tone^2,3, Rikuhiro Yamada^1,2, Hiroki Ueda^1,2,3 (1. Grad. Sch. Med., Osaka Univ., 2. RIKEN BDR Ctr., 3. Grad. Sch. Med., Univ. Tokyo)

[31P-am220S] Effect of external light on methamphetamine-induced the extension of period of biological rhythm

○Keitaro Asai¹, Masataka Sebayashi¹, Naoya Shirakura¹, Kanako Hayashi¹, Saki Kawai¹, Makiko Hashimoto¹, Kazuko Hamada¹, Toshiyuki Hamada¹ (1. IUHW)

[31P-am221S] Identification of timing of brain never changes caused by methamphetamine using whisker clock gene expression

○Naoya Shirakura¹, Saki Kawai¹, Asai Keitarou¹, Hayashi Kanako¹, Sebayashi Masataka¹, Hashimoto Makiko¹, Hamada Kazuko¹, Hamada Toshiyuki¹ (1. IUHW)

[31P-am222S] Long-term in vivo measurement system for clock gene expression rhythm under light and dark conditions

○Kanako Hayashi¹, Masataka Sebayashi¹, Keitaro Asai¹, Naoya Shirakura¹, Saki Kawai¹, Makiko Hashimoto¹, Kazuko Hamada¹, Toshiyuki Hamada¹ (1. IUHW)

[31P-am223S] Diabetes severity stage determination using whisker clock gene expression

○Saki Kawai¹, Naoya Shirakura¹, Kanako Hayashi¹, Masataka Sebayashi¹, Keitarou Asai¹, Makiko Hashimoto¹, Kazuko Hamada¹, Toshiyuki Hamada¹ (1. IUHW)

[31P-am224S] Choline-deficient and methionine-depleted fatty diet (CDAHFD)-induced hepatitis potentiates reduced locomotor activity in ovariectomized mice

○Chisato Takiya¹, Ryoken Aoki¹, Masahiro Toho¹, Megumi Furukawa¹, Nobuo Izumo^1,2 (1. Yokohama University of Pharmacy, 2. General Health Medical Research Center,Yokohama University of Pharmacy)

[31P-am225S] Effects of low choline intake on spontaneous locomotion and restraint stress in the female fetus

○Ayaka Ito¹, Ryoken Aoki¹, Megumi Furukawa¹, Takayuki Manabe², Nobuo Izumo^1,3 (1. Yokohama University of Pharmacy, 2. Chukyo Gakuin University, 3. General Health Medical Research Center,Yokohama University of Pharmacy)

[31P-am226S] Changes in claustral neuron activity by the exposure to social defeat stress

○Yoshihisa Yokoyama¹, Masato Tanuma¹, Jin Ohkubo¹, Keita Miyaji¹, Kaoru Seiriki¹, Hiroshi Nomura², Hitoshi Hashimoto^1,3,4,5,6, Atsushi Kasai^1,7 (1. Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2. Dep. Cognitive Func. & Pathol., Grad Sch. Med. Sci., Nagoya City Univ., 3. Unit. Grad. Sch. Child Dev., Osaka Univ., 4. Inst. Datability Sci., Osaka Univ., 5. Open Tarnsdiscip. Res. Initi., Osaka Univ., 6. Dep. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ., 7. Systems Brain Sci. Project, Drug Innovation Center, Grad. Sch. Pharm. Sci., Osaka Univ.)

[31P-am227S] Behavioral changes in young male mice due to low fetal choline intake.

○Rena Ikeda¹, Ryoken Aoki¹, Masahiro Toho¹, Megumi Furukawa¹, Nobuo Izumo^1,2 (1. Yokohama University of Pharmacy, 2. General Health Medical Research Center,Yokohama University of Pharmacy)

[31P-am228S] Role of AMP-activated protein kinase in the hippocampus and amygdala in strengthened fear memory in diabetic mice

○Yuya Yokoe¹, Naomi Yonemochi¹, Hiroko Ikeda¹ (1. Hoshi Univ.)

[31P-am229] The effect of bone morphogenetic protein-9 on the barrier function in brain endothelial cells

○Sakurako Mori¹, Takuro Iwao¹, Hisataka Aridome¹, Miki Yokoya¹, Miho Yasunaga¹, Junko Mizoguchi¹, Yasuyoshi Tanaka¹, Huyuko Takata¹, Shinya Dohgu¹ (1. Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.)

[31P-am230] The functional characterization of Blood-Brain Barrier in senescence-accelerated prone 8
mice

○Yutaro Inoue¹, Takuro Iwao¹, Yuna Doi¹, Yasuyoshi Tanaka¹, Fuyuko Takata¹, Shinya Dohgu¹ (1. Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ)

[31P-am231] Changes in Blood-Brain Barrier permeability during the process of remyelination in a mouse model of cuprizone-induced demyelination

○Yuna Doi¹, Takuro Iwao¹, Yasuyoshi Tanaka¹, Fuyuko Takata¹, Shinya Dohgu¹ (1. Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.)

[31P-am232] Increased α-synuclein levels in the brain of mouse models of inflammatory bowel disease

○Mitsuha Takashima¹, Fuyuko Takata¹, Junko Mizoguchi¹, Takuro Iwao¹, Miho Yasunaga¹, Atsuya Oba¹, Yasuyoshi Tanaka¹, Akio Nakashima², Osamu Imakyure², Shinya Dohgu¹ (1. Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2. Department of Pharmacy, Fukuoka University Chikushi Hospital)

[31P-am233] Brain pericytes increase the expression and plasma membrane localization of MFSD2A in brain endothelial cells through PDGFB/PDGFRβ signaling pathway

○Takuro Iwao¹, Fuyuko Takata¹, Yasuyoshi Tanaka¹, Hisataka Aridome¹, Miki Yokoya¹, Miho Yasunaga¹, Junko Mizoguchi¹, Shinya Dohgu¹ (1. Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.)

[31P-am234S] Improving effect of nicotinamide nucleotide on memory impairment induced by Aβ injection

○Momoka Watanabe¹, megumi furukawa¹, yuna ishiyama², ryoken aoki¹, daichi nagashima^1,3, nobuo izumo^1,3 (1. yokohama university of pharmacy, 2. Tokyo Graduate School of pharmaceutical Science, 3. yokohama university of pharmacy general health medical senter)

[31P-am235S] Effect of PEGylated liposomalization of oxaliplatin on susceptibility of mice to chronic unpredictable mild stress in mice.

○Ayaka Akinaga¹, Ryoko Tsukube¹, Yuki Takahashi¹, Keisuke Mogi¹, Takeshi Yasukawa², Hirotoshi Morimoto², Katsuya Morito¹, Kentaro Takayama¹, Yoshinobu Uozumi², Tatsuhiro Ishida³, Kazuki Nagasawa¹ (1. Dept. Environ. Biochem., Kyoto Pharm. Univ., 2. Ako Kasei Co., Ltd., 3. Inst. of Biomed. Sci. Tokushima Univ.)

[31P-am236S] Alteration of sensitivity against chronic unpredictable mild stress in oxaliplatin- or PEGylated liposomal oxaliplatin-administered mice.

○Ryoko Tsukube¹, Ayaka Akinaga¹, Keisuke Mogi¹, Takeshi Yasukawa², Hirotoshi Morimoto², Katsuya Morito¹, Kentaro Takayama¹, Yoshinobu Uozumi², Tatsuhiro Ishida³, Kazuki Nagasawa¹ (1. Dept. Environ. Biochem., Kyoto Pharm. Univ., 2. Ako Kasei Co., Ltd., 3. Inst. of Biomed. Sci. Tokushima Univ.)

[31P-am237S] An examination of the relationship of various factors, including boredom and ADHD degree, between parents and their elementary school children.

○Tianyi Zhang¹, Izumi Uehara², Yuji Ikegaya¹ (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. Institute for Education and Human Development, Ochanomizu University)

[31P-am238] Role of TRPV1 in the development of inflammatory pain

○chizuko watanabe¹, masaru yoshizumi¹, shinobu sakurada¹, hirokazu mizoguchi¹ (1. Tohoku Med. Pharm. Univ.)

[31P-am239S] Research for abnormal behavior in PACAP receptor knockout mice and their causative genes

○Tomoki Nohara¹, Mitio Yamashita¹, Junko Shibatou^3,1, Randeep Rakwal², Hirabayashi Takahiro³, Seiji Shioda³, Humiko Takenoya¹ (1. Hoshi Univ., 2. Univ. of Tsukuba, 3. Shonan Univ. of Med. Sci.)

[31P-am240S] A behavioral paradigm for testing risk-based decision making in rats

○Fumiya Fukushima¹, Atsushi Tamura¹, Takuya Sasaki¹ (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)

[31P-am241S] Comprehensive analysis of altered hypothalamic astrocytes under the cancer cachexia state

○Ryuto Nakamura¹, Yukari Suda^1,2, Keiko Nakamura^1,3, Rion Tsukamoto^1,2,4, Mariko takeuchi¹, Fukiko Matsuyama^1,5, Yusuke Hamada^1,2, Michiko Narita², Naoko Kuzumaki^1,2, Minoru Narita^1,2 (1. Hoshi Univ., 2. Natl. Cancer Ctr. Res. Inst., 3. Natl. Cancer Ctr. Hosp., 4. Tokyo Uni. of Sci., 5. Japan Small Animal Med Ctr.)

[31P-am242] NMDA receptor was involved in the non-mammalian sPLA₂-induced neuronal cell death, but not in the mammalian sPLA₂-induced neuronal cell death.

○Tatsurou Yagami¹, Yasuhiro Yamamoto¹ (1. Dept. of Physiol., Fac. of Pharmaceut. Sci., Himeji Dokkyo Univ.)

[31P-am243] Inhibitory effect of 1-benzyl-N-propargyl-TIQ on MPTP-induced Parkinson's disease mouse model

○Yuna Shiraishi¹, Toshie Kambe², Terumasa Chiba¹, Toshiaki Saitoh¹, Kyoji Taguchi², Kenji Abe¹ (1. Nihon Pharm. Univ., 2. Showa Pharm. Univ.)

[31P-am244S] Screening of glyceraldehyde-targeted proteins and its pathological function

○Tsubasa Ogita¹, Ayako Furukawa¹, Hayahide Ooi¹, Hiroki Kato¹, Masayoshi Takeuchi², Yoshiki Koriyama¹ (1. Suzuka Univ. Med. Sci., 2. Kanazawa Med. Univ)

[31P-am245S] Prevention effects by AGEs inhibitors against axonal degeneration by TAGE-β-tubulin

○Hideyuki Nishijo¹, Hayahide Ooi¹, Ayako Furukawa¹, Masayoshi Takeuchi², Yoshiki Koriyama¹ (1. Suzuka Univ. Med. Sci., 2. Kanazawa Med. Univ)

[31P-am246S] Promotion of tau phosphorylation by glyceraldehyde (GA) in SH-SY5Y cells

○Alan Tweedy¹, Hayahide Ooi¹, Ayako Furukawa¹, Masayoshi Takeuchi², Yoshiki Koriyama¹ (1. Suzuka Univ. Med. Sci., 2. Kanazawa Med. Univ)

[31P-am247] Alterations in the expression of glutamate transporters in glyceraldehyde-treated mouse cortical astrocyte.

○ayako furukawa¹, Chisa Nishimori¹, Masayoshi Takeuchi², Yoshiki Koriyama¹ (1. Grad. Sch. and Fac. Pharm. Sci., Suzuka Univ. Med. Sci., 2. Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University)

[31P-am248S] Analysis of Aβ-induced cellular responses in a co-culture of human iPS cell-derived cortical neurons and organoids with microglial progenitors

○Momona Ando¹, Kaneyasu Nishimura², Koki Harada¹, shiho yamada¹, Ryota Iwasaki¹, Kazuyuki Takakta¹ (1. Jnt. Res. Lab., Kyoto Pharm. Univ, 2. Grad. Sch. Brain Sci., Doshisya Univ)

[31P-am249S] Distribution of Cannabinoid CB₁ and CB₂ receptor in the murine retina

○AKARI AIDA¹, Asami Mori¹, Yayoi Tsuneoka¹, Takashi Uezono¹, Kenji Sakamoto¹ (1. Fac. Pharma-Sci., Teikyo Univ.)

[31P-am250S] Effects of low phosphate on neurons

○Junya Murata¹, Yuto Murayama¹, Ayane Misima¹, Kazuki Ohuchi¹, Hisaka Kurita¹, Isao Hozumi¹, Masatosi Inden¹ (1. Fac. Pharm. Sci., Gifu Pharmaceutical Univ)

[31P-am251] Study on the onset mechanisms of Alzheimer's disease using MEGF10 knockout mouse.

○YU FUJITA¹, Tomoji Maeda², Taichi Yabe¹, Yoshikazu Yamada¹, Kun Zou³, Hiroto Komano⁴, Yoshiyuki Tanabe¹ (1. Yokohama Univ. of Pharm., 2. Nihon Pharm. Univ., 3. Nagoya City Univ., 4. Iwate med. Univ.)

[31P-am252] Involvement of iron ions in oxidative stress-induced α-synuclein aggregation and effect of IPA on the degradation system using cultured Parkinson's disease model cells.

○Tomokazu Kimura¹, Seisuke Mimori¹, Rika Sato¹, Koichi Kawada¹, Tetsuto Kanzaki² (1. Chiba institute university, 2. Chiba university)

[31P-am253S] The neuroprotective effects of activated fibroblast growth factor receptor against dipeptide repeat proteins mediated toxicity

○Taisei Ito¹, Kazuki Ohuchi¹, Hisaka Kurita¹, Hozumi Isao¹, Inden Masatoshi¹ (1. Fac. Pharm. Sci., Gifu Pharmaceutical Univ)

[31P-am254S] Identification of genes involved in the toxicity of Parkinson’s disease-associated neurotoxin MPP⁺

○Futa Suzuki¹, Masatsugu Miyara¹, Yaichiro Kotake¹ (1. Grad. Sch. Biomed and Health. Sci., Hiroshima Univ.)

[31P-am255S] Anti-aging effect of PACAP by PACAP receptor knockout mice

○Hiroto Yamaura¹, Michio Yamashita¹, Junko Shibato^1,3, Randeep Rakwal², Takahiro Hirabayashi³, Seiji Shioda³, Fumiko Takenoya¹ (1. Hoshi Univ., 2. Univ. of Tsukuba, 3. Shonan Univ. of Med. Sci.)

[31P-am256] Angiopoietin-1 mitigates disruption of the blood-brain barrier and brain edema following traumatic brain injury in mice

○Shotaro Michinaga¹, Kenta Takahashi¹, Yasuhiro Ogawa¹, Shigeru Hishinuma¹ (1. Dept. Pharmacodynamics, Meiji Pharm Univ.)

[31P-am257] Astrocyte-mediated neuroprotection by noradrenaline against chemical ischemia-induced delayed neuronal cell death in a mixed culture of neurons and astrocytes.

○Yasuhiro Yoshioka¹, Taichi Wakayama¹, Ayaka Takada¹, Yuki Ishimaru¹ (1. Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ.)

[31P-am258] Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina

○Nozomu Kirai¹, Akane Morita¹, Toshihide Kashihara¹, Tsutomu Nakahara¹ (1. Sch. Pharm. Sci., Kitasato Univ. )

[31P-am259S] Dynamics of corticoid receptor in the hippocampus during PTSD-like false context fear memory

○Yayako Karino¹, Haruka Asano¹, Kotono Midorikawa¹, Kenjiro Seki¹ (1. Dept. Pharmacol. Sch. Pharm Sci., Ohu Univ.)

[31P-am260S] The effect of ramelteon on the post-operative cognitive dysfunction in aged mice

○Erena Takeda¹, Ryuga Murakami¹, Kenjiro Seki¹ (1. Dept. Pharmacol. Sch. Pharm Sci., Ohu Univ.)

[31P-am261S] The effect of ramelteon on the isoflurane anesthesia-induced the hyperactivity and the impairment of social interaction in aged mice

○Ryuga Murakami¹, Erena Takeda¹, Kenjiro Seki¹ (1. Dept. Pharmacol. Sch. Pharm Sci., Ohu Univ.)

[31P-am262S] Kir4.1 channel inhibitor, quinacrine, ameliorates neuroinflammatory cognitive impairment

○Yuto Ishizaki¹, Saki Shimizu¹, Honatsu Seo¹, Takuma Tahara¹, Yukihiro Ohno¹ (1. Fac. Pharmacy, Osaka Med. Pharm. Univ.)

[31P-am263S] Sonic hedgehog reduces disruption of the blood-brain barrier via smoothened in TBI model mice

○Kenta Takahashi¹, Shotaro Michinaga¹, Yasuhiro Ogawa¹, Shigeru Hishinuma¹ (1. Dept. Pharmacodynamics, Meiji Pharm Univ.)

[31P-am264] Protective effect of effusol and dehydroeffusol from Juncus effusus on dopaminergic neuron death in rats after exposure to 6-hydroxydopamine

○Haruna Tamano^1,2, Misa Katahira², Nana Saeki², Atsushi Takeda² (1. Shizuoka Tohto Med. Col., 2. Sch. Pharm. Sci., Univ. Shizuoka)

[31P-am265S] Olfactory response in mouse model of autism induced by prenatal exposure to valproic acid

○Shiori Nishihara¹, Shutaro Nakashima¹, Yui Furusato¹, Rei Yamada¹, Takuya Watanabe¹, Kaori Kubota¹, Shutaro Katsurabayashi¹, Katsunori Iwasaki¹ (1. Fac. Pharm. Sci., Fukuoka Univ.)

[31P-am266S] Evaluation of olfactory response in the 5xFAD Alzheimer's disease mouse model

○Issei Sueoka¹, Takuya Watanabe¹, Kaori Kubota¹, Shutaro Katsurabayashi¹, Katsunori Iwasaki¹ (1. Fac. Pharm. Sci., Fukuoka Univ.)

[31P-am267] Effects of Uridine 5’-monophosphate Disodium Salt Intake on Cognitive Functions in Middle-Aged and Older Adults: A Randomized Controlled Trial

○Kosuke Nakagawara¹, Kazuya Ishige¹ (1. YAMASA)

[31P-am268] Therapeutic effects of N-acetyl-L-cysteine by intranasal administration combined with cell-penetrating peptide-modified polymer micelles in mouse models of neuropathic pain

○Hiroko Miyagishi¹, Takanori Kanazawa², Takumi Kurano¹, Naoto Suzuki¹, Toyofumi Suzuki¹, Yasuhiro Kosuge¹ (1. Sch. Pharm., Nihon Univ., 2. Grad. Sch. Biomed. Sci., Tokushima Univ.)

[31P-am269S] Lipid peroxidation inhibitor suppresses inflammation in a mouse model of vascular dementia

○Ryo Hagimori¹, Masami Abe², Mirinthorn Jutanom², Kazushi Morimoto², Ken-ichi Yamada² (1. Fac. of Pharm. Sci., Kyushu Univ., 2. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[31P-am270S] Roles of senescent microglia in anxiodepressive-like behaviors of aged mice

○Miku Yokohata¹, Yoki Nakamura², Keisuke Ikeda², Kazue Hisaoka Nakashima², Yukio Ago³, Ayami Sato⁴, Akihito Ishigami⁴, Norimitsu Morioka² (1. Sch. Pharmaceu. Sci., Hiroshima Univ., 2. Dept. Pharmacol., Grad. sch. Biomed. and Health Sci., Hiroshima Univ., 3. Dept. Cell. Mol. Pharmacol., Grad. sch. Biomed. and Health Sci., Hiroshima Univ., 4. Tokyo Metro. Inst. Gentol.)

[31P-am271S] Effects of intranasal administration of HMGB1 neutralizing antibody on anxiety/depressive-like behavior in mice with neuropathic pain

○Koji Tagami¹, Kazue Hisaoka Nakashima², Yoki Nakamura², Masahiro Nishibori³, Norimitsu Morioka² (1. Sch. Pharmaceu. Sci., Hiroshima Univ., 2. Grad. Sch. Biomed. and Health Sci., Hiroshima Univ., 3. Grad. Sch. Med, Dent. Pharm Sci., Okayama Univ.)

[31P-am272S] The nuclear receptor RORγ inhibitor alleviates mechanical hypersensitivity by suppressing microglial activity

○Nao Masuda¹, Maho Tsuruta¹, Yoki Nakamura², Kazue Hisaoka-Nakashima², Norimitsu Morioka² (1. Sch. Pharmaceu. Sci., Hiroshima Univ., 2. Grad. Sch. Biomed. and Health Sci., Hiroshima Univ.)

[31P-am273] Anti-inflammatory effect in the brain of ‘Ehime-kashi No. 48’ and narirutin

○Satoshi Okuyama^1,2, Toshiki Omasa¹, Daichi Takeda², Yoshiaki Amakura^1,3, Takehiro Kikuchi⁴, Shinsei Sasayama⁴, Hirona Nagai², Sayaka Ioki², Takeshi Komoda², Kana Nakamura², Takuma Wada², Atsushi Sawamoto^1,2, Takashi Uchikura³, Morio Yoshimura^1,3, Mitsunari Nakajima^1,2 (1. Grad. Sch. Clin. Pharm., Matsuyama Univ. , 2. Dept. Pharmacol., Matsuyama Univ., 3. Dept. Pharmacogn., Matsuyama Univ., 4. Ehime Res. Inst. Agric.)

[31P-am274S] Analysis of the effects of 3,5,6,7,8,3',4'-heptamethoxyflavone on a mouse model of LPS-induced chronic inflammation.

○Toshiki Omasa¹, Satoshi Okuyama¹, Atsushi Sawamoto¹, Mitsunari Nakajima¹ (1. Grad. Sch. Clin. Pharm., Matuyama Univ.)

[31P-am275S] Changes in expression of brain endothelial MCT1 contribute to glucocorticoid-induced abnormal behaviors

○Momoki Azuma¹, Ryo Ai¹, Kaede Ishihara¹, Saki Nishiura¹, Yuka Niizeki¹, Ayami Kita¹, Ryota Araki¹, Takeshi Yabe¹ (1. Fac. Pharmaceut. Sci., Setsunan Univ.)

[31P-am276S] Effect of Tomatidine on oxygen-glucose deprivation/reperfusion-induced microglial activation

○Yuka Kawade¹, Shion Tamura¹, Takuo Shimaoka¹, Haruyoshi Murakami¹, Ayami Kita¹, Ryota Araki¹, Takeshi Yabe¹ (1. Fac. Pharmaceut. Sci., Setsunan Univ.)

[31P-am277S] Involvement of astrocytes in the antidepressant action of Kir4.1 channel inhibitor quinacrine

○Ayana Kusaka¹, Yuto Ishizaki¹, Riho Inoue¹, Masaya Kusuno¹, Saki Shimizu¹, Yukihiro Ohno¹ (1. Fac. Pharmacy, Osaka Med. Pharm. Univ.)

[31P-am278S] Fluoxetine suppresses the persistent decline in sociability and morphological changes in hippocampal microglia following tumor resection in mice

○Takumu Yamasaki¹, Yusuke Onaka¹, Taro Yamaguchi¹, Masanori Yoneyama¹ (1. Setsunan University)

Withdrawn

[31P-am279] [Withdrawn]

[31P-am280] Microarray analysis of gene expression in the prefrontal cortex of rats subjected to pharmacological stress during early postnatal period.

○Taku Yamaguchi¹, Ryo Fukumori¹ (1. Nagasaki International University)

[31P-am281S] Single intraperitoneal administration of ferulic acid derivative FAD012 reduces blood-brain-barrier damage in rats with photothrombotic stroke.

○hiroshi sugouh¹, mayu noguti², nobuhiko yoshimatu², hirikazu matsuzaki¹, naohiro iwata¹, Meiyan Xuan¹, jun takayama¹, takeshi sakamoto¹, Bo Yuan¹, mari okazaki¹ (1. Grad. Sch. Pharm. Sci., Josai Univ., 2. Fac. Pharm. Sci., Josai Univ.)

[31P-am282] CUD 003, a synthetic derivative of curcumin, ameliorates scopolamine-induced memory impairment in rats.

○Hirokazu Matsuzaki¹, Sakuya Koyama¹, Shunnosuke Sato¹, Meiyan Xuan¹, Jun Takayama¹, Takeshi Sakamoto¹, Bo Yuan¹, Mari Okazaki¹ (1. Josai Univ. Pharmaceut. Sci.)

Withdrawn

[31P-am283] [Withdrawn]

[31P-am284S] Protective mechanism of ferulic acid derivative 012 against H2O2-induced necrotic death in RBMVEC

○Toshiya Aoyama¹, Meiyan Xuan¹, Jun Takayama¹, Takeshi Sakamoto¹, Hirokazu Matsuzaki¹, Bo Yuan¹, Mari Okazaki¹ (1. Grad. Sch. Pharm. Sci., Josai Univ.)

[31P-am285] Pathogenic role of NAMPT in the perivascular regions after cerebral ischemia in mice with type 2 diabetes

○Yui Iwatani¹, Haruna Yamamoto¹, Ruka Kinoshita¹, Mizuki Minamisawa¹, Hayato Minamikawa¹, Hideki Hayashi¹, Yoshiyuki Moriyama¹, Norio Takagi¹ (1. Tokyo Univ. Pharm. & Life Sci.)

[31P-am286S] Involvement of dorsal hippocampal immune activity in sex differences in fear extinction: CCL5-CCR5

○Ayano Yajima¹, Shingo Matsuda^1,2,3, Riho Takahashi¹, Kyoka Hidaka¹, Akihiro Mizutani¹ (1. Dept. Pharmacotherapeutics, Showa Pharm. Univ., 2. Dept. Cognitive Behavioral Physiology, Chiba Univ., 3. Dept. Ultrastructural Research, NCNP)

[31P-am287S] Sex-dependent effects of intraperitoneal and intraventral hippocampal administration of TrkB agonist on fear extinction

○Aili Takahashi¹, Shingo Matsuda^1,2,3, Yuuka Sumi¹, Yoshie Yoshida¹, Akihiro Mizutani¹ (1. Dept. Pharmacotherapeutics, Showa Pharm. Univ., 2. Dept. Cognitive Behavioral Physiology, Chiba Univ., 3. Dept. Ultrastructural Research, NCNP)

[31P-am288] Possibility of optic nerve regeneration by LOTUS in a model of optic nerve injury and analysis of visual function

○Mao Hiratsuka¹, ZHANG Peiyu, Toshiki Maeda², Aki Hashio¹, Kohtaro Takei⁴, Chieko Koike^2,3 (1. Col. Life Sci., Ritsumeikan Univ., 2. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 3. Center for Systems Vision Science, 4. Col. Sch. Medicine., Yokohama City Univ.)

[31P-am289S] Relationship between pH and lactate level in the brain of mice chronically treated with corticosterone.

○Yuka Niizeki¹, Moe Tomita¹, Ayami Kita¹, Ryota Araki¹, Takeshi Yabe¹ (1. Fac. Pharmaceut. Sci., Setsunan Univ.)

[31P-am290S] Changes of lactate level and pH in photothrombosis-induced infarction of the mouse cerebral cortex

○Chisato Tanaka¹, Yuka Niizeki¹, Ayami Kita¹, Ryota Araki¹, Takeshi Yabe¹ (1. Fac. Pharmaceut. Sci., Setsunan Univ.)

[31P-am291S] Effect of extracellular pH on β-catenin signaling cascade in cultured rat neural stem / progenitor cells

○Ryota Uemura¹, Tomoyuki Narusawa¹, Miku Tamura¹, Ayami Kita¹, Ryota Araki¹, Takeshi Yabe¹ (1. Fac. Pharmacent. Sci., Setsunan Univ.)

[31P-am292S] Changes in the expression of innate immunity-related receptors under the development of opioid tolerance

○Mutsumi Kamemoto¹, Yusuke Hamada^1,2, Yukari Suda^1,2, Naoko Kuzumaki^1,2, Minoru Narita^1,2 (1. Hoshi Univ., 2. Natl. Cancer Ctr. Res. Inst.)

[31P-am293S] Elucidation of the activation mechanism of amyloid-degrading enzyme neprilysin by a clinically used drug

○Ryusei Kusakabe¹, Nanami Tominaga¹, Momono Kawaguchi², Miku Sato², Sojyu Morishita², Kanna Hirobayashi², Masashi asai^1,2 (1. Grad. Sch. of Pharm. Sci., Yokohama Univ. of Pharm., 2. Fac. of Pharm. Sci., Yokohama Univ. of Pharm.)

[31P-am294S] Involvement of biased signal pathways in discriminative stimulus effects of Dopamine D₂ receptor agonists in rats

○Miku Hirata¹, Kensuke Yamashita¹, Suzuho Arima¹, Tomohisa Mori¹, Minoru Narita^1,2 (1. Hoshi Univ., 2. Natl. Cancer Ctr. Res. Inst.)

[31P-am295S] MDMA-like discriminative-stimulus effects of several prescribed drugs in rats : possible medications for Post Traumatic Stress Disorder

○May Onishi¹, Kensuke Yamashita¹, Hiroki Azuma¹, Tomohisa Mori¹, Minoru Narita^1,2 (1. Hoshi Univ., 2. Natl. Cancer Ctr. Res. Inst.)

[31P-am296] Mechanisms by which phenylephrine induces guinea pig aortic contractions: roles of α_1L-adreneroceptors and store-operated/voltage-dependent Ca²⁺ channels

○Keisuke Obara¹, Kento Yoshioka¹, Montserrat De Dios Regadera¹, Yusuke Matsuyama¹, Ayano Yashiro¹, Mayumi Miyokawa¹, Rumi Iura¹, Yoshio Tanaka¹ (1. Fac. Pharm. Sci., Toho Univ.)

[31P-am297S] Investigation of BDNF expression pathway in L6 rat skeletal myoblasts and involvement of estrogen.

○Shunsuke Shibusawa¹, Satoru Mitazaki¹, Sayori Nakabayashi¹, Mamoru Fukuchi¹ (1. Fac. of Pharm., Takasaki Univ. of Health and Welfare)

[31P-am298S] Serotonin-induced contractile mechanism in endothelium-denuded thoracic aortas from spontaneously hypertensive rats

○Minami Adachi¹, Miyu Kitamura¹, Ryusei Ito¹, Yuka Terada¹, Katsutoshi Yayama¹ (1. Fac. Pharm. Sci. Kobe Gakuin Univ.)

[31P-am299S] Protein expression of contractile signaling factors in thoracic aortas and superior mesenteric arteries from streptozotocin-induced diabetic rats

○Kana Hotta¹, Yuka Terada¹, Katsutoshi Yayama¹ (1. Fac. Pharm. Sci. Kobe Gakuin Univ.)

[31P-am300S] Angiotensin II-induced contractile mechanism in endothelium-denuded thoracic aortas and superior mesenteric arteries from spontaneously hypertensive rats

○Yui Fujisaki¹, Yuka Terada¹, Katsutoshi Yayama¹ (1. Fac. Pharm. Sci. Kobe Gakuin Univ.)

[31P-am301S] RhoA activation mechanism by serotonin in thoracic aortic smooth muscle cells from Wistar Kyoto rats and spontaneously hypertensive rats

○Miyu Kumagai¹, Yuka Terada¹, Katsutoshi Yayama¹ (1. Fac. Pharm. Sci. Kobe Gakuin Univ.)

[31P-am302] Change of the expression of endogenous calcitonin gene-related peptides in aristolochic acid induced nephropathy.

○Nene Kinjo¹, Yasuhisa Izushi¹, Yuichi Tasaka¹ (1. Sch. Pharm., Shujitsu Univ.)

[31P-am303S] The effect of N-acetylcysteine on CHAC1 expression in renal tubular cells during hypoxia/reoxygenation treatment.

○Haruka Matsuba¹, Yuki Saito¹, Yoshino Fujimura¹, Yoshitaka Kihira¹, Eiji Sato¹ (1. Fac. Pharm. Pharmaceut. Sci, Fukuyama Univ.)

[31P-am304] Lysophosphatidic acid induces the expression of MCP-1 via the LPA receptor 1 and the hypoxia-inducible factor in adipocytes.

○Honoka Uchikawa¹, Yosino Fuzimura¹, Yoshitaka Kihira¹, Eiji Sato¹ (1. Fukuyama Univ.)

[31P-am305S] Short-term effects of catheterization on detrusor muscle contraction in post-surgery overflow urinary incontinence rat model

○Ryoya Kawata¹, Yuji Hotta^1,2, Tomoya Kataoka³, Yoko Hibi², Yuya Ota², Takashi Hamakawa⁴, Yasue Kubota⁵, Takahiro Yasui², Kazunori Kimura^1,2 (1. Grad. Sch. Pharm. Sci., Nagoya City Univ., 2. Grad. Sch. Med. Sci., Nagoya City Univ., 3. Grad. Sch. Pharm., Chiba Inst. Sci., 4. Nagoya City Univ. West Med. Ctr., 5. Grad. Sch. Nurs., Nagoya City Univ.)

[31P-am307S] Role of progesterone receptor membrane component 1 (PGRMC1) in placental villi formation

○Atsuya Tsuru¹, Mikihiro Yoshie¹, Kazuhiro Morioka¹, Atsushi Shoji¹, Kazuya Kusama¹, Mana Azumi¹, Akio Yanagida¹, Kazuhiro Tamura¹ (1. Sch. Pharm., Tokyo Univ. Pharm. & Life Sci.)

[31P-am306] Role of Scavenger receptor class B type I in the progression of clear cell renal cell carcinoma

○Yukio Fujiwara¹, Hiromu Yano¹, Yoshihiro Komohara¹ (1. Grad. Sch. Pharm.Sci., Kumamoto Univ.)

[31P-am308S] Role of dihydroorotate dehydrogenase (DHODH) in cell fusion of placental trophoblast cells

○Kanoko Yoshida¹, Kazuya Kusama¹, Kei Yamazaki¹, Atsuya Tsuru¹, Mana Azumi¹, Mikihiro Yoshie¹, Junya Kojima², Masanori Ono², Hirotaka Nishi², Kazuhiro Tamura¹ (1. Sch. Pharm., Tokyo Univ. Pharm. & Life Sci., 2. Obstet.Gynecol., Tokyo Med. Univ.)

[31P-am309S] Involvement of AGN-1 that binds to protein phosphatase 6 in centrosome formation and cell cycle regulation

○Rina Oyama¹, Reina Kumazaki¹, Ryoji Kojima¹ (1. Lab. Anal. Pharmacol. Pharm. Meijo Univ.)

[31P-am310S] Effects of mechanical stimulation on inflammatory responses in primary cultured rat chondrocytes

○Yuka Tanaka¹, Hatsune Motonari², Yoki Nakamura², Kazue Hisaoka-Nakashima², Norimitsu Morioka² (1. Sch. Pharmaceu. Sci., Hiroshima Univ., 2. Grad. Sch. Biomed. Health Sci., Hiroshima Univ.)

[31P-am311S] Effects of liquiritigenin on IL-1β-induced IL-6 and matrix metalloproteases production in human synovial cells.

○Shinano Yamagishi¹, Hirokazu Suzuki^1,2, Takashi Kamei^1,2, Hisaaki Takahashi^1,2, Masakazu Miura^1,2, Yuri Matsuo¹, Masaaki Nomura¹, Tatsuo Takahashi^1,2 (1. Fac. Pharmac. Sci., Hokuriku Univ., 2. Hokuriku Univ. Healthy Aging Res. Grp.)

[31P-am312] The effects of Phellodendron bark extract, alone and in combination with Raloxifene, on bone loss of ovariectomized rats.

○Ryo Fukuyama¹, Moe Yamaguchi¹, Masakazu Nishihara², Ryohei Nishimoto², Sayaka Tanide², Nobuo Izumo³, Megumi Furukawa³, Ryoken Aoki³, Mitsugu Fujita¹ (1. Pharm. Sci., Hiroshima Int. Univ., 2. Nara Pref. Pharm. Research Center, 3. Yokohama University of Pharmacy)

[31P-am313] The role of HPGD in multidrug resistance in chronic myelogenous leukemia cell line K562/ADM

○Yoshihiko Shibayama¹ (1. Faculty of Pharm. Sci., Health Sciences University of Hokkaido)

[31P-am314] Carbidopa and benserazide suppress viability of both bortezomib-sensitive and -resistant multiple myeloma cells via inhibition of cystathionine-β-synthase, an H₂S-forming enzyme

○Fumiko Sekiguchi¹, Haruka Moriguchi¹, Yukiho Fukushima¹, Yuriko Iba¹, Tsukasa Hatakeyama¹, Maho Tsubota¹, Shiori Hiramoto¹, Takuya Okada², Naoki Toyooka², Hirokazu Tanaka³, Takashi Ashida³, Itaru Matsumura³, Atsufumi Kawabata¹ (1. Fac. Pharm., Kindai Univ., 2. Fac. Engineer., Univ. Toyama, 3. Fac. Med., Kindai Univ.)

[31P-am315] Effect of saffron water extract from Nobeoka on platelet aggregation and blood coagulation

○Chihiro Sugita¹, Kazuki Miya¹, Tatsuya Kai¹, Toshiyuki Atsumi¹, Hiroki Yoshida¹, Masahiko Kurokawa¹ (1. Grad. Sch. Clinical Pharm., Kyushu University of Health and Welfare.)

[31P-am316] Anti-melanogenic effect of Desmodesmus pannonicus hot-water extract.

○Kazuomi Sato^1,2, Yosuke Hiraga¹, Akiho Hasegawa², Setsuko Sakaki³, Yuji Yamaguchi³, Hiroyuki Takenaka³ (1. Grad. Sch. of Agri., Tamagawa Univ., 2. Col. Agri., Tamagawa Univ., 3. Microalgae Corp.)

[31P-am317] Effect of residual chlorine in tap water on hydrophobicity of hair surface

○Ai Fukumura¹, Takeyuki Yamamoto¹, Hirohito Nakajima¹ (1. LIXIL)

[31P-am318S] Discovery of cosmetic constituents derived from cherry bark showing inhibitory effects on the degradation of dermal components.

○Kayo Kishimoto¹, Atsushi Kato¹ (1. Department of Hospital Pharmacy, University of Toyama)

[31P-am319S] Isolation of active components from daidai (Citrus aurantium) for cosmetic applications.

○Takato Iwaizumi¹, Ayumi Kondo¹, Sara Nakagawa¹, Atsushi Kato¹ (1. Department of Hospital Pharmacy, University of Toyama)

[31P-am320] Inhibition of hair growth by lipid hydroperoxide and suggestions for improvement

○Yuji Tani¹, Naoki Umetsu¹, Ryosuke Shinomiya¹, Takun Furukawa¹, Shiro Makihara¹, Akinari Abe¹, Akihisa Morito¹ (1. Taisho Pharmaceutical Co., Ltd.)

[31P-am321] What is the effect of age-related MITOL decrease on skin aging?

○Midori Tanaka¹, Yuki Inokuchi¹, Nobuyuki Takeuchi¹, Akihisa Morito¹ (1. Taisho Pharmaceutical Co., Ltd.)

[31P-am322] The effects of heparinoid on improving skin barrier function by producing protein-bound ceramide

○Ayaka Otsuka¹, Fuminari Akiyama¹, Yuki Inokuchi¹, Nobuyuki Takeuchi¹, Akihisa Morito¹ (1. Taisho Pharmaceutical Co., Ltd.)

[31P-am323] Effect of Glyceryl Glucoside produced by chemical synthesis on moisturizing function of skin

○Chifumi Shinagawa¹ (1. Gun Ei Chemical Industry)

[31P-am324] Lens specific promoter casette in mouse

○Eri Shono¹, Yudai Endo¹, Yui Inomata¹, Atsushi Sanbe¹ (1. Sci. of Pharm. Iwate Medical University)

[31P-am325] Effect of 5’-CMP (5'-cytidylate) upon phospholipid production of epidermis

○Kazuya Ishige¹ (1. Biochemicals Division, YAMASA Corporation)

[31P-am326] Effect of intermittent fasting on retinal neurodegeneration in a mouse model of diabetes

○Yuki Ishimaru¹, Daiki Yoneshima¹, Mikiya Yoshida¹, Miku Nishimura¹, Yasuhiro Yoshioka¹ (1. Lab. Pharmacotherap., Fac. Pharmaceut. Sci., Setsunan Univ.)

[31P-am327] Transcriptome analysis of sweat secretion mechanism by PACAP with PAC1R KO mice

○Yamashita Michio¹, Junko Shibato², Randeep Rakwal³, Takahiro Hirabayashi², Yoshihiko Chiba¹, Seiji Shioda⁴, Fumiko Takenoya¹ (1. Fac. Pharm., Hoshi Univ., 2. Shonan Univ. of Med. Sci., 3. Fac. Health and Sport Sci., Univ. of Tsukuba , 4. Fac. Pharm. Sci., Shonan Univ. of Med. Sci.)

[31P-am328] Keratide, a peptide derived from waterfowl feather keratin, contributes to the protection of epidermal keratinocytes.

Koyo Amano², Saki Ohta¹, Hinata Nanami¹, ○Hideki Inoue^1,2, Yuri Hosaka³ (1. Dept. of Appl. Biosci., Kanagawa Inst. Tech., 2. Grad. Biosci., Kanagawa Inst. Tech., 3. Keratin Proj., TOYO Feather Industry Co., Ltd)

[31P-am329] Analysis of alteration in circadian rhythms by replicative senescence and miRNA in human skin cells

○Miwa Sasaoka¹, Nono Yamamura¹, Kenta Shingaki¹ (1. Noevir Co., Ltd.)

Session information

[31P-am] Pharmacology 5

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