[3P1071(4T18-09)] CD74-NRG1, a fusion gene product, leads to ErbB-NFĸB-IGF2 autocrine/paracrine circuit and confers cancer stem cell properties

〇Takahiko Murayama^1,2,3, Takashi Nakaoku⁴, Masato Enari⁵, Tatsunori Nishimura¹, Kana Tominaga³, Asuka Nakata¹, Arinobu Tojo³, Sumio Sugano², Takashi Kohno⁴, Gotoh Noriko^1,3 (1.Div. Cancer Cell Biol., Cancer Res. Inst. Kanazawa Univ., 2.Lab. Functional Genomics, Grad. Sch. Frontier Sci., Univ. Tokyo, 3.Div. Mol. Therapy, IMS, Univ. Tokyo, 4.Div. Genome Biol., Natl. Cancer Ctr. Res. Inst., 5.Div. Refractory Cancer Res., Natl. Cancer Ctr. Res. Inst.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1072(4T18-10)] TGF-β2-TGFBR3 signal is a key regulator of cancer-initiating cell maintenance in clear cell renal cell carcinoma

〇Jun Nishida¹, Shogo Ehata¹, Kohei Miyazono¹ (1.Dept. of Mol. Pathol., Grad. Sch. of Med., Univ. of Tokyo)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1073(4T18-11)] Senescence derived from glioma stem cell differentiation and its implication in the tumor progression

〇Rie Ouchi^1,2, Sachiko Okabe¹, Toshiro Migita¹, Ichiro Nakano³, Hiroyuki Seimiya^1,2 (1.Div. Mol. Biother., Cancer Chemother. Ctr., JFCR, 2.Grad. Sch. Frontier Sci., Univ. Tokyo, 3.Dept. Neurol. Surg., Ohio State Univ., USA)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1074(4T18-12)] Glim enhance the formation and development of gliomas in mouse and human

〇Naoki Ohtsu¹, Yuka Nakatani², Daisuke Yamashita³, Takanori Ohnishi³, Toru Kondo^1,4 (1.Dept. of Stem Cell Biology、IGM Hokkaqido Univ., 2.RIKEN, CLST, 3.Dept. of Neurosurg., Med., Ehime Univ., 4.RIKEN, CDB)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1075(4T18-13)] Arhgef5 is upregulated during TGF-β-induced epithelial-mesenchymal transition and promotes tumor progression

〇Yu Komiya¹, Suguru Nomimura¹, Yasuhito Onodera³, Miho Kuroiwa¹, Shigeyuki Nada², Masato Okada² (1.Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Osaka, 2.Dept. of Onc. Res., RIMD, Univ. of Osaka, 3.Dept. of Mol. Biol., Grad. Sch. of medicine., Univ. of Hokkaido)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1076(4T18-14)] Molecular mechanism of epithelial-mesenchymal transition induced by LEF-1 lacking its β-catenin binding domain

〇Wakako Kobayashi¹, Masayuki Ozawa¹ (1.Dept. Biochem and Mol. Biol., Grad. Sch. Med. Dent. Sci., Univ. of Kagoshima)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1077(4T18-15)] Downregulations of ETS factors, ERG and FLI1, in endothelial cells causes endothelial-to-mesenchymal transition

〇Nao Nagai^1,2,3, Ryo Nakaki⁴, Yasuharu Kanki⁵, Yoshihiro Matsumura⁶, Juro Sakai⁶, Hiroyuki Aburatani⁴, Takashi Minami^1,2 (1.Div. of Vascular Biol., RCAST, The Univ. of Tokyo, 2.IRDA, Kumamoto Univ., 3.Lab. of Mol. Biol., Grad. Sch. of Pharm. Sci., The Univ. of Tokyo, 4.Genome Sci. Div., RCAST, The Univ. of Tokyo, 5.Radioisotope Ctr., The Univ. of Tokyo, 6.Div. of Metabolic Med., RCAST, The Univ. of Tokyo)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1078(4T18L-01)] Lats1 phosphorylates ZEB1 and regulates EMT-MET in breast cancer cells

〇Satomi Mukai¹, Yumi Ando¹, Yorika Kato¹, Kosuke Torigata¹, Norikazu Yabuta¹, Hiroshi Nojima¹ (1.Dept. of Mol. Genet., R.I.M.D., Univ. of Osaka)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1079(4T18L-02)] Functional role of extracellular vesicles in scirrhous type gastric cancer microenvironment.

〇Yutaka Naito¹, Masakazu Yashiro², Kosei Hirakawa², Wataru Yasui³, Takahiro Ochiya¹ (1.Div. Mol. Cell. Med., Natl. Cancer Ctr. Res. Inst., 2.Dept. Surg. Oncol., Osaka City Univ. Grad. Sch. of Med., 3.Dept. Mol. Pathol., Inst. Biomed. & Health Sci., Hiroshima Univ. Grad. Sch.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1080(4T18L-03)] Suppression of breast cancer metastasis by inhibition of exosomes

〇Nao Aoki¹, Naoomi Tominaga¹, Fumitaka Takeshita¹, Hikaru Sonoda², Takahiro Ochiya¹ (1.Div. Mol. & Cell. Med., Natl. Cancer Ctr., Res. Inst., 2.Shionogi & Co., Ltd)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM