[3P1233(4T15L-03)] RNA and nucleolar localization prevents toxicity and aggregation of carboxyl-terminal fragment of ALS-linked TDP43 via inhibition of the structural transition in Prion-like domain.

〇Akira Kitamura^1,2, Yusaku Nakayama², Ai Shibasaki², Ayami Taki², Sachiko Yuno², Masataka Kinjo^1,2 (1.Lab. of Mol. Cell Dyn., Fac. Adv. Life Sci., Hokkaido Univ., 2.Grad. Sch. of Life Sci., Hokkaido Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1234(4T15L-04)] TDP-43 Binds and Transports G-Quadruplex-Containing mRNAs into Neurites for Local Translation

〇Akira Ishiguro¹, Akira Ishihama¹, Nobuyuki Kimura² (1.Research Center for micro-nano tec., Univ. of Hosei, 2.Dept. of AD, Cent. for Dev. of Adv. Med. for Dementia, NCGG)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1235(4T15L-05)] TDP-43 transports mRNA of ribosomal proteins

〇Seiichi Nagano¹, Sachiko Hirokawa², Masatoyo Nishizawa³, Kenji Sakimura⁴, Osamu Onodera², Toshiyuki Araki¹ (1.Dept. of PNS Res., Natl. Inst. of Neurosci., NCNP, 2.Dept. of Mol. Neurosci., Brain Res. Inst., Niigata Univ., 3.Dept. of Neurol., Brain Res. Inst., Niigata Univ., 4.Dept. of Cell. Neurobiol., Brain Res. Inst., Niigata Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1236(4T15L-06)] Selective deprivation of the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer' disease model without affecting senile plaque deposition

〇Izuo Naotaka¹, Kazuma Murakami², Masahiro Maeda³, Toshiaki Kume⁴, Koutaro Yokote¹, Kazuhiro Irie², Takahiko Shimizu¹ (1.Grad. Sch. Med., Chiba Univ., 2.Grad. Sch. Agri., Kyoto Univ., 3.Immuno-Biological Laboratories, 4.Grad. Sch. Pharm., Kyoto Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1237(4T15L-07)] Regulation of an Aβ-degrading enzyme activity by genes on chromosome 21

〇Masashi Asai^1,2, Takashi Kawakubo¹, Ryotaro Mori¹, Aimi Kinjo², Shoko Kimura², Shifu Takashima², Keiro Shirotani^1,2, Nobuhisa Iwata^1,2 (1.Dept. of Genome-based Drug Discov., Grad. Sch. of Biomed. Sci., Nagasaki Univ., 2.Dept. of Genome-based Drug Discov., Sch. of Pharm. Sci., Nagasaki Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1238(4T15L-08)] UBE3A regulates global protein turnover by negatively controlling the ubiquitin-proteasome pathway

〇Hiroshi Kokubu¹, Janghoo Lim¹ (1.Dept. of Genetics, Yale University School of medicine)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1239(4T特p-06)] Structural abnormalities of the nodes of Ranvier is associated with the onset of major depressive disorder

〇Shingo Miyata¹, Shoko Shimizu¹, Takashi Tanaka¹, Akiyo Matsumura¹, Ayumi Kawakami¹, Mieko Kashima¹, Masaya Tohyama^1,2 (1.Div Mol Brain Sci, Res Ins Tra Asian Med, Kindai Univ, 2.Osaka Pref Hosp Org)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1240(4T特p-07)] Effects of missense mutations associated with autism spectrum disorder on the processing and function of synaptic adhesion molecule Neuroligin 4X

〇Takafumi Yumoto¹, Yousuke Nao¹, Misaki Kimura¹, Taisuke Tomita¹ (1. Dept. of Neuropathology and Neuroscience, Univ. of Tokyo)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1241(4T特p-08)] Double mutation of Six4 and Six5 facilitates skeletal muscle regeneration and expands life span of mdx mice

〇Kiyoshi Kawakami¹, Hiroshi Yajima¹ (1.Div. Biology, Cent. for Mol. Med., Jichi Med. Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1242(4T特p-09)] RNA splicing regulated by USP15 is involved in neuromuscular functions

Jaehyun Kim¹, 〇Fuminori Tsuruta¹, Tomoki Chiba¹ (1.Grad. Sch. of Life and Env. Sci., Univ. of Tsukuba)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM