[P-795] Involvement of GLP-1 secretion in diarrheal induced by metformin, a drug for Type II diabetes

^○Momoka Mizoguchi¹, Saho Furukawa¹, Hiroshi Takemori¹, Masafumi Ito², Mutsumi Asai², Hirofumi Morino², Takanori Miura², Takashi Shibata² (1.Graduate School of Natural Science and Technology,Gifu University, 2.Taiko Pharmaceutical Co., Ltd)

The 94th Annual Meeting of JBS

[P-796] Defects in mitochondrial quality control induces impaired insulin secretion in pancreatic beta-cells.

^○Kyota Aoyagi¹, Shun-ichi Yamashita², Chiyono Nishiwaki¹, Yoko Nakamichi¹, Yoshihiro Akimoto³, Tomotake Kanki², Mica Ohara-Imaizumi¹ (1.Department of Cellular Biochemistry, Kyorin University School of Medicine, 2.Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences, 3.Department of Microscopic Anatomy, Kyorin University School of Medicine)

The 94th Annual Meeting of JBS

[P-797] Imaging of amylin aggregation using quantum-dot nanoprobes

^○Ziwei Liu, Keiya Shimamori, Masahiro Kuragano, Kiyotaka Tokuraku (Division of Sustainable and Environmental Engineering, Muroran Institute of Technology)

The 94th Annual Meeting of JBS

[P-798] Hepatoprotective effect of taxifolin in a mouse model of nonalcoholic steatohepatitis

^○Bin Fu¹, Miyako Tanaka¹, Michiko Itoh^2,3, Takayuki Inoue⁴, Noriko Satoh-Asahara^2,4, Takayoshi Suganami¹ (1.Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, 2.Department of Metabolic Syndrome and Nutritional Science, Research Institute of Environmental Medicine, Nagoya University, 3.Kanagawa Institute of Industrial Science and Technology, 4.Department of Endocrinology, Metabolism and Hypertension Research, Clinical Research Institute, National Hospital Organization, Kyoto Medical Center)

The 94th Annual Meeting of JBS

[P-799(2T14e-03)] Impaired glucose-stimulated insulin secretion due to mitochondrial abnormalities in pancreatic beta-cells of 5-aminolevulinate synthase1 (ALAS1) gene knockout heterozygous mice

^○Kazuya Takeda^1,2, Koen van Wijk¹, Tomohiro Kimura¹, Satoshi Okano¹, Sinichi Saitho¹, Hiroaki Yamaguchi², Kodama Ken³, Takahashi Kiwamu⁴, Toru Tanaka⁴, Motoo Nakazima⁴, Osamu Nakazima¹ (1.Inst. for Promotion of Med.Sci. Res., Yamagata Univ. Sch. Med., 2.Dep. of Pharmacy, Yamagata Univ. Sch. Med., 3.Neopharm Japan Co., Ltd., 4.SBI Pharmaceuticals Co., Ltd.)

The 94th Annual Meeting of JBS

[P-800(1T14e-11)] The SGLT2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model

^○Naoki Yoshioka^1,2, Miyako Tanaka¹, Kozue Ochi¹, Akiko Watanabe¹, Michiko Itoh^3,4, Masatoshi Ishigami², Mitsuhiro Fujishiro², Takayoshi Suganami¹ (1.Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, 2.Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 3.Kanagawa Institute of Industrial Science and Technology, 4.Department of Metabolic Syndrome and Nutritional Science, Research Institute of Environmental Medicine, Nagoya University)

The 94th Annual Meeting of JBS

[P-801] Adult murine pancreatic &beta-cells retain repetitive proliferation capacity in a diphtheria toxin mediated &beta-cell ablation model

^○Xue Chen¹, XiLin Zhang¹, Ryo Hatano¹, Yujie Ma¹, Atsushi Kaneda², EunYoung Lee¹, Takashi Miki¹ (1.Department of Medical Physiology, Graduate School of Medicine Chiba University, 2.Department of Molecular Oncology, Graduate School of Medicine, Chiba University,)

The 94th Annual Meeting of JBS

[P-802] Overexpression of type 2 diabetes mellitus susceptibility gene "ZFAND3" in the liver improves hepatic insulin resistance

^○Kahori Shimizu¹, Yuya Ogiya¹, Shotaro Michinaga², Kaede Yoshinaga¹, Hajime Kimura¹, Tomoyuki Terada¹, Fuminori Sakurai³, Mizuguchi Hiroyuki^3,4,5,6, Koji Tomita¹, Toru Nishinaka¹ (1.Pharma., Osaka Ohtani Univ., 2.Meiji Pharm. Univ., 3.Grad. Sch. of Pharma. Sci., Osaka Univ., 4.Natl. Inst. of Biomed. Innov. Health Nutr., 5.MEIC, Osaka Univ., 6.OTRI, Osaka Univ.)

The 94th Annual Meeting of JBS

[P-803(2T14e-07)] Examination of the significance of B2 adrenergic receptor in the pathogenesis of non-alcoholic steatohepatitis

^○Shinichiro Kimura^1,2, Miyako Tanaka¹, Hirohito Kuwata^1,3, Michiko Itoh^4,5, Yoshihiro Ogawa², Takayoshi Suganami¹ (1.Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, 2.Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3.Department of Diabetes and Endocrine Medicine, Nara Medical University, Kashihara, 4.Research Institute of Environmental Medicine, Nagoya University, 5.Kanagawa Institute of Industrial Science and Technology, Ebina, Japan.)

The 94th Annual Meeting of JBS

[P-804] Differential effects of excess HFCS on the hippocampal neurotrophic factor in childhood or adulthood

^○Itsuki Kageyama¹, Eiji Munetsuna², Hiroya Yamada³, Mirai Yamazaki⁴, Yoshitaka Ando¹, Genki Mizuno¹, Yuki Nouchi¹, Atsushi Teshigawara¹, Takuya Wakasugi¹, Tomohide Sakakibara¹, Hiroaki Ishikawa¹, Koji Suzuki¹, Koji Ohashi¹ (1.Fujita Health University Graduate School of Health Sciences, 2.Department of Biochemistry, Fujita Health University School of Medicine, 3.Department of Hygiene, Fujita Health University School of Medicine, 4.Department of Medical Technology, Kagawa Prefectural University of Health Sciences)

The 94th Annual Meeting of JBS