[2P-495] Restoration of Anti-Cancer Drug Sensitivity by FGFR3IIIc Signaling Inhibitors Using Colorectal Cancer Organoids.

^〇Moe Nakamoto¹, Kazuki Fukumitsu¹, Yudai Miyoshi², Nobuhiro Ueno², Yoshihisa Okuchi³, Shugo Ueda³, Misuzu Seo^1,2 (1.Kyoto Sangyo University Graduate School of Life Sciences, 2.Kyoto Sangyo University Faculty of Life Sciences, 3.Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-496] C9orf10/Ossa regulates bone metastasis of established lung adenocarcinoma sub-line H322L-BO4 cells in mouse model.

^〇Takamasa Uekita¹, Reiko Yagi², Tohru Ichimura¹, Ryuichi Sakai³ (1.Department of Applied Chemistry, National Defense Academy, 2.Division of Metastasis and Invasion Signaling, National Cancer Center Research Institute, 3.Division of Biochemistry, Kitasato University School of Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-497] Challenges in Establishing Patient-Derived Tumor Organoids as a Platform for the Screening of Therapeutic RNAs

Ri Sho¹, ^〇Xuhong Zhang², Jun Suzuki³, Hikaru Watanabe³, Satoshi Shiono³, Kuniaki Chida⁴, Tsukasa Ito⁴, Masayoshi Souri¹, Tsuneo Konta¹ (1.Dept. of Pub. Health & Hygiene, Yamagata Univ. Grad. Sch. of Med. Sci., 2.Dept. of Biochem. & Mol Biol., Yamagata Univ. Grad. Sch. of Med. Sci., 3.Dept. of Surg. II, Yamagata Univ. Sch. of Med., 4.Dept. of Otolaryngology, Head & Neck Surg., Yamagata Univ. Sch. of Med.)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-498(1T14a-08)] Regulatory mechanism for PROTAC-induced degradation of cancer-related protein

^〇Rikuto Honda^1,2, Fumiaki Ohtake^1,2 (1.Institute for Advanced Life Sciences, Hoshi University, 2.School of Pharmaceutical Sciences, Hoshi University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-499] Examination of the effects of food-derived resident bacteria on a mouse model of colorectal cancer.

^〇Kurumi Taniguchi¹, Yuka Ikeda², Sayuri Yoshikawa¹, Haruka Sawamura¹, Satoru Matsuda^1,2,3 (1.Department of Food Science and Nutrition Graduate School of Humanities and Sciences Nara Women's University, 2.Department of Human Life and Environmental Sciences Graduate School of Humanities and Sciences Nara Women's University, 3.Department of Food Science and Nutrition Faculty of Human Life and Environment Nara Women's University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-500] Development of preventive agents for familial adenomatosis polyposis via splicing regulation

^〇Hiroko Kobayashi¹, Masahiko Ajiro², Tomonari Awaya^1,3, Masatoshi Hagiwara¹ (1.Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, 2.Division of Cancer RNA Research, National Cancer Center Research Institute, 3.Laboratory of Tumor Microenvironment and Immunity, Graduate School of Medicine, Kyoto University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-501] Squamous cell carcinoma-derived G-CSF promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients

Kohei Kemuriyama^1,2,3, Jianbo An², Tomokazu Yamaguchi¹, Satoru Motoyama³, Yushi Nagaki³, Yusuke Sato³, Yoshihiro Minamiya³, ^〇Keiji Kuba¹ (1.Department of Pharmacology, Kyushu University Graduate School of Medical Sciences, 2.Department of Biochemistry, Akita University Graduate School of Medicine, 3.Department of Biochemistry, Akita University Graduate School of Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-502] Analysis of the recognition mechanism of transformed cells by tissue-resident macrophages

^〇Shunya Tanabe¹, Mihoko Kajita¹, Kazuki Motomura¹, Toshiaki Ohteki², Kyoko Sirakabe¹ (1.Ritsumeikan University Graduate School of Life Sciences, 2.Medical Research Institute Tokyo Medical and Dental University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-503(1T14a-09)] Differentiation and early tumorigenesis mechanisms verified from novel cell lines of cancer stem-like cells

^〇Yusuke Ohta¹, Wakana Takeuchi², Shiori Yanai², Kyosuke Kuroda², Takao Nomura^1,2, Katsumi Maenaka^1,2 (1.Grad. Sch. Pharm. Sci., Hokkaido Univ., 2.Grad. Sch. Life. Sci., Hokkaido Univ.)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-504] The somatic mutation in the mitochondrial gene detected in breast cancer tissue alters a metabolic pathway

^〇Kenji Watanabe¹, Shigeru Yamamoto², Noriko Maeda², Naruyo Nishimura¹, Keishiro Isayama³, Mikako Yagi⁵, Dongchon Kang⁴, Masaaki Oka², Hiroaki Nagano², Yoichi Mizukami¹ (1.Institute of Gene Research, Science Research Center, Univ. of Yamaguchi, 2.Department of Digestive Surgery and Surgical Oncology, Grad. Sch. of Med., Univ. of Yamaguchi, 3.Institute of Life Science, Science Research Center, Univ. of Yamaguchi, 4.Department of Clinical Chemistry and Laboratory Medicine, Grad. Sch. of Med. Sci., Univ. of Kyushu, 5.Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University)

The 96th Annual Meeting of the Japanese Biochemical Society