[1AW-10-3] Nuclear rupture in a mouse model of LMNA-related cardiomyopathy causes cytoplasmic exposure of the proinflammatory signaling protein HMGB1

^○Kohta Ikegami^{1, 2, 3}, Alexis Stutzman³, Sachie Ikegami³, Omar Almakki³, Sunny Liu³, Ozanna BurnickaTurek³, Peter Pytel⁴, Ivan Moskowitz^{3, 5, 4} (1.Div of Mol Cardiovas Bio, Cincinnati Children's Hospital Med Ctr, 2.Dept of Pediatrics, Univ of Cincinnati, 3.Dept of Pediatrics, Univ of Chicago, 4.Dept of Pathology, Univ of Chicago, 5.Dept of Human Genet, Univ of Chicago)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 9:40 AM - 9:58 AM

[1AW-10-4] Chromatin structural alteration induced by oncovirus infection aberrantly activate transcriptional regulation

^○Atsushi Okabe¹, Kie Kyon Huang², Keisuke Matsusaka¹, Masaki Fukuyo¹, Takayuki Hoshii¹, Bahityar Rahmutulla¹, Genki Usui^{1, 3}, Teru Kanda⁴, Tetsuo Ushiku³, Masashi Fukayama³, Patrick Tan², Atsushi Kaneda¹ (1.Dept. of Mol. Oncol., Grad. Sch. of Med., Chiba Univ., 2.Cancer and Stem Cell Biol. Prog., Duke-NUS Med. Sch., 3.Dept. of Pathol., Grad. Sch. of Med., The Univ. of Tokyo, 4.Div. of Microbio., Facul. of Med., Tohoku Med. and Pharm. Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 9:58 AM - 10:16 AM

[1AW-10-5] Identification of a histone reader involved in the memory system of stem cell epigenome

^○Naoko Hattori¹, Yuyu Liu¹, Kana Kimura¹, Miho Koizumi², Hiroaki Honda², Toshikazu Ushijima¹ (1.Division of Epigenomics, National Cancer Center Research Institute, 2.Institute of Laboratory Animals, Tokyo Women's Medical University)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 10:16 AM - 10:34 AM

[1AW-10-6] In vivo reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

^○Jumpei Taguchi, Yasuhiro Yamada (Div. of Stem Cell Pathol., IMSUT, Univ. of Tokyo)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 10:34 AM - 10:52 AM

[1AW-10-7] Coordination of FGF and Wnt in the construction of the hierarchical branching structure of lung

^○Hisako TakigawaImamura, Takashi Miura (Grad. Sch. of Med. Sci., Kyuryu Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 10:52 AM - 11:10 AM

[1AW-11-1] Comprehensive understanding of the molecular mechanisms of cell cycle arrest caused by splicing inhibition

^○Daisuke Kaida (School of Med., Univ. of Toyama)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 9:00 AM - 9:18 AM

[1AW-11-2] Controlling RNA splicing with small molecules

^○Kazunori Koide (University of Pittsburgh)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 9:18 AM - 9:36 AM

[1AW-11-3] Precision Medicine to Provide Resistance to SARS-CoV-2 Infection by Switching OAS1 Splicing Isoforms

^○Kei IIDA¹, Masahiko Ajiro¹, Yukiko Muramoto^{2, 3}, Toru Takenaga^{2, 3}, Masatsugu Denawa¹, Ryo Kurosawa¹, Takeshi Noda^{2, 3}, Masatoshi Hagiwara¹ (1.Grad. Sch. of Med., Kyoto University, 2.Institute for Frontier Life and Medical Sciences, Kyoto University, 3.CREST, Japan Science and Technology Agency)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 9:36 AM - 9:51 AM

[1AW-11-4] Pharmacological systems analysis defines CLK and EIF4A3 mRNA processing functions

^○Shinsuke Araki (Research, Takeda Pharmaceutical Company)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 9:51 AM - 10:09 AM

[1AW-11-5] Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia

^○Masahiko Ajiro¹, Kei Iida¹, Tomonari Awaya¹, Krainer Adrian², Masatoshi Hagiwara¹ (1.Kyoto Univ. Grad. Sch. of Med., 2.Cold Spring Harbor Lab.)

The 44th Annual Meeting of the Molecular Biology Society of Japan |Wed. Dec 1, 2021 10:09 AM - 10:27 AM