[3P-0537] Exploiting cancer-associated vulnerabilities of mitochondrial BIG3-PHB2 axis in clinical therapeutics for triple negative breast cancer

^○Hitoshi Aihara¹, Tetsuro Yoshimaru¹, Masaya Ono², Mitsunori Sasa³, Yasuo Miyoshi⁴, Toyomasa Katagiri¹ (1.Div. Genome Med., Inst. Advanced Med. Sci., Tokushima Univ., 2.Div. Chemother. Clin. Res., Natl Cancer Ctr. Res. Inst., 3.Dept. Surg., Tokushima Breast Care Clinic, 4.Dept. Surg., Div. Breast Endocrine Surg., Hyogo College of Med.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0538] Genomic Destabilization-Associated Risks, i.e., Resistance Acquisition and Cellular Migration, Arisen with Therapeutic Treatments, are Suppressible with Olaparib

^○Mafuka Suzuki^{1, 2}, Haruka Fujimori^{1, 2}, Kakeru Wakatsuki¹, Mai Hyodo^{1, 2}, Yusuke Matsuno¹, Rika Matsuo¹, Mitsunori Shiroishi², Kenichi Yoshioka¹ (1.Lab. of Genome stability Maintenance, Natl. Cancer Ctr. Res. Inst., 2.Dept. of Biol. Sci. and Technol., Tokyo Univ. of Sci.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0539] Analysis of characteristics and induction mechanisms of Glioblastoma stem cell with hydrogels

^○Kyosuke Fujishima¹, Masumi Tsuda^{2, 3}, Kosei Nakamura¹, Yuuki Terasima¹, lei Wang^{2, 3}, Jian Ping Gong^{3, 4}, Shinya Tanaka^{2, 3} (1.Sch. of Med. 5th Grade, Hokkaido Univ., 2.Dep. of Cancer Pathol., Faculty of Med., Hokkaido Univ., 3.WPI-ICReDD, Hokkaido Univ., 4.Lab. of Soft and Wet Matter, Faculty of Adv. Life Science, Hokkaido Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0540] Loss of DDX41 function induces RNA splicing disability that results in R-loop-associated DNA damage

^○Mayumi Hirayama^{1, 2}, Satoru Shinriki¹, Hideki Nakayama², Hirotaka Matsui¹ (1.Dept. of Lab. Med., Fac. Life Sci., Kumamoto Univ., 2.Dept. of Oral Surg., Fac. Life Sci., Kumamoto Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0541] A novel intragenic enhancer regulates TGF-β-induced SRC expression.

^○Soshi Noshita^{1, 2}, Yuki Kubo^{1, 2}, Hiroki Nishida^{3, 2}, Daisuke Okuzaki², Masato Okada² (1.Dept. of Biol., Grad. Sch. of Sci., Osaka Univ., 2.Dept. Onc. Res., RIMD, Osaka Univ., 3.Dept. of Med., Osaka Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0542] Investigation of role of KPNA7 for proliferation in glioblastoma cells

^○Takahiro Yamauchi^{1, 2}, Hirotaka Nomiya², Masami Yamada², Kenichiro Kikuta¹ (1.Dept. of Neurosurg., Univ. of Fukui, 2.Dept. of Biochem., Univ. of Fukui)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0543] Essential Role of activated BCAA metabolism in chondrosarcoma

^○Yoshiki Yamamoto¹, Makoto Nakagawa^{2, 3}, John Glushka⁴, Arthur Edison⁴, Fumihiko Nakatani⁵, Takahiro Ito¹, Ayuna Hattori¹ (1.Inst. for Frontier Life and Med. Sci., Kyoto Univ., 2.Dept. of Orthopaedic Surg., Grad. Sch. of Med. Sci., Kyushu Univ., 3.Dept. of Orthopaedic Surg., Duke Univ., 4.Complex Carbohydrate Res. Ctr., UGA, 5.Dept. of Musculoskeletal Oncology and Rehabilitation, NCCHC)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0544] Catechol-O-methyltransferase (COMT) suppresses invasion potential through the regulations of central metabolism in ovarian cancer cells

^○Yuyu Yamaguchi, Masaru Tomita, Tomoyoshi Soga, Shojiro Kitajima (Inst. for Adv. Biosci., Keio Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0545] Investigation of Cancer Reclassification by the HIF1 downstream genes.

^○Kazuya Nakamichi¹, Jun Nakayama², Kentaro Semba^{1, 3} (1.Dept. Life Sci. & Med. Biosci., Waseda Univ., 2.Div. Cell. Signaling, Natl. Cancer Ctr. Res. Inst., 3.TR Ctr., Fukushima Med Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan

[3P-0546] Analysis of signaling pathways regulating stem cell marker expression in glioblastoma using hydrogels

^○Kosei Nakamura¹, Masumi Tsuda^{2, 3}, Yuki Terashima¹, Kyosuke Fujishima¹, Lei Wang^{2, 3}, Jian Ping Gong^{3, 4}, Shinya Tanaka^{2, 3} (1.Sch. of Med., Hokkaido Univ., 2.Dep. of Cancer Pathol., Faculty of Med., Hokkaido Univ., 3.WPI-ICReDD, Hokkaido Univ.,, 4.Lab. of Soft and Wet Matter, Faculty of Adv. Life Science, Hokkaido Univ.)

The 44th Annual Meeting of the Molecular Biology Society of Japan