[2P-635] Development of a novel screening system for melanogenesis and its application to explore drugs for vitiligo vulgaris

^〇Waka Shimosako¹, Susumu Tanimura¹, Hiroyuki Murota², Kohsuke Takeda¹ (1.Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University, 2.Dermatology, Graduate School of Biomedical Sciences, Nagasaki University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-636] Molecularly linked antibodies inhibit the function of metal-binding proteins

^〇Risa Asano¹, Makoto Nakakido¹, Miyu Takeuchi¹, Chihiro Aikawa², Ichiro Nakagawa², Kohei Tsumoto^1,3,4 (1.Dept of Bioeng.Eng.,The Univ. of Tokyo, 2.Dept. of Microbiol., Sch. of Med., Univ. of Kyoto , 3.Dept. of Chem. Biotech., Sch. of Eng., Univ. of Tokyo, 4.Inst. of Med. Sci., Univ. of Tokyo)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-637] Binding activity and denaturant resistance analysis of immobilized single-domain antibodies

^〇Atsunori Hirao¹, Satoru Nagatoishi^1,2, Emina Ikeuchi², Tsukushi Yamawaki¹, Chinatsu Mori¹, Kouhei Tsumoto^1,2 (1.Dept. of Chem. Biotech., Sch. of Eng., Univ. of Tokyo, 2.Dept. of Bioeng., Sch. of Eng., Univ. of Tokyo)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-638] Delivery of IgG to the cerebrospinal fluid following intranasal administration with cell penetrating peptide.

^〇Taiki Terado¹, Takuya Noda¹, Mai Yamashiro¹, Takumi Iima¹, Riyo Kashimoto¹, Narumi Hashikawa¹, Naoya Hashikawa¹ (Okayama university of science)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-639(1T18a-09)] Machine-learning-assisted molecular evolution for antibody fragment maturation

Tomoyuki Ito¹, Sakiya Kawada¹, Hikaru Nakazawa¹, Akikazu Murakami^2,3, ^〇Mitsuo Umetsu^1,4 (1.Graduate School of Engineering, Tohoku University, 2.Graduate School Biomedical Sciences, Tokushima University, 3.RePHAGEN Co. Ltd., 4.Advanced Intelligence Project , AIP)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-640] Stabilization of the CH₂ domain, the least stable domain in antibody therapeutics, to prevent aggregation

^〇Kosuke Oyama¹, Jose Manuel Martinez Caaveiro², Naoya Matsunaga³, Kengo Hamamura³, Yuya Yoshida³, Shigehiro Ohdo¹, Tadashi Ueda¹ (1.Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 2.Department of Global Healthcare, Faculty of Pharmaceutical Sciences, Kyushu University, 3.Department of Clinical Pharmacokinetics, Faculty of Pharmaceutical Sciences, Kyushu University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-641] Preparation and evaluation of antibody fragments against SARS CoV-2 for crystal structure analysis

^〇Kosei Aramaki¹, Rikako Matsujo¹, Yoshihiro Kobashigawa², Takashi Sato², Takeo Kuwata³, Shuzo Matsushita³, Takao Arimori⁴, Hiroshi Morioka² (1.School of pharmacy,Kumamoto Univ., 2.Graduate School of Pharmaceutical Science,Kumamoto Univ., 3.Joint Reserch Center for Human Retrovirus Infection,Kumamoto Univ., 4.Institute for Protein Reseach,Osaka Univ.)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-642(1T18a-10)] Combined immunotherapy of chimeric antigen receptor T cells targeting STEAP1 with extracellular matrix-targeted IL-12 for advanced prostate cancer

^〇Koichi Sasaki¹, Bhatia Vipul², Ishihara Jun¹, Lee John K.^2,3,4,5 (1.Department of Bioengineering, Imperial College London, 2.Human Biology Division, Fred Hutchinson Cancer Center, 3.Division of Medical Oncology, University of Washington, 4.Department of Pathology and Laboratory Medicine, University of Washington, 5.Clinical Research Division, Fred Hutchinson Cancer Center)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-643] Efficient Generation of Cross-Reactive Antibodies Targeting Human and Mouse Specific Proteins Through Integrating Phage Display, High Throughput Sequencing, and Machine Learning

Muhammad Feisal Jatnika¹, Abdur Rafique¹, ^〇Yuji Ito¹ (Department of Chemistry Program, Department of Science, Graduate School of Science and Engineering, Kagoshima University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-644] Unique cell recovery technology without enzymatic digestion

^〇Yuzo Kasuya¹, Asumi Yoshihara¹, Eriko Ikeda¹ (CellSeed Inc.)

The 96th Annual Meeting of the Japanese Biochemical Society