Symposium

[S05] Developmental Biology in Stem Cell Research and Regenerative Medicine

Fri. Jun 8, 2018 4:00 PM - 6:30 PM Room A (5F　Big Hall)

Chairpersons : Hideyuki Okano (Keio Univ. School of Medicine) / Kiyokazu Agata (Gakushuin Univ.)

In 2006, Yamanaka’ group developed iPS cell technologies. Since then, there is an emerging interest in the stem cell research into the field of medical science and basic biology. Application of stem cell research is not restricted to regenerative medicine, but disease modeling/drug development and cancer immunotherapy are becoming its very important targets. In the basic biology, stem cell research, particularly iPS cell technology is being applied to i) in vitro organogenesis using organoid, ii) human embryology, iii) human-animal chimera, iv) evo-devo research and v) human reproductive biology. Namely, the re-union of stem cell research and developmental biology is becoming increasingly hot. Topics in this field will be presented and discussed in this symposium.

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4:00 PM - 4:05 PM

[S05-Introduction] Introduction

4:05 PM - 4:30 PM

[S05-01] Regeneration, Stem Cells and Medicine

*Kiyokazu Agata¹ (1. Dept. Life Sci., Gakushuin Univ.)

4:30 PM - 4:45 PM

[S05-02] In vivo reprogramming of postmitotic neocortical neurons into different neuronal subtypes

*Koji Oishi¹, Kazunori Nakajima¹ (1. Keio University School of Medicine)

4:45 PM - 5:10 PM

[S05-03] In vitro and in vivo cell dynamics analysis of iPSC-derived neural crest cells from CHARGE patients harboring CHD7 mutations reveals deficit in defective delamination, migration and motility of CHARGE syndrome

*Hironobu Okuno¹, Francois Renault Mihara¹, Shigeki Ohta¹, Kimiko Fukuda², Kenji Kurosawa³, Wado Akamatsu⁴, Tsukasa Sanosaka¹, Jun Koyama¹, Kanehiro Hayashi¹, Kazunori Nakajima¹, Takao Takahashi¹, Joanna Wysocka⁵, Kenjiro Kosaki¹, Hideyuki Okano¹ (1. Keio University School of Medicine, 2. Tokyo Metropolitan University, 3. Kanagawa Children's Medical Center, 4. Juntendo University School of Medicine, 5. Stanford University School of Medicine)

5:10 PM - 5:35 PM

[S05-04] Kidney Organoids for Disease Modeling and Regenerative Medicine

*Ryuji Morizane^1,2,3 (1. Harvard Medical School, 2. Brigham and Women's Hospital, 3. Harvard Stem Cell Institute)

5:35 PM - 6:00 PM

[S05-05] Modeling of Human Neurological/Psychiatric Disorders using iPS cells and Transgenic Non-Human Primates

*Hideyuki Okano¹ (1. Keio University School of Medicine)

6:00 PM - 6:25 PM

[S05-06] Generation of “whole organ” by interspecies organogenesis

*Tomoyuki Yamaguchi¹ (1. University of Tokyo, The Institute of Medical Science)

6:25 PM - 6:30 PM

[S05-Closing Remarks] Closing Remarks

Session information