[31-413-am] Natural medicines and biological products

Sun. Mar 31, 2024 8:30 AM - 9:30 AM [Room 413] Conference Center 413 (4F)

Chair: Naoki Umezawa, Ayato Sato

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8:30 AM - 8:42 AM

[31-413-am01S] Synthesis and structure-activity relationship of new analogs of cortistatin A

○Yuri Fujimoto¹, Nao Kitamura¹, Erina Ijuin², Saki Watanabe¹, Yuya Kizaki², Hanami Suzuki², Naoyuki Kotoku^1,2 (1. Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2. Coll. Pharm. Sci., Ritsumeikan Univ.)

8:42 AM - 8:54 AM

[31-413-am02S] Synthesis of polyketide-peptide hybrid-like macrocyclic compounds on DNA aimed at constructing DNA-encoded libraries.

○Soya Koremura¹, Akihiro Sugawara¹, Yohei Morishita¹, Taro Ozaki¹, Teigo Asai¹ (1. Grad. Sci. Pharm. Sci., Tohoku Univ.)

8:54 AM - 9:06 AM

[31-413-am03S] Discovery of hydrophobic tag-based degraders targeting lysine-specific demethylase 1

○SHENGWANG YU¹, Yasunobu Yamashita¹, Yuri Takada¹, Yukihiro Itoh¹, Takayoshi Suzuki¹ (1. SANKEN, Osaka Univ.)

9:06 AM - 9:18 AM

[31-413-am04S] Enhancing T-cell activation: Synthesis of meta-carboranes regulating CD28 binding to SH2 domains of Grb2 and PI3K

○YUJIE SHAO¹, Yasunobu Asawa¹, Shuhei Ogawa², Saki Ochi³, Atsushi Yoshimori⁴, Masayuki Oda³, Hiroyuki Nakamura^1,5 (1. School of Life Science and Technology, Tokyo Institute of Technology., 2. Research Institute for Biomedical Sciences, Tokyo University of Science., 3. Graduate School of Life and Environmental Sciences, Kyoto Prefectural University., 4. Institute for Theoretical Medicine, Inc., 5. Institute of Innovative Research, Tokyo Institute of Technology)

9:18 AM - 9:30 AM

[31-413-am05] Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates

○Sadhanendu Samanta¹, Jin Cui^1,2, Yasunari Otsuka¹, Takumi Watanabe¹, Masakatsu Shibasaki¹ (1. Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki Shinagawa-ku, Tokyo, 141-0021, Japan., 2. Center for Innovative Drug Discovery, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Pharmacy, Fudan University, Shanghai, P.R. China. )

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