[総合討論] 総合討論

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 11:20 AM - 11:30 AM

[Introduction] Introduction

〇藤森浩彰¹ (1.国立がん研究センター研究所)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:00 AM - 9:02 AM

[4W6-1] Studies on the development of a novel anticancer drug targeting NAD⁺ biosynthetic key enzyme, nicotinamide phosphoribosyltransferase

〇Akira Sato¹, Yoko Ogino¹, Yuri Shibasaki¹, Kiyotaka Katsuragi¹, Atsushi Yoshimori², Takahiro Oyama³, Hideaki Abe³, Sei-chi Tanuma^1,4 (1.Dept. of Biochem., Fac. of Pharm. Sci., Tokyo Univ. of Sci., 2.Inst. for Theoretical Med., Inc., 3.Hinoki Shinyaku Co., Ltd, 4.Genome & Drug Res. Ctr., Tokyo Univ. of Sci.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:02 AM - 9:13 AM

[4W6-2] Interaction between polyADP-ribosylation and AKT pathways

〇Masakazu Tanaka¹, Chieri Ishizaki-Ida^2,3, Sachiko Yamashita², Yuka Sasaki⁴, Mitsuko Masutani⁴, Junichi Fujisawa¹, Masanao Miwa² (1.Dept. Microbiol., Kansai Med. Univ., 2.Grad. Sch. Biosci., Nagahama Inst. Bio-Sci. & Tech., 3.Dep. Applied Life Studies, College of Nagoya Women's Univ., 4.Div.Genome Stability Res.,Natl.Cancer Ctr.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:13 AM - 9:28 AM

[4W6-3] ADP-ribosyl-acceptor hydrolase 3 suppresses poly(ADP-ribose) polymerase 1-dependent cell death, parthanatos, during oxidative stress

〇Masato Mashimo^1,2, Jiro Kato², Joel Moss² (1.Dept. of Pharmacol., Fac. of Pharmaceut. Sci., DWC, 2.CPB, NHLBI, NIH)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:28 AM - 9:43 AM

[4W6-4] PARP-1 and PARG promote genomic integrity by regulating resection of DNA double-strand breaks

〇Akira Motegi¹, Junhui Wang^2,3, Hiroaki Fujimori², Yoshio Miki³, Mitsuko Masutani^2,4 (1.Dept. of Rad. Genet., Grad. Sch. of Med., Kyoto Univ., 2.Div. of Chemotherapy and Clinical Res., Natl. Ca. Cent. Res. Inst., 3.Dept. of Mol. Genet., Med. Res. Inst., Tokyo Med. Dent. Univ., 4.Dept. of Front. Life Sci., Grad. Sch. of Biomed. Sci., Nagasaki Univ.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:43 AM - 10:02 AM

[4W6-5] BRCA1 and PARP treatment: LSD1 increases PARP efficacy and NF-kB inhibiton over comes resistance.

〇Ko Sato¹, Anna S. Sedukhina¹ (1.Dept. of Pharmacogenomics, Grad. Sch. of Med., St. Marianna Univ.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:02 AM - 10:21 AM

[4W6-6] DNMT3B, a novel predictive marker for synthetic lethal cancer-therapy using PARP inhibitor

〇Hiroaki Fujimori^1,2, Hiroaki Mukai³, Syoji Imamichi¹, Yasufumi Murakami³, Mitsuko Masutani^1,2 (1.Natl. Cancer Center, Res. Inst., Div. of Chemo and Clinical Res., 2.Nagasaki Uni., Grad. Sch of Biomed. Sci., Frontier Life Sci., 3.Tokyo Uni. of Sci., Indust. Sci. and Tech.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:21 AM - 10:32 AM

[4W6-7] Multifunction of tankyrase PARPs and its application to drug development

〇Hiroyuki Seimiya¹ (1.Div. Mol. Biother., JFCR Cancer Chemother. Ctr.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:32 AM - 10:52 AM

[4W6-8] Creation of new anticancer drugs targeting poly(ADP-ribose) glycohydrolase

〇Sei-chi Tanuma^1,2, Ryosuke Suzuki¹, Takahiro Oyama³, Akira Sato^1,2, Atsushi Yoshimori⁴, Hideaki Abe³ (1.Facul. Pharm. Sci., Tokyo Univ of Sci., 2.Genome and Drug Res. Center, Tokyo Univ of Sci., 3.Hinoki Shinyaku Co.,Ltd., 4.Inst. of Theol. Med. Co.,Ltd.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:52 AM - 11:11 AM