[3P1182(4T特-06)] Inhibition of the Oxygen Sensor PHD2 in the Liver Improves Survival in Lactic Acidosis by Activating the Cori Cycle

〇Tomohiro Suhara^1,2, Takako Hishiki^1,3,4,5, Masataka Kasahara^1,6, Noriyo Hayakawa^1,3,4, Tomoko Oyaizu^1,2, Tsuyoshi Nakanishi^1,7, Akiko Kubo^1,4, Hiroshi Morisaki², William G. Kaelin Jr.^8,9, Makoto Suematsu^1,4, Yoji A. Minamishima^1,4 (1.Dept. of Biochem., Keio Univ. Sch. of Med., 2.Dept. of Anesth., Keio Univ. Sch. of Med., 3.Dept. of TR Center., Keio Univ. Sch. of Med., 4.JST-ERATO Suematsu Gas Biology Project, 5.JST-CREST, 6.Dept. of Pharm., Tokyo Dental College, 7.MS Business Unit, Shimadzu Corporation, 8.Dept. of Med. Onc., Dana-Farber Cancer Inst. and Brigham and Women's Hosp., Harvard Med. Sch., Boston, 9.Howard Hughes Med. Inst., Chevy Chase, Maryland)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1183(4T特-07)] ASK1 signaling regulates brown adipocyte maturation

〇Kazuki Hattori¹, Isao Naguro¹, Hidenori Ichijo¹ (1.Cell Signaling, Grad. Sch. of Pharmaceut. Sci., Univ. of Tokyo)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1184(4T特-08)] Post-Transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity

〇Akinori Takahashi¹, Masahiro Morita², Toru Suzuki¹, Tadashi Yamamoto¹ (1.Cell Signal Unit, Okinawa Institute of Science and Technology, 2.Department of Biochemistry and Goodman Cancer Research Centre, McGill University)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1185(4T特-09)] Molecular mechanism of anti-obesity effect and increased energy expenditure in BMP-3b transgenic mice.

〇Jun Hino¹, Masashi Nakatani², Yuji Arai³, Kunihiro Tsuchida², Mikiya Miyazato¹, Kenji Kangawa¹ (1.Dept. of Biochem. Natl. Cerebral Cardiovasc. Ctr. Res. Inst., 2.Div. for Therapies against Intractable Diseases, Inst. for Comprehensive Medical Science, Fujita Health Univ., 3. Dept. of Mol. Biol., Natl. Cerebral Cardiovasc. Ctr. Res. Inst.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1186(4T特-10)] Regulation of ChREBP by nuclear import and export signals: Identification of new nuclear localization signal in the C-terminal region of ChREBP.

〇Tsutomu Nakagawa¹, Yuki Yoshimura¹, Haruhiko Sakiyama², Kazuhiro Yamamoto³, Noriko Fujiwara², Keiichiro Suzuki², Midori Hirai^1,3 (1.Div. Pharmacokinetics, Dept of biochem. and mol. boil., Kobe Univ. Grad. Sch. of Med., 2.Dept. of Biochem., Hyogo Col. of Med., 3.Dept. of Pharmacy, Kobe Univ. Hospital)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1187(4T特-11)] MML-1/Mondo complexes regulate HLH-30/TFEB via TOR inhibition to promote longevity in response to signals from the reproductive system

〇Shuhei Nakamura¹, Oezlem Karalay¹, Philipp S. Jaeger¹, Makoto Horikawa¹, Corinna Klein⁴, Kayo Nakamura¹, Christian Latza¹, Sven E. Templer⁴, Christoph Dieterich⁴, Adam Antebi^1,2,3 (1.Dept. Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, 2.Dept. of Molecular and Cellular Biology, Huffington Center on Aging, Baylor College of Medicine, 3.Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Univ. of Cologne, 4.Bioinformatics Core Facility, Max Planck Institute for Biology of Ageing)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1188(4T特-12)] Knockout mice of neudesin, a secretory protein, were resistant to diet-induced obesity due to increased sympathetic nervous activity

〇Hiroya Ohta^1,2, Morichika Konishi^1,2, Daishi Hashimoto¹, Atsuki Kashio², Takayuki Mochiyama², Shigenobu Matsumura³, Kazuo Inoue³, Tohru Fushiki³, Yoshiaki Nakayama¹, Kazuwa Nakao⁴, Ikuo Kimura^2,5, Nobuyuki Itoh^2,4 (1.Dept. of Microbial Chemistry, Kobe Pharmaceutical Univ, 2.Dept. of Genetic Biochemistry, Grad. Sch. Pharm. Sci., Kyoto Univ, 3.Lab. of Nutr. Chem., Div. of Food Sci. Biotechnol., Grad. Sch. of Agric., Kyoto Univ, 4.Medical Innnovation Center, Grad. Sch. Med., Kyoto Univ, 5.Dept. of Appli. Biosci.,Tokyo Univ. of Agr. and Technol.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1189(4T特-13)] Improvement of insulin senseitivity by using SKIP-binding peptide within PAK1 kinase domain

〇Takeshi Ijuin¹, Tadaomi Takenawa² (1.Div. of Biochem., Kobe Univ. Grad. Sch. of Med., 2.Biosignal Res. Center, Org. of Adv. Sci. and Tech., Kobe Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1190(4T特-14)] Nardilysin is essential for the maintenance of pancreatic β-Cell function and identity

〇Kiyoto Nishi¹, Yuichi Sato², Mikiko Ohno¹, Yoshinori Hiraoka¹, Sayaka Saijo¹, Jiro Sakamoto¹, Po-Min Chen¹, Yusuke Morita¹, Shintaro Matsuda¹, Toru Kita³, Nobuya Inagaki², Takeshi Kimura¹, Eiichiro Nishi¹ (1.Dept. of Cardiovascular Med., Grad. Sch. of Med., Kyoto Univ., 2.Dept. of Diabetes and Clin. Nutr., Grad. Sch. of Med., Kyoto Univ, 3.Kobe City Medical Ctr General Hosp)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1191(4T特-15)] Regulatory mechanism of replicative lifespan by phosphate starvation response system in budding yeast

〇Tsubasa Maruhashi¹, Shan Jiang¹, Yuka Kamei¹, Yukio Mukai¹ (1. Grad. Sch. of Biosci., Nagahama Inst. of Bio-Sci. and Tech.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM