[2P-0748] Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-dependent Manner

〇Yoshinaga Kawano¹, Jun Nakae¹, Nobuyuki Watanabe², Tetsuhiro Kikuchi¹, Sanshiro Tateya³, Yoshikazu Tamori^4,5, Masafumi Onodera², Hiroshi Ito¹ (1.Div. of Endo.Metab.Nephro, Univ. of Keio, 2.Nat. Center for Child Health and Dev., 3.Hosp.of Kakogawa Cent. Civ., 4.Grad. Sch. of Med., Univ. of Kobe, 5.Hosp. of Chifune)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0749] Analysis of metabolic changes in host by gut microbiota for elucidation of low-protein adaptation mechanism

〇Eriko Tomitsuka^1,2, Hiroaki Masuoka³, Wataru Suda^4,5, Katsura Igai^1,6, Kiyoshi Tadokoro^1,7, Jun Baba⁸, Ayako Morita^1,9, Yuichi Naito¹⁰, Paul F Horwood¹¹, Andrew R Greenhill¹¹, Peter M Siba¹¹, Singo Odani¹², Kazumi Natsuhara¹³, Masahira Hattori⁴, Hidetoshi Morita¹⁴, Kazuhiro Hirayama³, Masahiro Umezaki¹ (1.Dept. of Hum. Ecology, Grad. Sch. of Med., Univ. of Tokyo, 2.Dept. of Health Chem., Faculty of Pharm.Sci., Niigata Univ. of Pharm., ALS., 3.Dept. of Veterinary Public Health, Faculty of Agriculture, Univ. of Tokyo, 4.Univ. of Tokyo, 5.Keio Univ., 6.Nagasaki Univ., 7.Akita Univ., 8.Wako Univ., 9.TMDU, 10.Fukushima Univ., 11.Papua New Guinea Institute of Medical Research, 12.Chiba Univ., 13.Japanese Red Cross Akita College of Nursing, 14.Okayama Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0750] Elucidation of the mechanisms of rice bran supplementation on the suppression of colitis development

〇Kazuki Tanaka^1,2, Wanping Aw¹, Masaru Tomita^1,2,3, Shinji Fukuda¹ (1.Inst. Adv. Bio. Sci., Keio Univ., 2.Dept. Environment & Info. Studies., Keio Univ., 3.Grad. Sch. Media and Governance)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0751] Gut microbial utilization of choline alters lipid profiles and one carbon metabolism in the host

〇Kazuyuki Kasahara¹, Kymberleigh A. Romano¹, Federico E. Rey¹ (1.Dept. of Bacteriol., Univ. of Wisconsin-Madison)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0752] Androgen deprivation changes gut microbiota and causes metabolic syndrome in male mice

〇Naoki Harada¹, Ryo Hanaoka¹, Hiroshi Inui², Ryoichi Yamaji¹ (1.Div. Appl. Life Sci., Grad. Sch. of Life Environ. Sci., Osaka Pref. Univ., 2.Div. Nutr., Grad. Sch. of Compr. Rehab., Osaka Pref. Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0753] Role of steroidogenic acute regulatory protein-related lipid transfer domain containing 10 (STARD10) in the development of lipid droplet in the liver

〇Masanori Ito¹, Taichiro Tomida¹, Keiichi Takahashi², Hideo Shindou², Yoshinori Mikami¹, Shingo Murakami¹, Takao Shimizu^2,3, Satomi Adachi-Akahane¹ (1.Dept. Physiol., Fac. Med., Toho Univ., 2.Dept. Lipidsignal. NCGM, 3.Dept. Lipidmics, Grad. Med., Unvi. of Tokyo)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0754] Dual functions of Dyrk1 to regulate hepatic gluconeogenesis through PGC-1α and GCN5-CITED2-PKA module

〇Masaru Mitsushima¹, Mashito Sakai¹, Tomoko Tsujimura-Hayakawa¹, Takashi Yagi^1,2, Hiroyuki Yano^1,2, Takao Naganuma¹, Satoshi Iida¹, Fengying Gao¹, Masato Kasuga³, Michihiro Matsumoto¹ (1.Dept. of Mol. Metab. Reg., Diabetes Res. Cent., Inst., NCGM, 2.Dept. of Bioreg., Nippon Medical Sch., 3.NCGM)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0755] KLF15 enables rapid switching between lipogenesis and gluconeogenesis during fasting.

〇Yoshinori Takeuchi^1,2, Naoya Yahagi^1,2, Yuichi Aita^1,2, Yuki Murayama^1,2, Yoshikazu Sawada^1,2, Xiaoying Piao^1,2, Naoki Toya^1,2, Yukari Oya^1,2, Akito Shikama^1,2, Makiko Tatsumi-Nishi^1,2, Yukari Masuda^1,3, Midori Kubota^1,3, Yoshihiko Izumida^1,3, Motohiro Sekiya², Takashi Matsuzaka², Yoshimi Nakagawa², Yasushi Kawakami², Nobuhiro Yamada², Hitoshi Shimano² (1.NGRG, 2.Dept. of Internal. Med., Faculty of Med., Univ. of Tsukuba, 3.Dept. of Internal Med., Grad. Sch. of Med., Univ. of Tokyo)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0756] Role of hepatic miRNA-regulatory machinery in metabolic homeostasis

〇Takahisa Nakamura¹ (1.Div. of Endocrinol., Cincinnati Chn's Hosp.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0757] Analysis of proteasome-dependent lipogenic pathway in hepatocytes

〇Seira Hoshikawa^1,2, Asami Watahiki^2,3, Hidefumi Fukushima², Satoshi Fukumoto^1,2, Hiroyuki Inuzuka² (1.Pediatric dentistry, dent., Tohoku Univ., 2.Center for Advanced Stem Cell and Regenerative Research , dent., Tohoku Univ., 3.Molecular and Regenerative Prosthodontics, dent., Tohoku Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan