[1P-078] Application of chromosome engineering technology (6): Construction of human iPS cells with partial monosomy of chromosome 21 and search for essential regions

^○Rina Komazaki¹, Yuki Ishizu¹, Masaya Egawa¹, Yusaku Okano¹, Taku Yunomae¹, Yusuke Ohkame², Shuta Takata², Chihiro Yoshimatsu³, Kyoutarou Yamazaki³, Teruhiko Suzuki⁴, Yasunori Aizawa⁵, Narumi Uno¹, Yasuhiro Kazuki^2,3,6, Kazuma Tomizuka¹ (1.Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm and Life Sci., 2.CERC, Tottori Univ., 3.Div. of Chromo. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 4.Stem Cell Proj., Tokyo Metropol. Inst. Med. Sci., 5.Sch. Life Sci. Tech., Tokyo Tech., 6.Chr. Eng. Group, ExCELLS)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-079] Application of chromosome engineering technology (7): Generation of elephantized mice with elephant-specific gene functions and analysis of their contribution to carcinogenesis inhibition

^○Kyotaro Yamazaki¹, Yasuhiro Kazuki^1,2,3 (1.Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2.CERC, Tottori Univ., 3.Chr. Eng. Group, ExCELLS)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-080] Application of chromosome engineering technology (8) : Replacement of HLA gene using artificial chromosome and gene editing technology

^○Wakana Nakagawa¹, Takashi Moriwaki², Nanami Kishima¹, Yuji Nakayama³, Narumi Uno⁴, Kazuma Tomizuka⁴, Yasuhiro Kazuki^5,2,6 (1.Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2.Sch. of Life Sci., Facul. of Med., Tottori Univ., 3.RIC., Res Init & Promo., Tottori Univ., 4.Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 5.Chr. Eng. Group, ExCELLS., 6.CERC, Tottori Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-081] Application of chromosome engineering technology (9): Generation and analysis of humanized mice retaining the mouse artificial chromosome harboring HLA class I cluster

^○Nanami Kishima¹, Takashi Moriwaki^1,2, Kanako Kazuki², Wakana Nakagawa¹, Narumi Uno³, Kazuma Tomizuka³, Teruhiko Suzuki⁴, Yasuhiro Kazuki^1,2,5 (1.Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2.CERC, Tottori Univ., 3.Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 4.Stem Cell Proj., Tokyo Metropol. Inst. Med. Sci., 5.Chr. Eng. Group, ExCELLS)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-082] Application of chromosome engineering technology (10):Development of human IgH/Igλantibody-producing mice by using artificial chromosome.

^○Kazuto Shimoya¹, Takashi Moriwaki^2,1, Satoshi Abe³, Akane Okada¹, Kanako Kazuki², Yasuhiro Kazuki^4,2,1 (1.Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2.CERC, Tottori Univ., 3.Trans Chromosomics Inc., 4.Chr. Eng. Group, ExCELLS)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-083] Application of chromosome engineering technology (11) : Improvement of fully human antibody producing mice aimed to increase the expression levels of membrane-bound antibodies

^○Mirei Matsuoka¹, Takashi Moriwaki², Kanako Kazuki³, Shusei Hamamichi³, Satoshi Abe⁴, Kazuma Tomizuka⁵, Mitsuo Oshimura⁴, Yasuhiro Kazuki^2,3,6 (1.Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2.Sch. of Life Sci., Facul. of Med., Tottori Univ., 3.CERC, Tottori Univ., 4.Trans Chromosomics Inc., 5.Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 6.Chr. Eng. Group, ExCELLS)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-084] Application of chromosome engineering technology (12): Analysis of antibody affinity maturation in fully human antibody producing mice

^○Takashi Moriwaki^1,2, Hiroyuki Satofuka², Satoshi Abe³, Hiroshi Tanaka³, Kayoko Morimoto³, Kazuma Tomizuka⁴, Mitsuo Oshimura³, Yoshihiro Baba⁵, Yasuhiro Kazuki^1,2,6 (1.Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 2.CERC, Tottori Univ., 3.Trans Chromosomics Inc., 4.Lab. of Bioeng., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 5.Div. Immunol. and Genome Biol., Depart. of Mol. Genet., Med. Inst. of Bioreg., Kyushu Univ., 6.Chr. Eng. Group, ExCELLS)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-085] High-order structure of DNA-protein complex by chemically modified histone-like protein

^○Natsumi Araya, Fumiaki Tomoike, Tetsuji Okada (Dept. of Biol. Sci., Fac. of Sci., Gakusyuin Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-086] A pathway to produce piRNAs from endogenous protein-coding sequences supports Drosophila spermatogenesis

^○Taichiro Iki, Shinichi Kawaguchi, Toshie Kai (Grad. Sch. of FBS (Frontier Biosciences), Osaka Univ)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-087] Solution in Microwells Exchange System

^○Yosuke Horiuchi (TOPPAN INC.)

The 45th Annual Meeting of the Molecular Biology Society of Japan