[1P-772] Elucidation of SARS-CoV-2-mediated airway epithelial-endothelial barrier disruption using airway-on-a-chips

^○Rina Hashimoto¹, Junya Takahashi², Kaori Kosugi¹, Masaki Yamamoto³, Yasushi Fujio², Miki Nagao³, Yoshiaki Okada², Kazuo Takayama¹ (1.CiRA, Kyoto univ., 2.Lab. of Clin. Sci. and Biomed., Grad. Sch. of Pharm. Sci., Osaka Univ., 3.Dept. of Clin. Lab. Med., Grad. Sch. of Med., Kyoto Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-773] Molecular mechanism of severe COVID-19 regulated by non-structural proteins of SARS-CoV-2

^○Mai Kishimoto¹, Shinsuke Toba^2,3, Kentaro Uemura^2,3,4, Yuki Maruyama^2,3, Shinji Kusakabe^2,3, Akihiko Sato^2,3, Yasuko Orba¹, Hirofumi Sawa¹, Michihito Sasaki¹ (1.Division of Molecular Pathobiology, IIZC, Hokkaido Univ., 2.Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd., 3.Division of Anti-Virus Drug Research, IIZC, Hokkaido Univ., 4.Laboratory of Virus Control, RIMD, Osaka Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-774] Identification of exocyst complex component 2 as a pivotal host factor for SARS-CoV-2

^○Yi Renxing¹, Hashimoto Rina¹, Sakamoto Ayaka¹, Takahashi Kazutoshi¹, Takayama Kazuo^1,2 (1.Center for iPS Cell Research and Application (CiRA), Kyoto University, 2.AMED-CREST, Japan Agency for Medical Research and Development (AMED))

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-775] Translational landscape of a giant virus

^○Zhang Ruixuan¹, Hikida Hiroyuki¹, Shichino Yuichi^2,3, Mito Mari^2,3, Iwasaki Shintaro^2,3, Ogata Hiroyuki¹ (1.Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji 611-0011, Japan, 2.Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan, 3.RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama 351-0198, Japan)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-776] Antiviral targeting of phosphoprotein that is essential cofactor of the viral RNA polymerase

^○Koyu Hara, Hiroshi Watanabe (Div. Infect. Dis., Kurume Univ. Sch. Med.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-777] Analysis of the effect of cytoplasmic accumulation of TDP-43 observed in West Nile infection on the neuropathogenesis

^○Shintaro Kobayashi¹, Keisuke Maezono¹, Yuji Takahashi¹, Passawat THAMMAHAKIN¹, Kentaro Yoshii², Hiroaki Kariwa¹ (1.Lab. of Pub. Heal., Facul. of Vet. Med., Hokkaido Univ., 2.CCPID., Nagasaki Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-778] Search for Short Linear Motif in Viral Proteins by Transformer

^○Ryunosuke Kinemuchi¹, Manabu Igarashi², Takashi Abe¹ (1.Grad. Sch. of Sci. & Tech., Niigata Univ., 2.IIZC, Hokkaido Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-779] SARS-CoV-2 Nucleocapsid protein inhibits anti-viral stress granules formation and Type I/III interferon production via binding to PKR.

^○Yuna Aoki¹, Koji Onomoto¹, Mitsutoshi Yoneyama^1,2 (1.Div. of Mol. Immunol., Med. Mycol. Res. Ctr., Chiba Univ., 2.Res. Inst. of Disaster Med., Chiba Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-780] Analysis of cis-elements contributing to nuclear export of murine leukemia virus full-length mRNA

^○Keisuke Yonebayashi¹, Tsukasa Koreeda¹, Sachie Torii¹, Sayaka TakaseYoden^1,2 (1.Dept of Biosci., Grad. Sch. of Sci. and Eng., Soka Univ., 2.GaLSIC, Soka Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-781] Identification of cellular senescence-related genes using genome-wide transcriptome analysis of ASF-4 series of fibroblasts prepared from a single donor at different ages

^○Nobuyuki Horie¹, Kazuhiko Kaji² (1.Health and Sci., Nagoya Women’s Univ., 2.Research Lab., KOSE Corp.)

The 45th Annual Meeting of the Molecular Biology Society of Japan