[1P-722] Comprehensive search for functional variants related to Alzheimer's disease

^○Hsiaoju Lo, Naoto Kubota, Mikita Suyama (Div. of Bioinfo, MIB, Kyushu Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-723] Globally impaired ER-Golgi trafficking via ER calcium depletion as a cellular pathogenesis of Pelizaeus-Merzbacher Disease

^○Heng Li, Reiko Mishima, Goto Goto, Ken Inoue (Dept. of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-724] Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1

^○Fumio Takahashi, Takashi Yamamura, Shinji Oki (Dept. of Immunol., Natl Inst Neurol. NCNP)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-725] In vivo assessment of progressive astrogliosis in the pathophysiological cascade of rTg4510 tauopathy animal brains

^○Masafumi Shimojo¹, Takeharu Minamihisamatsu¹, Manami Takahashi¹, Hiroyuki Takuwa¹, Yumi Matsushita¹, Rin Yanai¹, Keiichiro Minatohara¹, MingRong Zhang², Naruhiko Sahara¹, Makoto Higuchi¹ (1.Dept. of Func. Brain Imaging., QST, 2.Dept. of Adv. Nuc. Med. Sci., QST)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-726] Effects of α-synuclein overexpression on neurotransmitter receptor localization

^○Ayano Chikuma¹, Hiroko Bannai², Shigeo Sakuragi² (1.Dept. of Elec. Eng. Biosci., Grad. Sch. of Adv. Sci. Eng., Waseda univ., 2.Fac. of Sci. Eng., Waseda univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-727] Roles of mitochondrial localization in proteostasis decline in neurons during aging

^○Kanako Shinno¹, Emiko Suzuki^2,3,1, Yuri Miura⁴, Koichi Iijima.M^5,6, Kanae Ando^1,7 (1.Grad Sch of Sci, Tokyo Metropolitan Univ., 2.NIG, 3.Sch of Life Sci, SOKENDAI, 4.TMIG, 5.NCGG, 6.Grad Sch of Pharm Sci, Nagoya City Univ., 7.Sch of Sci, Tokyo Metropolitan Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-728] Generation of a-synuclein mutant protein library to screen amino acids responsible for aggregation

^○Tomoyuki Yamanaka^1,2, Akiko Hiyama², Hideaki Matsui¹, Nobuyuki Nukina² (1.Brain Res. Inst., Niigata Univ., 2.Doshisha Univ. Grad Sch. Brain Sci.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-729] Expression analysis in mice lacking enhancer sequences (CAS) in the Snrpn intron 1

^○tatsuya kishino (Division of Functional Genomics, Graduate School of Biomedical Sciences, Nagasaki University)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-730] Dysregulation of ribosome-associated quality control elicits neurodevelopmental disorders via overaccumulation of TTC3

^○Ryo Endo¹, YiKai Chen¹, John Burke¹, Noriko Takashima¹, Nayan Suryawanshi¹, Kelvin K. Hui¹, Tatsuhiko Miyazaki², Motomasa Tanaka¹ (1.Lab. for Protein Conformation Diseases, CBS, RIKEN, 2.Pathol. Div., Gifu Univ. Hosp.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1P-731] Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability

^○Takumi Taketomi¹, Takunori Yasuda², Rikuri Morita³, Yasuteru Shigeta³, Ryuhei Harada³, Fuminori Tsuruta^4,1 (1.PhD. Prog. in Hum. Biol., Grad. Sch. of Comp. Hum. Sci., Univ. of Tsukuba, 2.PhD. Prog. in Biol., Grad. Sch. of Life and Env. Sci., Univ. of Tsukuba, 3.Center for Comp. Sci., Univ. of Tsukuba, 4.Fac. of Life and Env. Sci., Univ. of Tsukuba)

The 45th Annual Meeting of the Molecular Biology Society of Japan