[3P-653] The impact of CDK12 inhibition on sunitinib-induced DNA damage response and drug resistance in human RCC

Chow PoMing^1,2, ^○Dong JunRen^1,2, Huang KuoHow^1,2 (1.Dept. of Uro., Nat'l. Taiwan Univ. Hosp., 2.Dept. of Uro., Coll. of Med., Nat'l. Taiwan Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-654] Biotinylation method for analysis of protein degrader-dependent interaction using a proximity biotinylation enzyme AirID

^○Yuto Horiuchi¹, Satoshi Yamanaka^2,1, Kohei Nishino³, Hidetaka Kosako³, Tatsuya Sawasaki¹ (1.Division of Cell-Free Life Sciences, Proteo-Science Center, Ehime University (Div. Cell-Free Sci., PROS, Ehime Univ.), 2.Division of Proteo-interactome, Proteo-Science Center, Ehime University (Div. Proteo-interactome, PROS, Ehime Univ.), 3.Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences (Inst. Adv. Med. Sci., Tokushima Univ.))

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-655] Establishment of cholangiocarcinoma organoids and treatment targeting intratumoral neutrophils

^○Osamu Sugahara, Daisuke Koga, Tsunaki Higa, Takeru Oka, Shigeaki Sugiyama, Reona Wada, Keiichi Nakayama (Dept. of MCB, MIB, Univ. of Kyushu)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-656] Benefits of combined treatment of HDAC inhibitor and TOPO isomerase inhibitor on synovial sarcoma cells

^○Satoru Sasagawa¹, Toru Wakamatsu², Jun Kumai³, Yoshihiro Yui³ (1.Mol. Biol. Lab., Res. Inst., Nozaki Tokushukai HP, 2.Dept. Musculoskeletal Oncol., Osaka Int. Cancer Ctr., 3.Sarcoma treat. Lab., Res. Inst., Nozaki Tokushukai HP)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-657] Action mechanism of the anti-T-ALL compounds that specifically kill T-cell acute lymphoblastic leukemia-derived cells

^○Shota Hoyano^1,2, Humiya Seki^3,2, Chihiro Nakata^3,2, Takuya Yagi^3,2, Yasumasa Saito⁴, Tomoya Azuma⁵, Shojiro Maki⁶, Takahiko Hara^2,1,3 (1.Dept.of Biol.Sci.,Grad.Sch.of Sci., Univ. of Tokyo Metropolitan, 2.Dept. of Ste. Cell.Reg., Ins. of Tokyo. Med. Res, 3.Dept.of Heal.Sci and Biomed Eng., Grad. Sch. of Med and Den.Sci, 4.Cen. of Bas.Tec, Ins. of Tokyo. Med. Res, 5.Dep. of Eng. Sci., Grad. Sch. of Info. and Eng., Univ. of Ele. Com, 6.Dep. of Eng. Sci., Univ. of Ele. Com)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-658] Reconstitution of tumor immune microenvironment by interleukin 4 Induced 1 (IL4I1) in a mouse melanoma model

^○Shiho Hirose^1,2, Tetsuo Mashima¹, Kunbai En¹, Shinichi Torii³, Toshiro Migita⁴, Hiroyuki Seimiya^1,2 (1.Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 2.Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 3.Vermilion Therapeutics Inc., 4.Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-659] Purification of cancer antigen p53 expressed in transgenic silk worm and application for cancer immunotherapy

^○Momoka Horikawa¹, Kenichiro Tatematsu², Hideki Sezutsu², Makoto Ikeda³, Shunsuke Takizawa³, Kazuaki Chikamatsu⁴ (1.Fac. of Sci. Tec., Univ. of Gunma, 2.Division of Silk-Producing Insect Biotechnology, NARO, 3.Gunma Sericultural Technology Center, 4.Grad. Sch. of Med., Univ. of Gunma)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-660] Restoration of soluble IL-33 receptor expression confined to the hypoxic region of colorectal cancer suppresses tumor growth and metastasis

^○Miho Akimoto, Takao Susa, Noriyuki Okudaira, Tomoki Okazaki, Mimi TamamoriAdachi (Dept. of Biochem., Teikyo Univ. Sch. of Med.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-661] Molecular mechanisms of temozolomide-resistance in human glioblastoma cells

^○Ryo Okamoto, Koki Toya, Akira Sato (Dept. Biochem., Fac. Pharm. Sci., Tokyo Univ. Sci.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-662] Method of Improving Immuno-Assay Sensitivity Using Giant Magneto-Resistive Sensor

^○Chihiro Manri¹, Sebastian J. Osterfeld², Yu Heng², Masayoshi Momiyama³, Takashi Nakasawa³, Toshiro Saito⁴, Naoshi Itabashi¹ (1.Healthcare Innovation Center, R&D Group, Hitachi Ltd., 2.MagArray, Inc., 3.L&M Systems Business Div., Hitachi High-Tech, 4.L&M Systems Product Div., Hitachi High-Tech)

The 45th Annual Meeting of the Molecular Biology Society of Japan