[S05] Developmental Biology in Stem Cell Research and Regenerative Medicine

[S05-03] In vitro and in vivo cell dynamics analysis of iPSC-derived neural crest cells from CHARGE patients harboring CHD7 mutations reveals deficit in defective delamination, migration and motility of CHARGE syndrome

*Hironobu Okuno¹, Francois Renault Mihara¹, Shigeki Ohta¹, Kimiko Fukuda², Kenji Kurosawa³, Wado Akamatsu⁴, Tsukasa Sanosaka¹, Jun Koyama¹, Kanehiro Hayashi¹, Kazunori Nakajima¹, Takao Takahashi¹, Joanna Wysocka⁵, Kenjiro Kosaki¹, Hideyuki Okano¹ (1. Keio University School of Medicine, 2. Tokyo Metropolitan University, 3. Kanagawa Children's Medical Center, 4. Juntendo University School of Medicine, 5. Stanford University School of Medicine)

Keywords:CHD7, CHARGE syndrome, nearal crest, induced pluripotent stem cells, migration