EARTH

[3801-11-08] A Study of drug loading capacity of sodium alginate recovered from waste seaweed

○Lakshmi prasanna Nalluri¹, Ching-Hwa Lee¹, Srinivasa Rao Popuri² (1. Da-Yeh University, 2. The University of The West Indies (Cave Hill Campus))

Chairman: Jonghyun Lee（Chungnam National University）, Liyuan Chai (Central South University)

Keywords:drug loading, sodium alginate, recover, waste

Sodium alginate is a naturally occurring biodegradable and biocompatible polysaccharide recovered from seaweed such as brown algae. The main purpose of this study is to investigate the drug loading capacity of sodium alginate which extracted from waste seaweed. The sodium alginate is used to prepared beads with a different diameter of sizes for drug loading. The curcumin is an organic compound present in rhizomatous herbaceous perennial plant; commonly called turmeric, used for anticancer treatment and tumor cell reduction. Sodium alginate beads are prepared with 1% sodium alginate solution and cross-linked with zinc chloride solution. The sodium alginate beads are immersed in various concentrations of curcumin solutions to test the drug loading capacity. Further, equal proportions of sodium alginate and sodium carboxyl methyl cellulose blend solution is also used to prepare beads, followed by cross-linking with zinc chloride solution for drug loading investigation. The drug loading capacity of the sodium alginate beads are compared with sodium alginate and carboxyl methyl cellulose blend beads.