[1P-1128] SGMS2 gene is moderately down-regulated in the sphingomyelin-ceramide metabolic pathway in obesity

〇Eric Tzyy Jiann Chong¹, Yee Soon Ling², Ping-Chin Lee^1,2 (1.Biotechnology Programme, Fac. of Sci. and Natural Resources, Univ. Malaysia Sabah, UMS Road, 88400 Kota Kinabalu, Sabah, Malaysia, 2.Biotechnology Research Inst., Univ. Malaysia Sabah, UMS Road, 88400 Kota Kinabalu, Sabah, Malaysia)

ConBio2017

[1P-1129] Mitochondrial Dysfunction and Dysregulation of Ca2+ Homeostasis in Insulin Insensitivity and Diabetes

〇Yau-Huei Wei^1,2, Chih-Hao Wang³, Yu-Ting Wu^1,2, Ting-Fen Tsai³ (1.Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua, Taiwan 500, 2.Department of Medicine, Mackay Medical College, New Taipei City, Taiwan 252, 3.Department of Life Sciences and Institute of Genomic Sciences, National Yang-Ming University, Taipei, Taiwan 112)

ConBio2017

[1P-1130] COCCINIA GRANDIS ETHANOLIC EXTRACT ATTENUATES OBESITY INDUCED INFLAMMATION AND INSULIN RESISTANCE

〇Arisa Imsumran Bonness¹, Ploypailin Kaewprasert¹, Pornsiri Pitchakarn¹, Ariyaphong Wongnoppavich¹ (1.Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, THAILAND)

ConBio2017

[1P-1131] Selection of DNA aptamer that block the fibrillogenesis of a proteolytic amyloidogenic fragment of β2m (ΔN6β2m)

Kanon Fukasawa¹, 〇Yuichiro Higashimoto¹, Yukio Ando², Yoshihiro Motomiya³ (1.Dept. of Chem., Kurume Univ. Sch. of Med., 2.Dept. of Neurol., Grad. Sch. of Med. Sci., Kumamoto Univ., 3.Suiyukai Clinic)

ConBio2017

[1P-1132] The role of Dehydrogenase/reductase 2 (DHRS2), an MDM2 inhibitory factor, in induction of cellular senescence

〇Tsukasa Oda¹, Takayuki Sekimoto¹, Kiminori Kurashima¹, Ruri Nakamura², Miyako Matsuda², Masumi Ohata², Takayuki Yamashita¹ (1.Lab. of Mol. Genet., IMCR, Gunma Univ., 2.Grad. Sch. of Health & Sci., Gunma Univ.)

ConBio2017

[1P-1133] High-dose thiamine prevents brain lesions and prolongs survival of Slc19a3-deficient mice

〇Kenichiro Yamada¹, Kaoru Suzuki¹, Yayoi Fukuhara¹, Ai Tsuji², Katsumi Shibata², Nobuaki Wakamatsu¹ (1.Dept. Geneti., Inst for Develop. Res., Aichi Human Serv. Cetr. , 2.Dept of Nutr., Sch of Human Cultures, Univ. of Shiga Pref.)

ConBio2017

[1P-1134] Diabetic phenotype and complications of transgenic pigs introduced by dominant-negative mutant hepatocyte nuclear factor 1A (P291fsinsC)

〇Kazuhiro Umeyama^1,2, Masami Nakajima³, Kazuaki Nakano², Masahito Watanabe^1,2, Hitomi Matsunari^1,2, Takashi Yokoo⁴, Masaki Nagaya¹, Hiroshi Nagashima^1,2 (1.MUIIBR, Meiji Univ., 2.Dept. of Life Sci., Sch. of Agri., Meiji Univ., 3.Dept. of Ophthal., Nihon Univ. Sch. of Med., 4.Dept. of Intern. Med., Jikei Univ. Sch. of Med.)

ConBio2017

[1P-1135] The mechanism of cellular senescence induced by proteasome dysfunction

〇Tomohiro Iriki¹, Eiichi Hashimoto¹, Shoshiro Hirayama¹, Jun Hamazaki¹, Shigeo Murata¹ (1.Grad. Sch. of Pharm., Univ. of Tokyo)

ConBio2017

[1P-1136] clearance of senescent cells in the mouse postpartum uterus by F4/80+ macrophages and its influence on secondary pregnancy

〇Ryoko Shimizu-Hirota¹, Yasushi Hirota^2,3, Tomoko Saito-Fujita², Masahiro Egashira^2,4, Hirofumi Haraguchi², Takehiro Hiraoka², Shun Akaeda², Tomoki Tanaka², Tomoyuki Fujii², Yutaka Osuga² (1.Cent. of Prev. Med., Sch.of Med., Keio Univ., 2.Dept. of Obs. Gyne., Grad. Sch. of Med., Univ. of Tokyo, 3.PRESTO, Japan Science and Technology Agency, 4.Dept. of Vet. Med., Grad. Sch. of Agricul.and Life Sci., Univ.of Tokyo)

ConBio2017

[1P-1137] Control of cellular senescence by extracellular signals in exhaustive genome editing

〇Yoshiki Okita^1,2, Akira Watanabe¹, Akitsu Hotta¹, Shinji Masui¹ (1.CiRA, Kyoto Univ., 2.Dept. of Med. Sci., Grad. Sch. of Med., Univ. of Kyoto)

ConBio2017