[3PT26-11（3P-1464）] Long-term adaptation to a specific food condition may be sufficient to explain the major changes of life-history evolution.

〇Lucas S Trindade¹, Toshiro Aigaki², Kazutaka Akagi¹ (1.Aging Homeostasis Research Project Team, NCGG, 2.Dept. of Biol. Sci., Tokyo Metropolitan Univ.)

ConBio2017 |Fri. Dec 8, 2017 5:40 PM - 5:50 PM

[3PT26-12（3P-1066）] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity

〇Natsumi Sakata¹, Takahiro Horiuchi¹, Yoshihiro Narumi¹, Tomohiro Kimura¹, Takashi Hayashi², Keisuke Nagano², Keyue Liu³, Masahiro Nishibori³, Sohei Tsukita⁴, Yamada Tetsuya⁴, Hideki Katagiri⁴, Ryutaro Shirakawa¹, Hisanori Horiuchi¹ (1.Dept. of Molecular and Cellular Biology, IDAC, Tohoku Univ., 2.Otsuka Pharmaceutical Co., Ltd., 3.Dept. of Pharmacology, Grad. Sch. of Med, Dent, and Pharmaceutical Sci., Okayama Univ., 4.Dept. of Metabolism and Diabetes, Grad. Sch. of Med, Tohoku. Univ.)

ConBio2017 |Fri. Dec 8, 2017 5:50 PM - 6:00 PM

[3PT26-13（3P-1067）] Intestinal FXR mediates a systemic regulation of functional Beta cells to ameliorate type1 and type2 diabetes

〇Eiji Yoshihara^1,3, Sungsoon Fang^1,3, Chun Shi Lin¹, Ting Fu¹, Zong Wei¹, Jae Myoung Suh¹, Ruth Yu¹, Ann T. Atkins¹, Michael Downes¹, Ronald M. Evans^1,2 (1.Gene Expression Laboratory, Salk Institute, 2.Howard Hughes Medical Institute, 3.Equally contribution)

ConBio2017 |Fri. Dec 8, 2017 6:00 PM - 6:10 PM

[3PT26-14（3P-1068）] Molecular mechanisms by which FGF19 improves NASH

〇Mei Tsuchida¹, Mayuka Yamada¹, Miki Takahashi¹, Yusuke Hirata¹, Masaaki Miyata², Kouichi Yoshinari^1,3, Takuya Noguchi¹, Atsushi Matsuzawa¹ (1.Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 2.Dept. of Food Sci. Tech., National Fisheries Univ., 3.Grad. Sch. of Pharmaceut. Sci., Univ. of Shizuoka)

ConBio2017 |Fri. Dec 8, 2017 6:10 PM - 6:20 PM

[3PT26-15（3P-1069）] Regnase-1 maintains iron homeostasis via the destabilization of iron-regulatory transcripts

〇Masanori Yoshinaga¹, Takashi Mino¹, Osamu Takeuchi¹ (1.inFront, Kyoto Univ.)

ConBio2017 |Fri. Dec 8, 2017 6:20 PM - 6:30 PM

[3PW02-Introduction] Introduction

〇Shinichiro Nakada¹ (1.Osaka University)

ConBio2017 |Fri. Dec 8, 2017 4:00 PM - 4:05 PM

[3PW02-1] Molecular pathogenesis underlying Cockayne syndrome and UV-sensitive syndrome

〇Nan Jia¹, Chaowan Guo¹, Yasuyoshi Oka¹, Yuka Nakazawa^1,2, Mayuko Shimada², Hitomi Miyazaki², Tomoo Ogi^1,2 (1.Dept. of Genetics, RIeM, Nagoya Univ., 2.Dept. of Gen. Repair, Atom.Bomb Dise. Inst., Nagasaki Univ.)

ConBio2017 |Fri. Dec 8, 2017 4:05 PM - 4:28 PM

[3PW02-2] RNF168 mediates the recruitment of SLX4 via ubiquitination pathway during ICL repair

〇Yoko Katsuki¹, Masako Abe¹, Haico van Attikum², Shinichiro Nakada³, Masato Kanemaki⁴, Yonghwan Kim⁵, Minoru Takata¹ (1.Late Effects, Radiat. Biol. Center, Kyoto Univ., 2.Med. Center, Leiden Univ., 3.Dept. of Bioreg.& Cell. Resp., Grad. Sch. of Med., Osaka Univ., 4.Div. of Mol. Cell Eng., Nat. Inst. of Genet., 5.Genome Maint., Sookmyung Women's Univ.)

ConBio2017 |Fri. Dec 8, 2017 4:28 PM - 4:51 PM

[3PW02-3] Distinctly different contributions of two PAR-binding proteins, XRCC1 and ALC1 in PARP dependent genome maintenance.

〇Kouji Hirota¹, Masataka Tsuda², Masato Ooka¹, Naoto Shimizu², Akira Yasui³, Shunichi Takeda² (1.Department of Chemistry, Tokyo Metropolitan University, 2.Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 3.Division of Dynamic Proteome, Institute of Development, Aging and Cancer, Tohoku University)

ConBio2017 |Fri. Dec 8, 2017 4:51 PM - 5:14 PM

[3PW02-4] Simultaneous Single Nicking of Target Gene and Donor Plasmid Enables Safe and Efficient Gene Correction by Non-Canonical HDR.

Kazuhiro Nakajima¹, Yue Zhou¹, Akiko Tomita¹, Yoshihiro Hirade¹, 〇Shinichiro Nakada^1,2 (1.Cell. Resp. Grad Sch. Med. Osaka Univ., 2.Inst, Co-Cre. Osaka Univ.)

ConBio2017 |Fri. Dec 8, 2017 5:14 PM - 5:37 PM