[1P-394（2T16a-04）] Different mitochondrial DNA heteroplasmy distributions at the single-cell level in patients with mitochondrial diseases

Atsuko Okazaki¹, Kazuhiro R. Nitta^1,2, Yukiko Yatsuka¹, ^〇Ayumu Sugiura¹, Masato Arao³, Masaru Shimura⁴, Tomohiro Ebihara⁴, Takanori Onuki⁴, Keiko Ichimoto⁴, Akira Ohtake^3,5,6, Kei Murayama⁴, Yasushi Okazaki^1,2 (1. Diagnostics and Therapeutics of Intractable Diseases, Juntendo University, Graduate School of Medicine, 2.Laboratory for Comprehensive Genomic Analysis, Center for Integrative Medical Sciences, RIKEN, 3.Department of Pediatrics, Saitama Medical University, 4.Department of Metabolism, Chiba Children's Hospital, 5.Center for Intractable Diseases, Saitama Medical University Hospital, 6.Department of Clinical Genomics, Saitama Medical University)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-333（2T16a-05）] Molecular mechanisms of peliosis hepatitis associated with X-linked myotubular myopathy (XLMTM)

^〇Nobuyuki Shimizu¹, Hiroshi Shiraishi¹, Masanori Inoue², Kyoko Kiyota², Kenji Ihara², Toshikatsu Hanada¹ (1.Oita University Faculty of Medicine, Department of Cell Biology, 2.Oita University Faculty of Medicine, Department of Pediatrics)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-334] Pathogenic mechanisms and cellular response of GARRE mutation

^〇Yukinao Shibukawa¹, Natsuko Yamazaki¹, Nobuhiko Okamoto^1,2 (1.Department of Molecular Medicine, Research institute, Osaka Women's and Children's Hospital, 2.Department of Medical Genetic, Osaka Women's and Children's Hospital)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-335] Novel variants of ADAMTS3 causing Hennekam lymphangiectasia-lymphoedema syndrome and their expression analysis

Arisa Igarashi¹, Yoshio Makita², Kumiko Yanagi¹, Nana Kobayashi¹, Yukimi Abe¹, Tomomi Hidai¹, Makiko Omata¹, Kazuhito Satou¹, ^〇Tadashi Kaname¹ (1.Dept. of Genome Med., NCCHD, 2.Education center, Asahikawa Med Univ.)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-336] Role of senescent alveolar epithelial cells in pulmonary fibrosis

^〇Yasuhiro Takenouchi¹, Keisuke Kitakaze¹, Rie Sugimoto¹, Hironobu Ishimaru¹, Kazuhito Tsuboi¹, Yasuo Okamoto¹ (Dept. Pharmacol., Kawasaki Med. Sch.)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-337] Physiological role of IBD susceptibility gene LRRK2 in DSS-induced colitis.

^〇Fumitaka Kawakami^1,2, Ishikawa Yuta^1,2, Shun Tamaki^1,2, Rei Kawashima^1,2, Tatsunori Maekawa^1,2, Kenichi Ohba³ , Takafumi Ichikawa^1,2 (1.Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, 2.Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, 3.Department of Health Administration, School of Allied Health Sciences, Kitasato University)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-338（3T15a-02）] Omega-6 unsaturated fatty acid-containing phospholipids control acute liver failure.

^〇Natsuko F. Inagaki^1,2, Hiroki Nakanishi³, Takayo Ohto³, Hideo Shindou^2,4, Takao Shimizu^2,5 (1.Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 2.National Center of Global Health and Medicine, 3.Lipidome Lab Co., Ltd., 4.Faculty of Medicine, The University of Tokyo , 5.Institute of Microbial Chemistry)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-339（3T15a-06）] HIF-2 is associated with pulmonary neuroendocrine cell hyperplasia in a mouse of asthma.

^〇Kento Takahashi¹, Erina Ike¹, Tasuku Kawano¹, Tomoko Takahashi¹ (Division of Pathophysiology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-340（3T15a-07）] The analysis of epigenetic regulation in retinal ischemic diseases.

^〇Takuma Neo^1,2, Kengo Nakanishi¹, Yoshihiro Takamura³, Masaru Inatani³, Masaya Oki^1,4 (1.Dept. of Appl. Chem. Biotech., Grad. Sch. of Eng., Univ. of Fukui, 2.Research fellow, JSPS, 3.Dept. of Opthalmol., Fac. of Med. Sci., Univ. of Fukui, 4.Life Science innovation center, Univ. of Fukui)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-341（3T15a-03）] Decrease of Adra1a expression enhances cardiac hypertrophy in pregnancy-associated hypertensive mice.

^〇Shin-ichi Muroi^1,3, Jun-Dal Kim^1,3, Akiyoshi Fukamizu^2,3, Yoshimi Nakagawa¹ (1.Division of Complex Bioscience Research, Institute of National Medicine, University of Toyama, 2.Life science center for survival dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, 3.AMED-CREST, Japan Agency for Medical Research and Development)

The 95th Annual Meeting of the Japanese Biochemical Society