[1P-296] Systemic niacin metabolism that limits efficacy of NAD-targeted therapy in cancer

^〇Miyuki Nomura¹, Mai Oh-uchi¹, Shigemi Ito¹, Mami Morita¹, Naohiko Kikuchi¹, Taku Sato¹, Takashi Nakagawa², Nobuhiro Tanuma^1,3 (1.Miyagi Cancer Center Res Inst, 2.Dept Mol Med Pharm, Fucl Med, Univ Toyama, 3.Dept Biochem Oncol, Tohoku Univ Grad Sch Med)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-297] NAD biogenesis is a targetable vulnerability of small-cell lung and prostate cancers

Oh-uchi Mai¹, shuko Miyahara^1,2, Miyuki Nomura¹, Yoshimi Sakamoto¹, Shigemi Ito¹, Mami Morita¹, Taku Sato¹, Naohiko Kikuchi¹, ^〇Nobuhiro Tanuma^1,2 (1.Miyagi Cancer Center Res Inst, 2.Dept Biochem Oncol, Tohoku Univ Grad Sch Med)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-298] Roles of aldo-keto reductase 1C3, MAP kinase and Akt in development of cisplatin resistance in breast cancer cells in the presence of estrogen

Yukino Nagao¹, Yuji Sakai², Yoshifumi Morikawa², Aki Hisamatsu³, Kazuhiro Iguchi⁴, ^〇Toshiyuki Matsunaga^1,3 (1.Laboratory of Bioinformatics, Gifu Pharmaceutical University, 2.Forensic Science Laboratory, Gifu Prefectural Police Headquarters, 3.Education Center of Green Pharmaceutical Sciences, Gifu Pharmaceutical University, 4.Laboratory of Community Pharmacy, Gifu Pharmaceutical University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-299] v-Src induces multipolar spindle formation via inhibition of the Hippo pathway

^〇Yuji Nakayama¹, Ryoko Ota¹, Hiroki Kuwajima¹, Ryuji Yasutake¹, Ryuzaburo Yuki¹, Youhei Saito¹ (Kyoto Pharmaceutical University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-300] Mechanism of Epithelial Maintenance by PKC in Colorectal Cancer Cells

^〇Chiaki Yamada¹, Noi Ikeo¹, Ota Sae ¹, Satow Reiko¹, Kiyoko Fukami¹ (Tokyo University of Pharmacy and Life Sciences)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-301（1T16a-06）] Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma

^〇Jianbo An¹, Yushi Nagaki², Midori Hoshizaki^1,3, Tomokazu Yamaguchi¹, Yuta Kuze⁴, Yumiko Imai³, Satoru Motoyama², Yutaka Suzuki⁴, Keiji Kuba¹ (1.Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 2.Department of Comprehensive Cancer Control, Akita University Graduate School of Medicine, 3.National Institute of Biomedical Innovation, Health and Nutrition, 4.Laboratory of Systems Genomics, Department of Computational Biology and Medi cal Sciences, Graduate School of Frontier Sciences, The University of Tokyo)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-302（2T14a-02）] Development of a novel peptide-based therapeutic compound against CML by targeting the PH domain of p210 BCR-ABL

^〇Aoi Ikegami¹, Miho Takahashi¹, Masaya Tyoda¹, Kentaro Shimasaki², Norihito Shibata³, Mikihiko Naito⁴, Kiyotaka Nishikawa¹ (1.Molecular Life Sciences Laboratory, Faculty of Life and Medical Sciences, Doshisha University, 2.Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 3.Division of Biochemistry Section2, National Institute of Health Sciences, 4.Laboratory of Targeted Protein Degradation, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-303（2T14a-08）] The Neurofibromatosis type 2 gene NF2 (Merlin)-mediated regulation of xCT/SLC7A11 expression controls glucose dependency of glioblastoma cells

^〇Itsuki Yamaguchi¹, Hironor Katoh¹ (Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-304（1T15a-06）] The functional analysis of transcription factor GATA1 in erythroleukemia

^〇Shiho Narusawa¹, Ikuo Hirano^1,2, Jia Yao¹, Tsz Ki Yip¹, Aya Ashizawa¹, Ritsuko Shimizu^1,2 (1.Department of Molecular Hematology, Tohoku University Graduate School of Medicine, 2.Tohoku Medical Megabank Organization, Tohoku University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-305（1T15a-07）] Molecular mechanisms of selective poly(ADP-ribose)glycohydrolase inhibitor PDD00017273 resistance in human colorectal cancer HCT116 cells.

^〇Kaede Tsuda¹, Chinatu Kurasaka¹, Yoko Ogino^1,2, Akira Sato¹ (1.Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science., 2.Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science.)

The 95th Annual Meeting of the Japanese Biochemical Society