[1P-096（1T07a-05）] Facilitating the CFTR deubiquitination at the plasma membrane enhances the efficacy of CF therapeutic agents

^〇Yuto Kobayashi¹, Yoshiaki Morishima¹, Naoki Tsuji¹, Ryosuke Fukuda¹, Daisuke Oikawa², Fuminori Tokunaga², Tsukasa Okiyoneda¹ (1.Department of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, 2.Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-097（1T07a-06）] UBC13 promotes chemically-induced degradation of cIAP1 through branched ubiquitin chains

^〇Yoshino Akizuki^1,2, Fumiaki Ohtake^1,2 (1.Graduate School of Pharmaceutical Sciences, Hoshi University, 2.Institute for Advanced Life Sciences, Hoshi University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-098（1T07a-07）] Dynamic structural change model of bacterial intramembrane protease RseP during substrate accommodation and cleavage

^〇Takuya Miyake¹, Yuki Imaizumi², Kazunori Takanuki², Tatsuya Kobayashi¹, Tatsuhiko Yokoyama¹, Rika Oi², Yohei Hizukuri¹, Terukazu Nogi², Yoshinori Akiyama¹ (1.Institute for Life and Medical Sciences, Kyoto University, 2.Graduate School of Medical Life Science, Yokohama City University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-099（1T07a-08）] Humoral factor induced by TBK1 facilitates elimination of abnormal monomeric TDP-43.

^〇Shohei Sakai¹, Kotaro Oiwa^1,2, Seiji Watanabe¹, Okiru Komine¹, Koji Yamanaka¹ (1.Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, 2.Department of Neurology, Nagoya University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-100] Genome-wide CRISPR/Cas9 screening for factors regulating the degradation of misfolded membrane proteins at the ER

^〇Satoshi Hayakawa¹, Yuki Hayashi¹, Hidenori Ichijo¹ (Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-101（1T07a-09）] The analysis of the novel extracellular chaperones that degrade the extracellular aberrant proteins

^〇Momoka Chiba¹, Eisuke Itakura², Akira Matsuura² (1.Department of Biology, Graduate school of Science and Engineering, Chiba University, 2.Department of Biology, Graduate school of Science, Chiba University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-102（2T06a-01）] Quality control of Nuclear Pore Complexes(NPCs) during heat stress by ubiquitin-proteasome systems

^〇Shota Shimizu¹, Rina Hattori² (1.Shizuoka University, Graduate School of Integrated Science and Technology, Department of Agriculture, 2.Shizuoka University, Faculty of Agriculture)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-103] Analysis of the regulatory mechanism for endocytosis of extracellular proteins

^〇Mako Kiyota¹, Akira Matsuura², Eisuke Itakura² (1.Department of Biology, Graduate school of Science and Engineering, Chiba University, 2.Department of Biology, Graduate school of Science, Chiba University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-104（2T06a-02）] Construction and analysis of cell lines expressing proximity-dependent biotinylation enzyme (AirID)-fused DCAF family proteins

^〇Koya Nagaoka¹, Masahiro Kawano¹, Yuki Syoya¹, Satoshi Yamanaka², Kohei Nishino³, Hidetaka Kosako³, Tatsuya Sawasaki¹ (1.Div. Cell-Free Sci., PROS, Ehime Univ., 2.Div.Proteo-Interactome, PROS, Ehime Univ., 3.Fujii Memorial Inst. of Med. Sci., Inst. of Adv. Med. Sci., Tokushima Univ.)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-105] Generation of synthetic binding proteins against the ligand-binding region of low-density lipoprotein receptor

^〇Norihisa Yasui^1,2, Yusuke Nakamura², Atsuko Yamashita^1,2 (1.Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2.Faculty of Pharmaceutical Sciences, Okayama University)

The 95th Annual Meeting of the Japanese Biochemical Society