[1P-034(1T02a-07)] Elucidation of the physiological functions of GnT-III in neuron

^〇Yuta Hashimoto¹, Shun Yamaguchi², Yoshiki Yamaguchi³, Yasuhiko Kizuka^1,4 (1.Graduate School of Natural Science and Technology, Gifu University, 2.Graduate School of Medicine, Gifu University, 3.Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4.Institute for Glyco-core Research (iGCORE), Gifu University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-035] Functional analysis of novel mutation and variants in the SPG26 causative gene B4GALNT1

^〇Kei-ichiro Inamori¹, Fumi Shishido², Jia-Chen Hsu¹, Masakazu Nagafuku¹, Takahiro Nitta³, Katsuya Nakamura^4,5, Naomi Tsuchida⁶, Junji Ikeda⁴, Minori Kodaira⁴, Akira Togayachi⁷, Jun-ichi Furukawa⁸, Yoshiki Yamaguchi⁹, Kiyoko F Aoki-Kinoshita⁷, Tadashi Kaname¹⁰, Yutaka Nakamura², Isao Ohno², Masahiko Nakamura¹¹, Takayoshi Shimohata¹², Naomichi Matsumoto⁶, Tomoki Kosho ^5,13, Yoshiki Sekijima⁴, Kengo Kinoshita¹⁴, Shoko Nishihara⁷, Jin-ichi Inokuchi¹⁵ (1.Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 2.Center for Medical Education, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 3.Institute for Environmental and Gender-Specific Medicine, Graduate School of Medicine, Juntendo University, 4.Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, 5.Center for Medical Genetics, Shinshu University Hospital, 6.Department of Human Genetics, Yokohama City University Graduate School of Medicine, 7.Glycan and Life System Integration Center (GaLSIC), Soka University, 8.Institute for Glyco-core Research (iGCORE), Nagoya University, 9.Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 10.Department of Genome Medicine, National Center for Child Health and Development, 11.Department of neurosurgery, Matsumoto City Hospital, 12.Department of Neurology, Gifu University Graduate School of Medicine, 13.Department of Medical Genetics, Shinshu University School of Medicine, 14.Tohoku Medical Megabank Organization, Tohoku University, 15.Forefront Research Center, Graduate School of Science, Osaka University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-036] Expression of fucosyltransferase 8 (FUT8) and core fucose in antioxidative stress response

^〇Ayano Satoh¹, Yuki M. Kyunai¹ (Okayama University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-037] Enzyme replacement for galactosialidosis model mice with recombinant human CTSA derived from TG-silkworm cocoon and N-glycan modified-proCTSA

^〇Teru Mizuno¹, Yoshie Takeuchi², Yuto Horii¹, Jun Tsukimoto¹, Michiko Kino³, Naozumi Ishimaru³, Yasuo Shinohara^1,2,4, Kohji Itoh^1,2,5 (1.Graduate School of Pharmaceutical Sciences, Tokushima University, 2.Faculty of Pharmacy, Tokushima University, 3.Graduate School of Oral Sciences, Tokushima University, 4.Institute of Advanced Medical Sciences, Tokushima University, 5.Jichi Medical University School of Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-038(1T03a-10)] Discovery and enzymatic properties of a novel deaminoneuraminic acid (Kdn)-specific aldolase from Sphingobacterium sp.

^〇Takahiro Nakagawa^1,2, Yuya Iwaki^1,2, Di Wu^1,2,3, Masaya Hane^1,2,3, Chihiro Sato^1,2,3, Ken Kitajima^1,2,3 (1.Biosci. Biotech. Center, Nagoya Univ., 2.Grad. Sch. Bioagr. Sci., Nagoya Univ., 3.iGCORE, Nagoya Univ)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-039] Analysis of NFE2L1(NRF1) maturation mechanism by cytosolic peptide : N-glycanase

^〇Yuriko Tachida¹, Hiroto Hirayama¹, Tadashi Suzuki¹ (Glycometabolic Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Takeda-CiRA Joint Program (T-CiRA))

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-040] Easy and high sensitive system for the detection of NGLY1 activity

^〇Haruhiko Fujihira^1,2, Keiko Sato¹, Yuji Nishiuchi³, Takefumi Murase³, Yuka Matsuda³, Takayuki Kamei⁴, Tadashi Suzuki^1,5 (1.Glycometabolic Biochem Lab, CPR, RIKEN, 2.Division of Glycobiologics, Juntendo Univ Grad School of Med, 3.GlyTech, Inc, 4.Global Advanced Platform, Takeda Pharmaceutical Co Ltd, 5.Suzuki Project, T-CiRA Joint Program)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-041] Substitution of the hydrophobic amino acid residues affects the dimerization required for the enzymatic activity of human α1,6-fucosyltransferase (FUT8)

^〇Hideyuki Ihara¹, Takahiro Okada¹, Naoyuki Taniguchi², Yoshitaka Ikeda¹ (1.Div. Mol. Cell Biol., Dept. Biomol. Sci., Saga Univ. Fac. Med., 2.Dept. Glyco-Oncology and Medical Biochemistry, Osaka International Cancer Institute)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-042] Analysis of novel O-glycoprotease from Elizabethkingia miricola

^〇Shou Takashima¹, Masaki Kurogochi², Kazuko Hachisu², Mamoru Mizuno², Yoshio Takada¹ (1.Lab. of Glycobiology, The Noguchi Inst., 2.Lab. of Glyco-Organic Chemistry, The Noguchi Inst.)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-043] Attempt to establish Histo-blood group antigen expressing cells for Human Norovirus infection

^〇Maro Shibata^1,2, Yuta Homma¹, Suzuki Yusuke², Kousuke Murakami³, Yuichi Someya³, Toshiyuki Yamaji¹ (1.Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 2.Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 3. Department of Virology II, National Institute of Infectious Diseases)

The 96th Annual Meeting of the Japanese Biochemical Society