The 96th Annual Meeting of the Japanese Biochemical Society

Oct 31, 2023 - Nov 2, 2023
Fukuoka International Congress Center MARINE MESSE FUKUOKA Hall B

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2324 results (2281 - 2290)

[1P-675] The anti-TLR4 monoclonal antibody Sa15-21 enhances inflammatory cytokine production in LPS-stimulated macrophages

^〇MASANORI INUI¹, TATSUYA YAMAZAKI¹, SUSUMU TOMONO¹, HIDEKAZU TAKAGI¹, SACHIKO TAKAMURA¹ (Department of Microbiology and Immunology, Aichi Medical University School of Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-676] ApoE receptor-mediated uptake of pyrrolated proteins by macrophages

^〇Mao Okamoto¹, Masanori Itakura¹, Koji Uchida¹ (Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences, The University of Tokyo.)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-677] A novel system to detect Aβ fibril extension and dissociation at nM range of Aβ monomer, close to the physiological concentration in the brain.

^〇Kazuhiro Hasegawa¹, Hironobu Naiki¹ (Dept of Pathological Sci, Univ of Fukui)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-678] Molecular interaction and mechanism of UBL3 and α-Synuclein

Jing Yan¹, Hengsen Zhang¹, Bin Chen¹, Yashuang Ping¹, Md. Shoriful Islam¹, Yuna Tomochika¹, Shuhei Aramaki¹, Tomohito Sato¹, Yu Nagashima¹, Tomohiko Nakamura¹, ^〇Tomoaki Kahyo¹, Mitsutoshi Setou¹, (Hamamatsu University School of Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-679] FaiGT: Fragment artificial intelligence-Generative Transformer

^〇Kazutoshi Kiyooka¹, Takuma Shiraki² (¹Graduate School of Biology-Oriented Science and Technology Major in Biotechnological Science, ²Faculty of Biology-Oriented Science and Technology Department of Science and Technology on Food Safety)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-680] Development of IFNα formulation to induce cancer immune regulator CD169 in lymph nodes.

^〇Ryo Fukuda¹, Yukio Fujiwara², Hitoshi Maeda¹, Hiroshi Watanabe¹, Yoshihiro Komohara², Toru Maruyama¹ (¹Department of Pharmacy, Kumamoto University, ²Department of Cellpathology, Kumamoto University School of Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-681] Development of IL13RA2-retargeted syncytial oncolytic herpes simplex virus (IL13RA2-specific RRsyn-oHSV)

^〇Takuma Suzuki¹, Hideaki Tahara², Hiroaki Uchida¹ (¹Tokyo University of Pharmacy and Life Sciences, ²Osaka International Cancer Institute)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-652] Functional analysis of DGKθ in fibroblast cell proliferation

^〇Shuji Ueda¹, Xiaoya Li¹, Emi Inoue¹, Kazuki Ito ¹, Mako Yamaguchi¹, Nao Koizumi¹, Itsuko Fukuda¹, Yasuhito Shirai¹, (Kobe University Agricultual Sciecne)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-653] Photo-control of Mitotic Kinesin Eg5 using Photoresponsive Protein (Aureochrome1 and Dronpa 145N).Department of Biosciences, Graduate School of Science and Engineering, Soka University, Hachioji, Tokyo, Japan.Soka university, Faculty of Science and Engineering, Department of science and Engineering for Sustainable Innovation.Besong Stanley Tabi, Islam MD Alrazi, Nobuyuki Nishibe and Shinsaku MarutaMitotic Kinesin Eg5 is a member of kinesin superfamily that is essential for Mitosis. Kinesin Eg5 is a motor protein that is homotetramer in structure which help during cross-links of anti-parallel microtubules in the mitotic spindle to maintain spindle bipolarity. Previously we have incorporated photochromic compounds of azobenzene derivatives into the functional site of Eg5 and controlled the Eg5 ATPase activity photoreversible. Aueochrome1 and Dronpa are photo responsive proteins and considered as a photochromic molecular device. It is known that the variants of aureochrome1, photozipper (PZ) and variant of Dronpa, Dronpa145N exhibit monomer-dimer conversion photoreversibly. In this study we tried to control the activity of kinesin Eg5 by introducing the variants of the photochromic protein into C-terminal of Eg5 motor domain. The designed fusion proteins of Eg5-PZ and Eg5-Dronpa145N were successfully expressed by E. coli expression system. Eg5-PZ showed spectral changes upon blue light irradiation and in the dark indicating photoisomerization. Monomer-dimer conversion of Eg5-PZ accompanied by photoisomerization was also observed by using size exclusion chromatography. However, ATPase activity of Eg5-PZ was not changed by blue light irradiation and in the dark. On the other hand, Eg5-Dronpa145N did not show spectral change upon 400 nm and 500 nm alternate light irradiations indicating that Eg5-Dronpa145N does not exhibit photoisomerization.

^〇STANLEY TABI BESONG ¹, Islam MD Alrazi¹, Nobuyuki Nishibe¹, Shinsaku Maruta¹ (Soka university Japan )

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-654] Comparison of the iron core between Escherichia coli ferritin and Chlorobaculum tepidum ferritin

^〇Haruki Sakakibara¹, Takumi Kuwata¹, Kazuo Fujiwara¹, Masamichi Ikeguchi¹ (Department of Biosciences, Graduate School of Science and Engineering, Soka University)

The 96th Annual Meeting of the Japanese Biochemical Society

2324 results (2281 - 2290)