[1T10a-02(1P-299)] Autophagy independent function of ATG-18/WIPI in longevity

^〇Ittetsu Takahashi¹, Tatsuya Shioda¹, Harunori Yoshikawa², Tatsuya Kaminishi^3,4, Hidetaka Kosako², Tamotsu Yoshimori^1,3,4, Shuhei Nakamura⁵ (1.Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, 2.Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima University, 3.Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan, 4.Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 5.Department of Biochemistry, Nara Medical University, Nara, Japan)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 1:49 PM - 1:58 PM

[1T10a-03(1P-296)] A simple and rapid method for evaluation of autophagic flux in vivo.

^〇Yuki Kanda¹, Tomoya Eguchi¹, Hideaki Morishita¹, Yutaro Hama¹, Manabu Abe², Kenji Sakimura², Noboru Mizushima¹ (1.Dept. of Biochemistry and Molecular Biology, Graduate School, and Faculty of Medicine, The University of Tokyo, 2.Dept. of Animal Model Development, Brain Research Institute, Niigata University)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 1:58 PM - 2:07 PM

[1T10a-04(1P-300)] Ferropotosis-mediated lysosomal dysfunction and defense mechanisms in glucose starved condition

^〇Kenji Miki^1,2, Mikako Yagi^1,3, Dongchon Kang^1,4, Yuya Kunisaki¹, Koji Yoshimoto², Takeshi Uchiumi^1,3 (1.Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 2.Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3.Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 4.Kashiigaoka rehabilitation hospital)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:07 PM - 2:16 PM

[1T10a-05(2P-298)] Autophagy inducer screening mediated by Lysosomal clustering and the degradation analysis of α-Synuclein aggregation

^〇Yuki Date^1,2, yukiko sasazawa^2,3,4, Mitsuhiro Kitagawa^2,3, Hideyuki Saya⁵, Masaya Imoto³, Eisuke Itakura⁶, Shinji Saiki^7,8, Nobutaka Hattori^7,9 (1.Department of Biology, Graduate school of Science and Engineering, Chiba University, 2.Department of Neurology, Juntendo University School of Medicine, 3.Juntendo University School of Medicine Juntendo University Graduate School of Medicine, 4.Research Institute for Diseases of Old Age, 5.Fujita medical university, cancer centar, 6.Department of Biology, Graduate school of Science, Chiba University, 7.Department of Neurology, Juntendo University School of Medicine, 8.Department of Neurology, Tsukuba University School of Medicine, 9.Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Japan)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:16 PM - 2:25 PM

[1T10a-06(1P-306)] Elucidation of the molecular mechanism of the tumor-suppressive cell competition through the induction of a "kick-me-out" signal, FGF21

^〇Motoyuki Ogawa¹, Mina Yano¹, Isao Naguro¹, Hidenori Ichijo¹ (Cell Signaling, Grad. Sch. Pharmaceut. Sci., Univ. of Tokyo)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:25 PM - 2:34 PM

[1T10a-07(1P-309)] A novel mechanism of ferroptosis execution mediated by Piezo1/TRP mechanosensitive channels

^〇Yusuke Hirata¹, Yoshiro Saito², Spencer Freeman³, Sergio Grinstein³, Atsushi Matsuzawa¹ (1.Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 2.Lab. of Mol. Biol. Metab., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 3.Program in Cell Biology, The Hospital for Sick Children, Toronto, Canada)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:34 PM - 2:43 PM

[1T10a-08(2P-315)] Generation and phenotypic analysis of GPx4 amino acid mutant mice (human metaphyseal dysplasia model)

^〇Isaku Tanabe¹, Mayu Ota¹, Shu Nakajima¹, Hirotaka Imai¹ (Grad.Sch.Pharm.Sci, Kitasato Univ)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:43 PM - 2:52 PM

[1T10a-09(1P-325)] Importance of lysosomal exocytosis in adaptation of cancer cells to acidic environment and its regulatory mechanism

^〇Yosuke Funato¹, Hiroaki Miki¹ (Department of Synthetic Chemistry and Biologcal Chemistry, Kyoto University Graduate School of Engineering)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:52 PM - 3:01 PM

[1T10a-10(1P-317)] The ER stress IRE1-XBP1 pathway maintains youthful skin through the regulation of epidermal stem cell proliferation

^〇Daniel Semmy¹, Kota Abe¹, Mizuki Honda², Shinya Oki², Yasuyuki Ohkawa³, Tohru Ishitani¹ (1.Dept. of Homeostatic Regulation, Research Institute of Microbial Diseases, Osaka University, 2.Dept. of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University, 3.Div. of Transcriptomics, Medical Institute of Bioregulation, Kyushu University)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 3:01 PM - 3:10 PM

[1T10a-11(2P-319)] A role of ES1, a novel dicarbonyl-metabolic enzyme, in mitochondrial glycation stress

^〇Ginga Ito¹, Minami Saito¹, Nanami Furukawa¹, Yota Tatara², Ken Itoh², Taku Ozaki¹ (1.Laboratory of Cell Biochemistry, Faculty of Science and Engineering, Iwate University, 2.Laboratory of Stress Response Science, Graduate School of Medicine, Hirosaki University)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 3:10 PM - 3:19 PM