[1P-624] Development of High-throughput screening technology for Aggregation Inhibitors of Diseased cell-derived Aggregative Proteins (HaiDap) system

^〇Masahiro Kuragano¹, Naoki Nishishita², Akira Kobayashi², Taro Q.P. Noguchi³, Kenichi Watanabe⁴, Shinya Watanabe¹, Stefan Baar¹, Koji Uwai¹, Kiyotaka Tokuraku¹ (1.Graduate School of Engineering, Muroran Institute of Technology, 2.Regenerative Medicine and Cell Therapy Laboratories, KANEKA CORPORATION, 3.Department of Chemical Science and Engineering, National Institute of Technology, Miyakonojo College, 4.Department of Veterinary Medicine, Research Center of Global Aeromedicine, Obihiro University of Agriculture and Veterinary Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-625] Endogenous brain peptide p3-Alcβ inhibits the effect of Ca²⁺ influx into neurons by Aβ oligomers

^〇Koichi Moteki¹, Haruka Saito¹, Shoichi Kinoshita¹, Saori Hata^1,2, Toshiharu Suzuki¹ (1.Graduate School of Pharmaceutical Sciences, Hokkaido University, 2.Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-626] Prevention of neurodegenerative diseases by novel vaccines based on the three-dimensional structure of abnormal protein aggregates

^〇Takashi Nonaka¹, Reiko Ohtani¹, Masato Hasegawa¹ (Dementia Project, Tokyo Metropolitan Institute of Medical Science)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-627(1T15a-12)] Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges.

^〇Tamami Miyagi¹, Rio Yamazaki¹, Kohsuke Kanekura¹ (Dept. pharmacology, Tokyo medical university)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-628] Polydipsia in saposin-D deficient mice results from increased prosaposin in subfornical organ.

^〇Harumi Hisaki¹, Takao Susa¹, Noriyuki Okudaira¹, Miho Akimoto¹, Shunya Uchida², Mimi Adachi-Tamamori¹ (1.Dept.of Biochemistry Teikyo Univ. Sch of Med, 2.Teikyo Heisei University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-629] LRRK2-mediated phosphorylation and secondary structure of Rab12 are regulated by bound nucleotides

^〇Genta Ito¹, Taisuke Tomita^2,3, Naoko Utsunomiya-Tate¹ (1.Department of Biomolecular Chemistry, Faculty of Pharma-Sciences, Teikyo University, 2.Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3.Social Cooperation Program of Brain and Neurological Disorders, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-630(1T18a-05)] Identification of SREBP-1 binders by high-throughput screening

^〇Kahori Hiro¹, Yu Takahashi¹, Takashi Maruyama¹, Takayoshi Okabe², Hirotatsu Kojima², Yoshio Yamauchi¹, Ryuichiro Sato¹ (1.Graduate School of Agricultural and Life Sciences, The University of Tokyo, 2.Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-631(1T18a-06)] Development of Novel SARS-CoV-2 Spike Binding Molecules using G-quadruplex based DNA Aptamer; IRDAptamer

^〇Masataka Mizunuma¹, Mirai Suzuki¹, Yuki Hara¹, Tamaki Kobayashi¹, Kazuhiro Furukawa², Yoshiro Chuman¹ (1.Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Niigata University, 2.Cell Regulation Laboratory in Biochemistry, Department of Chemistry, Faculty of Science, Niigata University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-632] Discovery of new E3 ligands for PROTAC design

^〇Reina Takano^1,2, Hidetomo Yokoo², Nobumichi Ohoka², Kenji Ogane³, Takao Inoue², Yosuke Demizu^1,2 (1.Grad. Sch. Med. Life Sci., Yokohama City Univ., 2. NIHS, 3.Sci., Ochanomizu Univ.)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-633] The nitroxide radical TEMPO prevents ferroptosis and neuronal cell death in an airborne manner

^〇Seiji Torii¹, Hiroyuki Mizuno^1,2, Chisato Kubota^1,3, Yuta Takigawa⁴, Ryosuke Shintoku^1,2, Yuhei Yoshimoto², Ichiro Koshiishi⁴ (1.Gunma University Center for Food Science and Wellness (GUCFW), 2.Gunma University Graduate School of Medicine, 3.Department of Nutrition, Takasaki University of Health and Welfare, 4.Gunma University Graduate School of Health Sciences)

The 96th Annual Meeting of the Japanese Biochemical Society