[3P-0255] Altered calcium dynamics of human neurons with TSC2 mutation

○Chihiro Hisatsune¹, Tadayuki Shimada¹, Akitoshi Miyamoto², Kanato Yamagata¹ (1.Synaptic Plasticity, TMiMS, 2.Lab. of Single-Mol. Cell Biol., Univ. of Kyoto)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0256] Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration

○Hitoshi Murata¹, Toshiki Ochi¹, Ken-ichi Yamamoto¹, Rie Kinoshita¹, Masakiyo Sakaguchi¹ (1.Dept. of Cell Biol., Grad. Sch. of Med. Dent. and Pharm., Univ. of Okayama)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0257] Disruption of Tsukushi function leads to the hydrocephalus by aberrant neurogenesis in the brain

○Kunimasa Ohta^1,2, Shah Adil Ishtiyaq², Mohammad Badrul Anam², Naofumi Ito² (1.Fac. of Arts & Sci., Kyushu Univ. , 2.Grad. Sch. of Life Sci., Kumamoto Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0258] Pharmacological activation of SERCA ameliorates dystrophic phenotypes and mitochondrial respiratory function in dystrophin-deficient mdx mice

○KENICHIRO NOGAMI^1,2, Yusuke Maruyama^1,3, Fusako Takemura¹, Norio Motohashi¹, Ahmed Elhussieny⁴, Michihiro Imamura¹, Satoshi Miyashita⁵, Megumu Ogawa⁶, Satoru Noguchi^6,7, Katsuya Miyake⁹, Yuki Tamura¹⁰, Jun-ichi Kira², Yoshitsugu Aoki¹, Shin'ichi Takeda⁸, Yuko Suzuki¹ (1.Dept. of Mol. Ther., Natl. Inst. of Neurosci., NCNP, 2.Dept. of Neurol., Grad. Sch. of Med. sci., Kyushu Univ., 3.Dept. of gen. reg., Grad. Sch. of Pharm. Sci., Tokyo Univ. of Sci., 4.Dept. of Neurol., Fac. of Med., Minia Univ., 5.Dept. of Biochem. and Cell. Biol., Natl. Inst. of Neurosci., NCNP, 6.Dept. of Neuromuscul. Res., Natl. Inst. of Neurosci., NCNP, 7.Dept. of Clin. Dev., Transl. Med. Ctr., NCNP, 8.NCNP, 9.Ctr. for Basic Med. Res., Int'l. Univ. of Health and Welfare , 10.Res. Inst. for Sport Sci., Nippon Sport Sci. Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0259] Glutamate-dependent reactivation of preexisting-GSK3β is involved in dendritic tau hyperphosphorylation.

○Toru Tanaka¹, Sachiyo Ohashi¹, Akihiko Takashima², Shunsuke Kobayashi¹ (1.Dept. of Biochem., Sch. of Pharm., Nihon Univ., 2.Dept. of Life Sci., Fac. of Sci., Gakushuin Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0260] Development of a novel Drosophila model for Charcot-Marie-Tooth disease by the knockdown of SCOX

○Ryosuke Kowada¹, Masamitsu Yamaguchi², Hideki Yoshida¹ (1.Dept. pf Appl. Biol., Kyoto inst. of Technol., 2.Kansai Gakken Lab., Kankyo Eisei Yakuhin Co. Ltd.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0261] Deficiency of MTH1 and/or OGG1 accumulates 8-oxoguanine in brain of App^NL-G-F knock-in mouse model of Alzheimerʼs disease, accompanied by acceralated microgliosis and anti-anxiety behavior

○Yuri Mizuno¹, Takashi Saito^2,3, Takaomi C Saido³, Yusaku Nakabeppu¹ (1.Div. Neurofunctional Genomics, Med. Inst. Bioreg., Kyushu Univ., 2.Dept. Neurocognitive Sci., Grad. Sch. Med. Sci., Nagoya City Univ., 3.Lab. Proteolytic Neuroscience, RIKEN Center for Brain Sci.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0262] Calcineurin-deficient glial cells in the small intestine have reduced proliferative capacity and altered levels of secreted substances in culture

○Hikaru Teramoto¹, Naohide Hirashima¹, Masahiko Tanaka¹ (1.Dept. of Cell. Biophys., Grad. Sch. of Pharmaceut. Sci., Nagoya City Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0263] Development of a novel Drosophila model for neurodevelopmental disorders targeting BCL11A/B

○Mizuki Yamaguchi¹, Akari Takai³, Tomohiro Chiyonobu³, Masamitsu Yamaguchi², Hideki Yoshida¹ (1.Dept. of Appl. Biol., Kyoto Inst. of Technol., 2.Kansai Gakken Lab.,Kankyo Eisei Yakuhin Co.Ltd., 3.Dept.of Pediatrics,Kyoto Prefectural Univ.of Medicine)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[3P-0264] Synaptic connection-dependent and independent propagation of α-synuclein in the C. elegans neural circuit.

○XUAN WANG^1,2, Yoichi Shinkai¹, Motomichi Doi^1,2 (1.Biomedical RI, AIST, Tsukuba, Ibaraki, JP, 2.Grad. Sch. of Life & Env. Sci., U. Tsukuba, Tsukuba, Ibaraki, JP)

The 43rd Annual Meeting of the Molecular Biology Society of Japan